Results 61 to 70 of about 95,731 (301)

A divergent cyclin/cyclin-dependent kinase complex controls the atypical replication of a malaria parasite during gametogony and transmission

eLife, 2020
Cell cycle transitions are generally triggered by variation in the activity of cyclin-dependent kinases (CDKs) bound to cyclins. Malaria-causing parasites have a life cycle with unique cell-division cycles, and a repertoire of divergent CDKs and cyclins ...
Aurélia C Balestra, Mohammad Zeeshan, Edward Rea, Carla Pasquarello, Lorenzo Brusini, Tobias Mourier, Amit Kumar Subudhi, Natacha Klages, Patrizia Arboit, Rajan Pandey, Declan Brady, Sue Vaughan, Anthony A Holder, Arnab Pain, David JP Ferguson, Alexandre Hainard, Rita Tewari, Mathieu Brochet   +17 more
doaj   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Inhibition of cyclin-dependent kinases by purine analogues [PDF]

, 1994
While testing purines related to the non-specific protein kinase inhibitors N6-dimethylaminopurine and N6-(delta2-isopentenyl)adenine as potential inhibitors of the p34cdc2/cyclin B kinase, we discovered a compound with high specificity, 2-(2 ...
Strnad, Miroslav, David S. Letham, DONELLA, ARIANNA, Jun-ya Kat, Leclerc, Sophie, Lcnayck Detkvaud, Havlicek, Libor, Detivaud, Lenaick, Miroslav Strnad, Laurent Meijer, Kato J, Strnad M, Meijer, Laurent, Leclerc S., J. Julian Blow, Kato, Jun-ya, Detivaud L, Blow, J. Julian; id_orcid, Arianna Donella-deana, Letham, David S., Lorenzo Pinna, Havlicek L, Pinna, Lorenzo, Letham DS, Sophie Leclerc, Veselý J, Blow JJ, Blow, J. Julian, Donella-Deana, Arianna, Libor Havlieek, Veselý, Jaroslav, Jaroslav Vesely   +31 more
core   +1 more source

STRUCTURAL BIOINFORMATICS STUDY OF CYCLIN-DEPENDENT KINASES COMPLEXED WITH INHIBITORS

Eclética Química, 2018
The present work describes molecular models for the binary complexes CDK9, CDK5 and CDK1 complexed with Flavopiridol and Roscovitine. These structural models indicate that the inhibitors strongly bind to the ATP-binding pocket of CDKs and the structural ...
F. CANDURI, N. J. F. da SILVEIRA, J. C. CAMERA JR, W. F. W. F. dd   +3 more
doaj   +1 more source

Distinct expression pattern and post-transcriptional regulation of cell cycle genes in the glandular epithelia of avian ovarian carcinomas. [PDF]

PLoS ONE, 2012
The cell cycle system is controlled in a timely manner by three groups of cyclins, cyclin dependent kinases and cyclin dependent kinase inhibitors. Abnormal alterations of cell cycle regulatory mechanisms are a common feature of many diseases including ...
Jin-Young Lee, Wooyoung Jeong, Ji-Hye Kim, Jinyoung Kim, Fuller W Bazer, Jae Yong Han, Gwonhwa Song   +6 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Are all cyclin-dependent kinases 4/6 inhibitors created equal? [PDF]

, 2019
The harnessing in clinical practice of cyclin-dependent kinases 4/6 inhibitors, namely palbociclib, ribociclib, and abemaciclib, has substantially changed the therapeutic approach for hormone receptor-positive metastatic breast cancer (BC).
Marra, Antonio, Curigliano, Giuseppe
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Cyclin E/CDK2: DNA Replication, Replication Stress and Genomic Instability

Frontiers in Cell and Developmental Biology, 2021
DNA replication must be precisely controlled in order to maintain genome stability. Transition through cell cycle phases is regulated by a family of Cyclin-Dependent Kinases (CDKs) in association with respective cyclin regulatory subunits. In normal cell
Rafaela Fagundes, Leonardo K. Teixeira
doaj   +1 more source