Results 141 to 150 of about 152,964 (318)

MiR‐29a/b Suppresses CD8+ T Cell Effector Function and Intestinal Inflammation

Exploration, EarlyView.
Our findings suggest that miR‐29a/b is a critical regulator of CD8+ T cells, possibly via the Ifng‐JAK‐STAT signal in IBD patients and the upregulation of miR‐29a/b relieves the development of significant inflammation in the colon of DSS‐induced colitis‐affected mice.
Yingying Lin, Yuqi Wang, Yuning Zhang, Yao Lu, Juan Chen, Yongting Luo, Jian He, Qingfeng Luo, Heng Quan, Weiru Yu, Yujia Luo, Peng Xue, Yi Xue, Xiaoya Lin, Rui Ding, Lining Chen, Yiran Wang, Zenghui Xia, Liang Zhao, Hao Zhang, Ran Wang, Qingyu Wang, Xifan Wang, Jiaqi Su, Fazheng Ren, Cong Lv, Yixuan Li, Huiyuan Guo   +27 more
wiley   +1 more source

Functional interaction between the ZO-1-interacting transcription factor ZONAB/DbpA and the RNA processing factor symplekin [PDF]

, 2006
Epithelial tight junctions participate in the regulation of gene expression by controlling the activity of transcription factors that can interact with junctional components.
Balda, MS, Buchert, M, Choquet, A, Hollande, F, Kavanagh, E, Matter, K, Tsapara, A   +6 more
core   +1 more source

Therapeutic targeting of chromatin alterations in leukemia and solid tumors

International Journal of Cancer, EarlyView.
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner, Tobias Berg, Daniel Sasca, Sophie‐Luise Mersiowsky, Jayant Y. Gadrey, Johanna Thomas, Michael W. M. Kühn, Michael Lübbert   +7 more
wiley   +1 more source

Cyclin D1 activation through ATF-2 in Reg-induced pancreatic β-cell regeneration [PDF]

Regenerating gene product (Reg) is induced in pancreatic β-cells and acts as an autocrine/paracrine growth factor for regeneration via a cell surface Reg receptor. However, the manner by which Reg induces β-cell regeneration was unknown.
Akiyama, Akiyo Yamauchi, Beier, D’Amico, Ekholm, Fukui, Gross, Guillemot, Hellerstrom, Hiroshi Okamoto, Horie, Iwao Takahashi, Kageyama, Kato, Kazumori, Kei Nakagawa, Kim, Kim, Kobayashi, Koji Nata, Levine, Livesey, Naoya Noguchi, Nausheen J. Shervani, Nishimune, Okamoto, Okamoto, Okamoto, Rane, Rane, Shin Takasawa, Shoko Murakami-Kawaguchi, Takako Akiyama, Takasawa, Takayuki Ikeda, Taylor, Terazono, Tomoko Tomioka-Kumagai, Unno, Watanabe, Weinberg, Wickramasinghe, Yamamoto, Yan, Yonemura, Zenilman, Zhang   +46 more
core   +1 more source

Regulation of IGF-1-dependent cyclin D1 and E expression by hEag1 channels in MCF-7 cells: The critical role of hEag1 channels in G1 phase progression [PDF]

, 2011
Insulin-like Growth Factor-1 (IGF-1) plays a key role in breast cancer development and cell cycle regulation. It has been demonstrated that IGF-1 stimulates cyclin expression, thus regulating the G1 to S phase transition of the cell cycle. Potassium (K+)
Borowiec, Anne-Sophie, Gouilleux-Gruart, Valérie, Hague, Frédéric, Lassoued, Kaiss, Ouadid-Ahidouch, Halima   +4 more
core   +2 more sources

Applications of bioactive herbal extracts in dressing materials for skin wound repair: Ingredients, mechanisms and innovations

Interdisciplinary Medicine, EarlyView.
Abstract The skin, as the body's largest organ, plays essential roles in protection, immune regulation, and homeostasis. Skin trauma, especially chronic wounds such as diabetic ulcers, poses significant clinical challenges. Traditional treatments, while often effective, can be costly and pose risks.
Boxiang Yang, Jingyuan Xu, Siyi Liu, Chaoying Wu, Yi Li, Mingqi Lv, Tingting Chen, Chuanrong Zhao, Daojun Pu, Chaojun Tang, Anna Malashicheva, Guangchao Zang, Guixue Wang   +12 more
wiley   +1 more source

Patient‐derived xenograft models in pan‐cancer: From bench to clinic

Interdisciplinary Medicine, EarlyView.
Abstract Patient‐derived xenograft (PDX) models provide a robust preclinical platform that preserves the genetic and phenotypic heterogeneity of patient tumors while mirroring their tumor genetic characteristics, which retain malignant cells and the tumor pathological structure, making them valuable for studying tumor progression and developing ...
Jiatong Li, Ao Gu, Nannan Tang, Gokhan Zengin, Meng‐Yao Li, Yingbin Liu   +5 more
wiley   +1 more source

Effects of lovastatin on expression of cell cycle regulatory proteins in vascular smooth muscle cells [PDF]

, 1999
Effects of lovastatin on expression of cell cycle regulatory proteins in vascular smooth muscle cells.BackgroundThe sequential appearance of cyclins D and E is thought to initiate subsequent DNA synthesis in proliferating cells.
Kasiske, Bertram L., Keane, William F., Oda, Hiroaki, O’Donnell, Michael P.   +3 more
core   +1 more source

The Role of Tumor Budding in Early‐Stage Laryngeal Cancer Treatment Selection

The Laryngoscope, EarlyView.
The search for treatment choices in the treatment of early‐stage laryngeal cancer is still ongoing. In this group with high treatment rates, it is important to be able to predict the unsuccessful group in advance. Tumor budding shows promising results. The failure rate after radiotherapy is high in patients with tumor budding of 2 or more.
Mehmet Birinci, Oğuz Gül, Oğuzhan Okcu, Tuğba Yemiş, Bayram Şen, Metin Çeliker, Çiğdem Öztürk, Özlem Çelebi Erdivanlı   +7 more
wiley   +1 more source

Synergistic Inhibition of Prostate Cancer Progression in Mice With a Combination of Curcumin and Ursolic Acid in the Diet

Molecular Carcinogenesis, EarlyView.
ABSTRACT Prostate cancer (PCa) is the second leading cause of cancer‐related death among American men, and its long latency offers a window for chemopreventive strategies. Phytochemicals, with their diverse impacts on cancer cell growth and metabolism, represent promising candidates for such strategies.
Chelsea A. Friedman, Achinto Saha, Rachel Clark, Carly Wilder, Jordan Wright, John DiGiovanni   +5 more
wiley   +1 more source