RNA‐Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications
Ferroptosis critically influences cancer cell fate and represents a promising therapeutic strategy. Emerging evidence identifies RNA‐binding proteins (RBPs) as key post‐transcriptional regulators of ferroptosis. The figure summarizes ferroptosis‐related RBPs across cancers: blue RBPs act as tumor suppressors by promoting ferroptosis, whereas red RBPs ...
Linlin Chang +6 more
wiley +1 more source
Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation. [PDF]
Cardona-Benavides IJ +13 more
europepmc +1 more source
Induction of p53 and melanoma cell death is reciprocal with down‐regulation of E2F, cyclin D1 and pRB [PDF]
Manuel Rieber, Mary Strasberg–Rieber
openalex +1 more source
Rhein treatment inhibits NLRP3 inflammasome activation, suppresses Caspase‐1/GSDMD‐mediated pyroptosis, reduces pro‐inflammatory cytokine release, promotes M2 polarization, and improves behavioral outcomes of ICH. These findings suggest that rhein protects against ICH‐induced brain injury through the inhibition of NLRP3‐dependent pyroptosis ...
Adalaiti Aimaiti +7 more
wiley +1 more source
ZC3H12D and DDX5 Antagonistically Regulate Cyclin D1 mRNA Stability and Cell Cycle Progression in Breast Cancer. [PDF]
Sun L, Liu X, Lu W.
europepmc +1 more source
Statins in Breast Cancer Therapy: Mechanistic Insights and Emerging Evidence
Statins, particularly simvastatin, demonstrate potential as adjuvant agents in breast cancer treatment by disrupting tumour cell signalling and survival pathways. This review highlights emerging evidence supporting their repurposing for improved outcomes, especially in aggressive breast cancer subtypes.
Rohina Alim, H. M. Kasuni Akalanka
wiley +1 more source
Nano-curcumin enhances the sensitivity of tamoxifen-resistant breast cancer cells via the Cyclin D1-DILA1 axis and the PI3K/AKT/mTOR pathway downregulation. [PDF]
Givi T +6 more
europepmc +1 more source
Metformin‐Mediated Glycaemic Regulation as a Potential Strategy for Breast Cancer Prevention
Metformin (MET), a common antihyperglycemic drug, shows promising anti‐cancer effects in breast cancer (BC). It activates adenosine monophosphate‐activated protein kinase (AMPK), regulating cellular energy and inducing cell cycle arrest, anti‐proliferation, and microenvironment alterations.
Ambulugala Gamage Rajika Greshamali Jinadasa +4 more
wiley +1 more source

