Results 21 to 30 of about 2,874,801 (150)

Nucleophilic and electrophilic cyclization of N-alkyne-substituted pyrrole derivatives: Synthesis of pyrrolopyrazinone, pyrrolotriazinone, and pyrrolooxazinone moieties

Beilstein Journal of Organic Chemistry, 2017
Intramolecular nucleophilic and electrophilic cyclization of N-alkyne-substituted pyrrole esters is described. Efficient routes towards the synthesis of pyrrolopyrazinone, pyrrolotriazinone and pyrrolooxazinone have been developed.
Işıl Yenice, Sinan Basceken, Metin Balci   +2 more
doaj   +1 more source

6-Endo-dig cyclization: Flexible enforce to develop synthetic route in organic syntheses

Results in Chemistry, 2023
The organic ring closure reaction of diverse acyclic compounds is governed mostly by the Baldwin rule. The ring closure compounds shows emergent application.
Vembu Yogeshwaran, Senthilkumar Dhayanithi, Periasamy Vinoth Kumar, Selvaraj Mohana Roopan   +3 more
doaj  

Cyclic Peptoid-Peptide Hybrids as Versatile Molecular Transporters

Frontiers in Chemistry, 2021
Addressing intracellular targets is a challenging task that requires potent molecular transporters capable to deliver various cargos. Herein, we report the synthesis of hydrophobic macrocycles composed of both amino acids and peptoid monomers. The cyclic
Claudine Nicole Herlan, Anna Meschkov, Anna Meschkov, Ute Schepers, Ute Schepers, Stefan Bräse, Stefan Bräse   +6 more
doaj   +1 more source

Visible-Light-Mediated Generation of Nitrogen-Centered Radicals: Metal-Free Hydroimination and Iminohydroxylation Cyclization Reactions

Angewandte Chemie, 2015
The formation and use of iminyl radicals in novel and divergent hydroimination and iminohydroxylation cyclization reactions has been accomplished through the design of a new class of reactive O-aryl oximes.
Jacob Davies, S. Booth, Stéphanie Essafi, R. Dryfe, Daniele Leonori   +4 more
semanticscholar   +1 more source

Synthesis and investigation of solvent effects on the ultraviolet absorption spectra of 5-substituted-4-methyl-3-cyano-6-hydroxy-2-pyridones [PDF]

Journal of the Serbian Chemical Society, 2001
A number of 5-substituted-4-methyl-3-cyano-6-hydroxy-2-pyridones from cyanoacetamide and the corresponding alkyl ethyl acetoacetates were synthesized according to modified literature procedures. The alkyl ethyl acetoacetates were obtained by the
Mijin Dušan Ž., Ušćumlić Gordana S., Valentić Nataša V.   +2 more
doaj   +1 more source

Catalyst-Dependent Chemoselectivity in the Dirhodium-Catalyzed Cyclization Reactions Between Enodiazoacetamide and Nitrosoarene: A Theoretical Study

Frontiers in Chemistry, 2019
N-O heterocycle compounds play an important role in various fields. Doyle et al. (Cheng et al., 2017) have recently reported an efficient catalyst-controlled selective cyclization reactions of tert-butyldimethylsilyl (TBS)-protected enoldiazoacetamides ...
Yan Zhang, Yongsheng Yang, Ruyu Zhu, Xingyu Wang, Ying Xue   +4 more
doaj   +1 more source

Iminoboronate-Based Peptide Cyclization That Responds to pH, Oxidation, and Small Molecule Modulators.

Journal of the American Chemical Society, 2016
As a rich source of therapeutic agents, peptide natural products usually adopt a cyclic or multicyclic scaffold that minimizes structural flexibility to favor target binding.
A. Bandyopadhyay, Jianmin Gao
semanticscholar   +1 more source

Hypervalent iodine-mediated cyclization of bishomoallylamides to prolinols

Beilstein Journal of Organic Chemistry
A change in mechanism was observed in the hypervalent iodine-mediated cyclization of N-alkenylamides when the carbon chain between the alkene and the amide increased from two to three atoms.
Smaher E. Butt, Konrad Kepski, Jean-Marc Sotiropoulos, Wesley J. Moran   +3 more
doaj   +1 more source

Natural Occurring and Engineered Enzymes for Peptide Ligation and Cyclization

Frontiers in Chemistry, 2019
The renaissance of peptides as prospective therapeutics has fostered the development of novel strategies for their synthesis and modification. In this context, besides the development of new chemical peptide ligation approaches, especially the use of ...
Timo Nuijens, Ana Toplak, Marcel Schmidt, Antonio Ricci, Walter Cabri, Walter Cabri   +5 more
doaj   +1 more source

Synthesis and Spectral Study of a New Family of 2,5-Diaryltriazoles Having Restricted Rotation of the 5-Aryl Substituent

Molecules, 2020
Efficient synthesis of 2,5-diaryl substituted 4-azido-1,2,3-triazoles by the reaction of sodium azide with dichlorosubstituted diazadienes was demonstrated.
Biligma Tsyrenova, Valentine Nenajdenko
doaj   +1 more source