Results 241 to 250 of about 37,065 (297)

Targeting CDK2 for cancer therapy. [PDF]

Cell Rep
Knudsen ES, Witkiewicz AK, Sanidas I, Rubin SM.   +3 more
europepmc   +1 more source

Structural Insights Into the Function of Leishmania major Adenylosuccinate Lyase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT One of several intriguing aspects of kinetoplastid biochemistry is the complete dependence on host purines and purine recycling due to the lack of a de novo purine biosynthesis pathway. Adenylosuccinate lyase (ASL, EC 4.3.2.2) is a key enzyme in the purine synthesis pathway responsible for the conversion of adenylosuccinate into adenosine ...
Ivan R. e Silva, Monique Mantovani, Maria E. S. D. Lino, Aline O. Albuquerque, João H. M. da Silva, Ronaldo A. P. Nagem, Adriana L. Rojas, Geraldo R. Sartori, Eduardo Horjales, David Campbell, Otavio H. Thiemann   +10 more
wiley   +1 more source

Differences in Binding Affinity Among Cell-cycle CDK and Cyclin Pairs. [PDF]

J Mol Biol
Putta S, Villegas CA, Rubin SM.
europepmc   +1 more source

Capacity for Compensatory Cyclin D2 Response Confers Trametinib Resistance in Canine Mucosal Melanoma. [PDF]

Cancers (Basel)
Wei BR, Verdi V, Zhang S, Mock BA, Shive HR, Simpson RM.   +5 more
europepmc   +1 more source

G0 or no-G0: phosphatase control of quiescence and cell cycle entry. [PDF]

Biochem Soc Trans
Robinson EA, Barr AR.
europepmc   +1 more source

The recruitment of the A-type cyclin TAM to stress granules is crucial for meiotic fidelity under heat. [PDF]

Sci Adv
De Jaeger-Braet J, Hartmann M, Böttger L, Yang C, Hamada T, Hoth S, Feng X, Weingartner M, Schnittger A.   +8 more
europepmc   +1 more source

Dinaciclib Interrupts Cell Cycle and Induces Apoptosis in Oral Squamous Cell Carcinoma: Mechanistic Insights and Therapeutic Potential. [PDF]

Int J Mol Sci
Oner M, Cheng YC, Soong SW, Cheng PT, Wang YH, Yang SF, Tsai SC, Lin H.   +7 more
europepmc   +1 more source

The minimal cell-cycle control system in Marchantia as a framework for understanding plant cell proliferation

Romani F, Bonter I, Rebmann M, Takahashi G, Guzman-Chavez F, De Batté F, Hirakawa Y, Haseloff J.   +7 more
europepmc   +1 more source

Kinase-independent function of E-type cyclins in liver cancer

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Amplification of the cyclin E genes and overexpression of cyclin E proteins is very frequent in several human tumor types. In particular, overexpression of E cyclins was implicated in the pathogenesis of liver cancers. According to
Wojciech Michowski, Joel M Chick, Yaoyu E Wang   +2 more
exaly   +2 more sources