Results 31 to 40 of about 3,126,054 (284)

Cyclin-dependent kinases [PDF]

Genome Biology, 2014
Summary Cyclin-dependent kinases (CDKs) are protein kinases characterized by needing a separate subunit - a cyclin - that provides domains essential for enzymatic activity. CDKs play important roles in the control of cell division and modulate transcription in response to several extra- and intracellular cues.
openaire   +2 more sources

An In Silico Approach for Potential Natural Compounds as Inhibitors of Protein CDK1/Cks2

Chemistry Proceedings, 2021
CDKs are pivotal mediators essential for the cellular cycle progression. CDKs have relatively constant levels, and their activity is regulated by cyclins, proteins whose concentrations fluctuate during each cell cycle.
Abu Saim Mohammad Saikat
doaj   +1 more source

Analytical description of genetic controlling systems in cells in of proliferation and differentiation states

Біологічні студії, 2015
Paper presents kinetic models of changes in genetic controlling systems of cells in the states of cell proliferation and differentiation. It was shown that the changes in the genetic control of cells in the state of proliferation and differentiation ...
I. V. Stadnyk, D. I. Sanagursky
doaj   +1 more source

Survival-Promoting Activity of Inhibitors of Cyclin-Dependent Kinases on Primary Neurons Correlates with Inhibition of c-Jun Kinase-1

Neurobiology of Disease, 1997
Cyclin-dependent kinases and mitogen-activated protein kinases have been implicated in the regulation of cellular survival and apoptosis. We tested the effect of two mitogen-activated/cyclin-dependent kinase inhibitors, olomoucine and butyrolactone I, on
Marc A. Markus, Philipp J. Kahle, Andrea Winkler, Sonja Horstmann, Johanna M.H. Anneser, Gian Domenico Borasio   +5 more
doaj   +1 more source

Clinical implications and molecular mechanisms of Cyclin-dependent kinases 4 for patients with hepatocellular carcinoma

BMC Gastroenterology, 2022
Background Hepatocellular carcinoma (HCC) was frequently considered as a kind of malignant tumor with a poor prognosis. Cyclin-dependent kinases (CDK) 4 was considered to be cell-cycle-related CDK gene.
Zhong-liu Wei, Xin Zhou, Chen-lu Lan, Hua-sheng Huang, Xi-wen Liao, Shu-tian Mo, Yong-guang Wei, Tao Peng   +7 more
doaj   +1 more source

Assessment of transcript and protein levels contributing to cell cycle control and gap junction connections in morphologically variable groups of porcine cumulus-oocyte complexes

Veterinární Medicína, 2010
Oocytes and somatic cumulus cells are connected by an extensive network of gap junctions. These connections contribute in a major way to oocyte maturation and developmental competence. Cumulus-oocyte complexes (COCs) were cultured in standard porcine IVM
P. Antosik, B. Kempisty, M. Jackowska, H. Piotrowska, D. Bukowska, M. Wozna, M. Lianeri, K.-P. Brussow, J.M. Jaskowski   +8 more
doaj   +1 more source

High throughput screens yield small molecule inhibitors of Leishmania CRK3:CYC6 cyclin-dependent kinase [PDF]

, 2011
<p><b>Background:</b> <i>Leishmania</i> species are parasitic protozoa that have a tightly controlled cell cycle, regulated by cyclin-dependent kinases (CDKs).
Mottram Jeremy C., Thomson, Graeme, Grant Karen M., Turner, N.J., Malcolm D. Walkinshaw, Malone, Kirk, Turner, Nicholas J., Nicholas J Turner, Jeremy C. Mottram, Karen M. Grant, Walker, Roderick G., Graeme Thomson, Malone Kirk, Karen M Grant, Grant, Karen, Nicholas J. Turner, Nowicki, Matthew W., Thomson Graeme, Walkinshaw, M.D., Walkinshaw Malcolm D., David G. Blake, David G Blake, Walker Roderick G., Brown, Elaine, Brown Elaine, Blake David G., Turner Nicholas J., Matthew W. Nowicki, Walker, R.G., Malone, K., Blake, David G., Elaine Brown, Mottram, J.C., Kirk Malone, Walkinshaw, Malcolm D., Matthew W Nowicki, Brown, E., Nowicki Matthew W., Turner, Nicholas J.; id_orcid, Grant, Karen M., Grant, K.M., Mottram, Jeremy C., Roderick G Walker, Jeremy C Mottram, Roderick G. Walker, Nowicki, M.W., Blake, D.G., Malcolm D Walkinshaw, Thomson, G.   +48 more
core   +2 more sources

Physicochemical Properties of analogs α-Aminophosphonates Drugs Determined via Molecular Dynamics Simulation

Asian Pacific Journal of Cancer Biology, 2019
Objective: Cyclin-dependent kinases (CDKs, play important roles in cell cycle regulation. Since deregulation of cyclins and/or alteration or absence of inhibitors has been associated with many cancers, there is strong interest in CDKs inhibitors that ...
Reihaneh Sabbaghzadeh
doaj   +1 more source

The cyclin dependent kinase inhibitor Roscovitine prevents diet-induced metabolic disruption in obese mice

Scientific Reports, 2021
Most strategies to treat obesity-related disorders have involved prevention of diet-induced weight gain in lean mice. Treatment of obese individuals will require therapies that reverse the detrimental effects of excess body weight.
Nabil Rabhi, Kathleen Desevin, Briana Noel Cortez, Ryan Hekman, Jean Z. Lin, Andrew Emili, Stephen R. Farmer   +6 more
doaj   +1 more source

Cyclin-dependent kinases-based synthetic lethality: Evidence, concept, and strategy

Acta Pharmaceutica Sinica B, 2021
Synthetic lethality is a proven effective antitumor strategy that has attracted great attention. Large-scale screening has revealed many synthetic lethal genetic phenotypes, and relevant small-molecule drugs have also been implemented in clinical ...
Kailin Li, Jieqiong You, Qian Wu, Wen Meng, Qiaojun He, Bo Yang, Chengliang Zhu, Ji Cao   +7 more
doaj   +1 more source