Harnessing the cyclization strategy for new drug discovery
Acta Pharmaceutica Sinica B, 2022 The design of new ligands with high affinity and specificity against the targets of interest has been a central focus in drug discovery. As one of the most commonly used methods in drug discovery, the cyclization represents a feasible strategy to ...
Kai Tang +4 more
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The gas phase cyclization of deprotonated N-aryl-2-cyano-2-diazoacetamides [PDF]
, 2005 The document attached has been archived with permission from the publisher.1-Aryl-4-cyano-5-hydroxy-1,2,3-triazoles can be obtained in solution by base-catalysed cyclization of N-aryl-2-cyano-2-diazoacetamides.
Bilusich, D. +6 more
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Synthesis and investigation of solvent effects on the ultraviolet absorption spectra of 5-substituted-4-methyl-3-cyano-6-hydroxy-2-pyridones [PDF]
Journal of the Serbian Chemical Society, 2001 A number of 5-substituted-4-methyl-3-cyano-6-hydroxy-2-pyridones from cyanoacetamide and the corresponding alkyl ethyl acetoacetates were synthesized according to modified literature procedures. The alkyl ethyl acetoacetates were obtained by the
Mijin Dušan Ž. +2 more
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Cyclic Peptoid-Peptide Hybrids as Versatile Molecular Transporters
Frontiers in Chemistry, 2021 Addressing intracellular targets is a challenging task that requires potent molecular transporters capable to deliver various cargos. Herein, we report the synthesis of hydrophobic macrocycles composed of both amino acids and peptoid monomers. The cyclic
Claudine Nicole Herlan +6 more
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The iso-Nazarov reaction [PDF]
, 2017 The construction of five-membered rings is essential in organic chemistry. In this context, pentannulation reactions that provide a straightforward access to cyclopentenones are of particular interest, as these structures are not only embedded in ...
Marsili, Lucía A. +2 more
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Frontiers in Chemistry, 2015 Understanding of the effects of the backbone cyclization on the structure and dynamics of a protein is essential for using protein topology engineering to alter protein stability and function.
Frank H Schumann +6 more
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Enzymatic Bromocyclization of α‐ and γ‐Allenols by Chloroperoxidase from Curvularia inaequalis
ChemistryOpen, 2022 Vanadate‐dependent chloroperoxidase from Curvularia inaequalis catalyzes 5‐endo‐trig bromocyclizations of α‐allenols to produce valuable halofunctionalized furans as versatile synthetic building blocks. In contrast to other haloperoxidases, also the more
Janne M. Naapuri +3 more
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6-Endo-dig cyclization: Flexible enforce to develop synthetic route in organic syntheses
Results in Chemistry, 2023 The organic ring closure reaction of diverse acyclic compounds is governed mostly by the Baldwin rule. The ring closure compounds shows emergent application.
Vembu Yogeshwaran +3 more
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Syntheses of (+)-30-epi-, (-)-6-epi-, (±)-6,30-epi-13,14-didehydroxyisogarcinol and (±)-6,30-epi-garcimultiflorone A utilizing highly diastereoselective, Lewis acid-controlled cyclizations [PDF]
, 2016 The first syntheses of 13,14-didehydroxyisogarcinol (6) and garcimultiflorone A (5) stereoisomers are reported in six steps from a commercially available phloroglucinol.
Boyce, Jonathan H. +2 more
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Beilstein Journal of Organic Chemistry, 2017 Intramolecular nucleophilic and electrophilic cyclization of N-alkyne-substituted pyrrole esters is described. Efficient routes towards the synthesis of pyrrolopyrazinone, pyrrolotriazinone and pyrrolooxazinone have been developed.
Işıl Yenice +2 more
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