A review on the role of cyclin dependent kinases in cancers [PDF]
Cancer Cell International, 2022 The Cyclin-dependent kinase (CDK) class of serine/threonine kinases has crucial roles in the regulation of cell cycle transition and is mainly involved in the pathogenesis of cancers.
Soudeh Ghafouri-Fard +7 more
doaj +2 more sources
Targeting Protein-Protein Interactions to Inhibit Cyclin-Dependent Kinases [PDF]
Pharmaceuticals, 2023 Cyclin-dependent kinases (CDKs) play diverse and critical roles in normal cells and may be exploited as targets in cancer therapeutic strategies. CDK4 inhibitors are currently approved for treatment in advanced breast cancer.
Mark Klein
doaj +2 more sources
Cyclin-Dependent Kinases (CDK) and Their Role in Diseases Development–Review [PDF]
International Journal of Molecular Sciences, 2021 Cyclin-dependent kinases (CDKs) are involved in many crucial processes, such as cell cycle and transcription, as well as communication, metabolism, and apoptosis.
Izabela Gutowska +2 more
exaly +3 more sources
Gene expression profiles of skin from cyclin dependent kinases 5-knockdown mice [PDF]
Animal BioscienceObjective This study aimed to identify genes regulated by cyclin dependent kinases 5 (CDK5) that participate in hair pigmentation in mice. Methods The mRNA expression profiles of skin samples from CDK5-knockdown mice were constructed using high ...
Shanshan Yang +5 more
doaj +2 more sources
Cyclin-dependent kinases in
Cell Division, 2006 Cell division is an inherent part of organismal development, and defects in this process can lead to developmental abnormalities as well as cancerous growth.
Boxem Mike
doaj +3 more sources
Cyclin-dependent kinases as mediators of aberrant transcription in prostate cancer [PDF]
Translational OncologyTranscriptional control of gene expression is fundamental to all cellular processes. Conversely, transcriptional dysregulation is a hallmark of cancer.
Razia Rahman, Luke A. Selth
doaj +2 more sources
Multi-omics investigation reveals functional specialization of transcriptional cyclin dependent kinases in cancer biology [PDF]
Scientific Reports, 2022 Transcriptional addiction is recognized as a valid therapeutic target in cancer, whereby the dependency of cancer cells on oncogenic transcriptional regulators may be pharmacologically exploited.
Micah G. Donovan +2 more
doaj +2 more sources
Inhibition of cyclin-dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation. [PDF]
Mol OncolThe proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Watlington WK +10 more
europepmc +2 more sources
Ciz1 cooperates with cyclin-A-CDK2 to activate mammalian DNA replication in vitro [PDF]
, 2010 Initiation of mammalian DNA replication can be reconstituted from isolated G1-phase nuclei and cell extracts, supplemented with cyclin-dependent protein kinases (CDKs).
Sercombe, Heather E +3 more
core +4 more sources
Kouqiang hemian waike zazhi, 2023 Oral squamous cell carcinoma (OSCC) is the most common oral and maxillofacial cancer. In‐depth research on the regulatory mechanism of cell cycle regulation‐related molecules has revealed that these molecules play various roles in the incidence and ...
HOU Zeyu, TANG Jinru, LI Longjiang
doaj +1 more source