Results 121 to 130 of about 90,181 (143)
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Cyclin D1 positive follicular lymphoma
Journal of Clinical Pathology, 2009This report describes an unusual case of cyclin D1 expression by an otherwise typical follicular lymphoma, of low histological grade. BCL2–IGH and CCND1–IGH fusions were identified by interphase fluorescence in situ hybridisation.
B, Olsen +4 more
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Cyclin D1 Immunoreactivity in Meningiomas
Cellular and Molecular Neurobiology, 2008Cyclin D1 is an important nuclear protein required for progression of cells through the G1 phase of the cell cycle. The proliferative potential of meningiomas has been studied using various proliferative markers. However, there have been only few published studies evaluating Cyclin D1 immunoreactivity in meningiomas.The aim of our study was to analyze ...
Sanja, Milenković +5 more
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Cinnamaldehydes inhibit cyclin dependent kinase 4/cyclin D1
Bioorganic & Medicinal Chemistry Letters, 2000A series of cinnamaldehydes was synthesized for the study of inhibitory activity against cyclin dependent kinases (CDKs). A couple of compounds selectively inhibited cyclin D1-CDK4 with an IC50 value of 7-18 microM.
H W, Jeong +7 more
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Cyclin D1 in mammary carcinoma
The Journal of Pathology, 1997The control of the cell-cycle-associated protein cyclin D1 and its variable behaviour in normal and transformed cells is described and contrasted with its activity in vivo. The role of cyclin D1 as a prognostic and predictive marker is examined in clinical breast cancer.
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Cyclin D1 in Breast Cancer Pathogenesis
Journal of Clinical Oncology, 2005Taking a perspective on available evidence that emphasizes relevance to human disease, cyclin D1 is solidly established as an oncogene with an important pathogenetic role in breast cancer and other human tumors. However, the precise cellular mechanisms through which aberrant cyclin D1 expression drives human neoplasia are less well established. Indeed,
Andrew, Arnold, Alexandros, Papanikolaou
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Regulation of cyclin D1 gene expression
Biochemical Society Transactions, 2010Cyclin D1 is a key regulator of cell proliferation and its expression is subject to both transcriptional and post-transcriptional regulation. In different cellular contexts, different pathways assume a dominant role in regulating its expression, whereas their disregulation can contribute to overexpression of cyclin D1 in tumorigenesis. Here, we discuss
Ini-Isabée, Witzel +2 more
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Multiple lymphomatous polyposis overexpressing cyclin D1
International Journal of Clinical Oncology, 2000A case of mantle cell lymphoma (MCL) associated with multiple lymphomatous polyposis (MLP) is reported is a 62-year-old woman, with special reference to the patient's clinical features and response to treatment. There were multiple widespread polypoid lesions in the entire gastrointestinal tract, with ileocecal masses. Ileocecal resection was performed
H, Tsujimura +3 more
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Science Signaling, 2001
In response to certain cytokines, signal transducer and activator of transcription (STAT) 3 protein undergoes tyrosine phosphorylation, dimerizes, translocates to the nucleus, and promotes specific gene expression. However, the mechanisms involved in the attenuation of such STAT signaling are not as clear. Bienvenu et al.
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In response to certain cytokines, signal transducer and activator of transcription (STAT) 3 protein undergoes tyrosine phosphorylation, dimerizes, translocates to the nucleus, and promotes specific gene expression. However, the mechanisms involved in the attenuation of such STAT signaling are not as clear. Bienvenu et al.
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Cyclin D1 overexpression in hepatocellular carcinoma
Liver, 2001Abstract: Background/Aims: Cyclin D1 gene amplification and cyclin D1 protein overexpression have been reported in various human tumors, including hepatocellular carcinoma (HCC). However, their significance is still controversial. In the present study, we examined the expression of cyclin D1 and its relationships to p53 and Ki‐67 in HCCs. Methods: The
M, Joo +4 more
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Ras regulation of cyclin D1 promoter
2001Publisher Summary This chapter focuses on the Ras regulation of Cyclin D 1 promoter. Cyclin D l, the regulatory subunit of cyclin-dependent kinases (CDK) 4 and 6, is required for, and capable of, shortening, the G j phase of the cell cycle through the formation of holoenzyme complexes (cyclin-CDK) that phosphorylate retinoblastoma protein (pRB).
D F, Amanatullah +6 more
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