Results 21 to 30 of about 831,285 (343)

DNA cyclization and looping in the wormlike limit: normal modes and the validity of the harmonic approximation [PDF]

, 2015
For much of the last three decades Monte Carlo-simulation methods have been the standard approach for accurately calculating the cyclization probability, $J$, or J factor, for DNA models having sequence-dependent bends or inhomogeneous bending ...
Alexandrowicz, Brackley, Chaumeil, Crothers, Flory, Flory, Gennes, Giovan, Guo, Hagerman, Hagerman, Hensel, Hill, Hockings, Hou, Kahn, Kahn, Koo, Kulaeva, Levene, Levene, Levene, Levene, Marini, May, Nathan, Olson, Olson, Polikanov, Reichl, Roychoudhury, Sanyal, Shimada, Shimada, Shore, Shore, Shore, Swigon, Tokuda, Wu, Zhang, Zhang, Zhang, Zhang   +43 more
core   +3 more sources

Synthesis and investigation on optical and electrochemical properties of 2,4-diaryl-9-chloro-5,6,7,8-tetrahydroacridines

Beilstein Journal of Organic Chemistry, 2021
A facile synthesis of 2,4-diaryl-9-chloro-5,6,7,8-tetrahydroacridine derivatives is reported which is based on POCl3-mediated cyclodehydration followed by double Suzuki–Miyaura cross-coupling.
Najeh Tka, Mohamed Adnene Hadj Ayed, Mourad Ben Braiek, Mahjoub Jabli, Peter Langer   +4 more
doaj   +1 more source

Iodoarene-Catalyzed Cyclizations of Unsaturated Amides [PDF]

, 2015
The cyclization of N-alkenylamides catalyzed by iodoarenes under oxidative conditions is presented. Five-, six-, and seven-membered rings with a range of substitutions can be prepared by this route.
Ali Alhalib, Bode H. B., Degnan B. M., Dohi T., Dohi T., Fujita M., Fujita M., Guilbault A.-A., Guilbault A.-A., Hamnett D. J., Kong A., Mizar P., Moon N. G., Murai T., Ngatimin M., Parra A., Richardson R. D., Rodríguez A., Rodríguez A., Shimogaki M., Somaia Kamouka, Suzuki S., Uyanik M., Uyanik M., Wesley J. Moran, Wu H., Yan J., Zhdankin V. V., Zheng Z. S., Zhong W., Zhou Z.-S.   +30 more
core   +1 more source

Synthesis and Biological Activities of Pyrazino[1,2-a]indole and Pyrazino[1,2-a]indol-1-one Derivatives

Pharmaceuticals, 2021
This review concerns the synthesis and biological activities of pyrazino[1,2-a]indoles and pyrazino[1,2-a]indol-1-ones reported since 1997 and the discovery of biological activity of pyrazinoindole derivatives.
Kena Zhang, Christine Tran, Mouad Alami, Abdallah Hamze, Olivier Provot   +4 more
doaj   +1 more source

Engineering of Cyclodextrin Product Specificity and pH Optima of the Thermostable Cyclodextrin Glycosyltransferase from Thermoanaerobacterium thermosulfurigenes EM1 [PDF]

, 1998
The product specificity and pH optimum of the thermostable cyclodextrin glycosyltransferase (CGTase) from Thermoanaerobacterium thermosulfurigenes EM1 was engineered using a combination of x-ray crystallography and site-directed mutagenesis.
Bauke W. Dijkstra, Bhat, Bradford, Brünger, Davies, Engh, Fujiwara, Haeckel, Harata, Jones, Joost C.M. Uitdehaag, Kabsch, Klein, Klein, Kleywegt, Knegtel, Knegtel, Koshland, Lamzin, Laskowski, Lawson, Lazzaroni, Lubbert Dijkhuizen, Monma, Nakamura, Nakamura, Norman, Pedersen, Penninga, Qian, Read, Reinetta M. Buitelaar, Richèle D. Wind, Sambrook, Sanger, Schmid, Starnes, Strokopytov, Strokopytov, Svensson, Takase, Takusagawa, Tronrud, Wind, Yanisch-Perron   +44 more
core   +2 more sources

Changing the topology of protein backbone: the effect of backbone cyclization on the structure and dynamics of a SH3 domain

Frontiers in Chemistry, 2015
Understanding of the effects of the backbone cyclization on the structure and dynamics of a protein is essential for using protein topology engineering to alter protein stability and function.
Frank H Schumann, Ranjani eVaradan, Praveen Pudiavettil Tayakuniyil, Jennifer Hall Grossman, Julio A Camarero, Julio A Camarero, David eFushman   +6 more
doaj   +1 more source

Kinetics of Loop Formation in Polymer Chains [PDF]

, 2007
We investigate the kinetics of loop formation in flexible ideal polymer chains (Rouse model), and polymers in good and poor solvents. We show for the Rouse model, using a modification of the theory of Szabo, Schulten, and Schulten, that the time scale ...
Hyeon, Changbong, Morrison, Greg, Thirumalai, D., Toan, Ngo Minh   +3 more
core   +2 more sources

Simultaneous cyclization and derivatization of peptides using cyclopentenediones [PDF]

, 2017
Unprotected linear peptides containing N-terminal cysteines and another cysteine residue can be simultaneously cyclized and derivatized using 2,2-disubstituted cyclopentenediones. High yields of cyclic peptide conjugates may be obtained in short reaction
Agramunt, Jordi, Archibald, Lewis J., Brun, Omar, Grandas, Anna, Pedroso, Enrique   +4 more
core   +2 more sources

Nucleophilic and electrophilic cyclization of N-alkyne-substituted pyrrole derivatives: Synthesis of pyrrolopyrazinone, pyrrolotriazinone, and pyrrolooxazinone moieties

Beilstein Journal of Organic Chemistry, 2017
Intramolecular nucleophilic and electrophilic cyclization of N-alkyne-substituted pyrrole esters is described. Efficient routes towards the synthesis of pyrrolopyrazinone, pyrrolotriazinone and pyrrolooxazinone have been developed.
Işıl Yenice, Sinan Basceken, Metin Balci   +2 more
doaj   +1 more source

Neutral and Cationic Rare Earth Metal Alkyl and Benzyl Compounds with the 1,4,6-Trimethyl-6-pyrrolidin-1-yl-1,4-diazepane Ligand and Their Performance in the Catalytic Hydroamination/Cyclization of Aminoalkenes [PDF]

, 2008
A new neutral tridentate 1,4,6-trimethyl-6-pyrrolidin-1-yl-1,4-diazepane (L) was prepared. Reacting L with trialkyls M(CH2SiMe3)3(THF)2 (M = Sc, Y) and tribenzyls M(CH2Ph)3(THF)3 (M = Sc, La) yielded trialkyl complexes (L)M(CH2SiMe3)3 (M = Sc, 1; M = Y ...
Arndt S., Arndt S., Bambirra S., Bambirra S., Bambirra S., Bambirra S., Bambirra S., Bambirra S., Bambirra S., Bambirra S., Booij M., Carver C. T., De Kimpe N., Douglass M. R., Douglass M. R., Evans W. J., Gagné M. R., Gagné M. R., Gao W., Ge S, Ge S., Ge S., Ge S., Giardello M. A., Gribkov D. V., Hajela S., Hayes P. G., Hong S, Horino Y., Howe R. G., Kawaoka A. M., Kim J. Y., Komeyama K., Lappert M. F., Lauterwasser F., Lawrence S. C., Li W., Liu Y., Lukesova L., Lukesova L., Meyer N., Meyer N., Molander G. A., Molander G. A., Nishiura M., Robert D., Ryu J. -S, Sakakura Y., Shannon R. D., Stubbert B. D., Tardif O., Tazelaar C. G. J., Tokuda M., Tredget C. S., Trifonov A. A, Wang Q., Ward B. D., Yu P. F., Yuen H. F., Zeimentz P. M., Zhang L.   +60 more
core   +3 more sources