Results 121 to 130 of about 96,425 (243)

Antiproliferative and Proapoptotic Activity of Sunitinib on Endothelial and Anaplastic Thyroid Cancer Cells via Inhibition of Akt and ERK1/2 Phosphorylation and by Down-Regulation of Cyclin-D1 [PDF]

, 2013
Teresa Di Desidero, Anna Fioravanti, Paola Orlandi, Bastianina Canu, Riccardo Giannini, Nicla Borrelli, Shan Man, Ping Xu, Gabriella Fontanini, Fulvio Basolo, Robert S. Kerbel, Giulio Francia, Romano Danesi, Guido Bocci   +13 more
openalex   +1 more source

Proteomic analysis of the zone of degeneration at the mitosis–meiosis transition stage in wild‐caught male catshark (Scyliorhinus canicula), correlated with an unusually high‐water temperature in the English Channel

Journal of Fish Biology, EarlyView.
Abstract In the context of current global change, variations in water temperature are one of the environmental conditions with serious consequences for marine life, including reproductive processes. In the small spotted catshark Scyliorhinus canicula, spermatogenesis occurs in spermatocysts composed of synchronously developing germ cells associated ...
Fabian Jeanne, Stanislas Pilet, Sean Heighton, Benoît Bernay, Pascal Sourdaine   +4 more
wiley   +1 more source

A genome-wide screen reveals that Dyrk1A kinase promotes nucleotide excision repair by preventing aberrant overexpression of cyclin D1 and p21 [PDF]

, 2023
François Bélanger, Cassandra Roussel, Christina Sawchyn, Edlie St-Hilaire, Sari Gezzar-Dandashi, Aimé Boris Kimenyi Ishimwe, Frédérick A. Mallette, Hugo Würtele, Elliot Drobetsky   +8 more
openalex   +1 more source

Herpesvirus Simplex Virus‐1 Exploits Inflammation to Infect Periodontal Stem Cells and Disrupt Lineage Commitment

Journal of Periodontal Research, EarlyView.
HSV‐1 infects oral mesenchymal stem cells both in vitro and in vivo to dysregulate their lineage commitment. An inflamed gingival environment increases susceptibility to HSV‐1 infection, which further elevates proinflammatory cytokine levels and exacerbates alveolar bone loss.
Araceli Valverde, Raza Ali Naqvi, Yinghua Chen, Alireza Moshaverinia, Anne George, Deepak Shukla, Gloria Martinez, Gabriella Chapa, Salvador Nares, Afsar R. Naqvi   +9 more
wiley   +1 more source

USP10 in Neurological Disorders: Mechanistic Insights and Emerging Therapeutic Strategies

Annals of the New York Academy of Sciences, EarlyView.
USP10 is a deubiquitinating enzyme that affects neurological diseases through multiple mechanisms, including the accumulation of toxic proteins, autophagy, and immune responses. In this review, we discuss the structure and characteristics of USP10 and summarize the role of USP10 in neurological disorders.
Celemuge, Hongying Sun, Jia Zhang, Yang Yang, Jian Mao, Cheliger   +5 more
wiley   +1 more source

Mandibular Condylar Cartilage in Development and Diseases: A PTHrP‐Centric View

Orthodontics &Craniofacial Research, EarlyView.
ABSTRACT The mandibular condylar cartilage (MCC) is a dual‐function component of the temporomandibular joint (TMJ), acting as both articular cartilage for jaw movement and growth cartilage for vertical growth of the mandibular condyle. Parathyroid hormone‐related protein (PTHrP) plays a critical role in orchestrating chondrogenesis in the long bone ...
Chiaki Tsutsumi‐Arai, Amy Tran, Yuki Arai, Wanida Ono, Noriaki Ono   +4 more
wiley   +1 more source

Analysis of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinomas and Paired Normal Mucosae Reveals Cyclin D1 Deregulation and Compensatory Effect of Cyclin D2 [PDF]

, 2020
Jiří Novotný, Veronika Bandúrová, Hynek Strnad, Martin Chovanec, Miluše Hradilová, Jana Šáchová, Martin Šteffl, Josipa Grušanović, Roman Kodet, Václav Pačes, Lukáš Lacina, Karel Smetana, Jan Plzák, Michal Kolář, Tomáš Vomastek   +14 more
openalex   +1 more source

Cancer Hallmarks Expression in Oral Leukoplakia: Systematic Review and Meta‐Analysis

Oral Diseases, EarlyView.
ABSTRACT Objectives To assess the available evidence on the expression of hallmarks of cancer and oral leukoplakia (OL) malignant transformation probability, with the goal of identifying the earliest oncogenic molecular events participating in oral cancer carcinogenesis.
I. González‐Ruiz, P. Ramos‐García, H. Boujemaoui‐Boulaghmoudi, N. Mjouel‐Boutaleb, M. A. González‐Moles   +4 more
wiley   +1 more source

Polo‐like kinases and UV‐induced skin carcinogenesis: What we know and what's next

Photochemistry and Photobiology, EarlyView.
The polo‐like kinase (PLK) family plays distinct and critical roles in the regulation of cell cycle progression, and its dysregulation has been implicated in various cancers. Ultraviolet (UV) radiation is a well‐established environmental factor in the development of skin cancer.
Tanya Jaiswal, Durdana Muntaqua, Gagan Chhabra, Nihal Ahmad   +3 more
wiley   +1 more source

Akt Induces β-Cell Proliferation by Regulating Cyclin D1, Cyclin D2, and p21 Levels and Cyclin-Dependent Kinase-4 Activity [PDF]

, 2006
Szabolcs Fátrai, Lynda Elghazi, Norman Balcázar, Corentin Cras‐Méneur, Irina Krits, Hiroaki Kiyokawa, Ernesto Bernal‐Mizrachi   +6 more
openalex   +1 more source