Results 151 to 160 of about 96,425 (243)

RNA‐Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications

open access: yesMedComm – Oncology, Volume 5, Issue 1, March 2026.
Ferroptosis critically influences cancer cell fate and represents a promising therapeutic strategy. Emerging evidence identifies RNA‐binding proteins (RBPs) as key post‐transcriptional regulators of ferroptosis. The figure summarizes ferroptosis‐related RBPs across cancers: blue RBPs act as tumor suppressors by promoting ferroptosis, whereas red RBPs ...
Linlin Chang   +6 more
wiley   +1 more source

Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation. [PDF]

open access: yesMol Oncol
Cardona-Benavides IJ   +13 more
europepmc   +1 more source

Induction of p53 and melanoma cell death is reciprocal with down‐regulation of E2F, cyclin D1 and pRB [PDF]

open access: bronze, 1998
Manuel Rieber, Mary Strasberg–Rieber
openalex   +1 more source

Rhein Inhibits NLRP3 Activation and Alleviates Microglial Pyroptosis After Intracerebral Hemorrhage in Rats

open access: yesBrain and Behavior, Volume 16, Issue 2, February 2026.
Rhein treatment inhibits NLRP3 inflammasome activation, suppresses Caspase‐1/GSDMD‐mediated pyroptosis, reduces pro‐inflammatory cytokine release, promotes M2 polarization, and improves behavioral outcomes of ICH. These findings suggest that rhein protects against ICH‐induced brain injury through the inhibition of NLRP3‐dependent pyroptosis ...
Adalaiti Aimaiti   +7 more
wiley   +1 more source

Statins in Breast Cancer Therapy: Mechanistic Insights and Emerging Evidence

open access: yesCancer Innovation, Volume 5, Issue 1, February 2026.
Statins, particularly simvastatin, demonstrate potential as adjuvant agents in breast cancer treatment by disrupting tumour cell signalling and survival pathways. This review highlights emerging evidence supporting their repurposing for improved outcomes, especially in aggressive breast cancer subtypes.
Rohina Alim, H. M. Kasuni Akalanka
wiley   +1 more source

Metformin‐Mediated Glycaemic Regulation as a Potential Strategy for Breast Cancer Prevention

open access: yesCancer Medicine, Volume 15, Issue 2, February 2026.
Metformin (MET), a common antihyperglycemic drug, shows promising anti‐cancer effects in breast cancer (BC). It activates adenosine monophosphate‐activated protein kinase (AMPK), regulating cellular energy and inducing cell cycle arrest, anti‐proliferation, and microenvironment alterations.
Ambulugala Gamage Rajika Greshamali Jinadasa   +4 more
wiley   +1 more source

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