Results 51 to 60 of about 164,620 (294)

Nickel-catalyzed switchable arylative/endo-cyclization of 1,6-enynes

Nature Communications
Carbo- and heterocycles are frequently used as crucial scaffolds in natural products, fine chemicals, and biologically and pharmaceutically active compounds.
Wenfeng Liu, Wei Li, Weipeng Xu, Minyan Wang, Wangqing Kong   +4 more
doaj   +1 more source

Natural Occurring and Engineered Enzymes for Peptide Ligation and Cyclization

Frontiers in Chemistry, 2019
The renaissance of peptides as prospective therapeutics has fostered the development of novel strategies for their synthesis and modification. In this context, besides the development of new chemical peptide ligation approaches, especially the use of ...
Timo Nuijens, Ana Toplak, Marcel Schmidt, Antonio Ricci, Walter Cabri, Walter Cabri   +5 more
doaj   +1 more source

Synthesis of 4-(Phenylchalcogenyl)tetrazolo[1,5-a]quinolines by Bicyclization of 2-Azidobenzaldehydes with Phenylchalcogenylacetonitrile

Molecules, 2023
A general methodology to access valuable 4-(phenylchalcogenyl)tetrazolo[1,5-a]quinolines was developed by the reaction of 2-azidobenzaldehyde with phenylchalcogenylacetonitriles (sulfur and selenium) in the presence of potassium carbonate (20 mol%) as a ...
Loana I. Monzon, Nicole C. M. Rocha, Gabriela T. Quadros, Pâmela P. P. Nunes, Roberta Cargnelutti, Raquel G. Jacob, Eder J. Lenardão, Gelson Perin, Daniela Hartwig   +8 more
doaj   +1 more source

Oxidative Azo–Ene Cyclization

Organic Letters, 2016
An expedient procedure for catalytic oxidative azo-ene cyclization of allylic and homoallylic 1,2-hydrazinedicarboxylates is reported. The reaction produced a wide range of cyclic carbamate derivatives featuring an appended alkene fragment ready for further functionalization.
Nolwenn Derrien, James S. Sharley, Aleksandr E. Rubtsov, Andrei V. Malkov   +3 more
openaire   +4 more sources

A Generalized Theory of DNA Looping and Cyclization [PDF]

, 2009
We have developed a generalized semi-analytic approach for efficiently computing cyclization and looping $J$ factors of DNA under arbitrary binding constraints. Many biological systems involving DNA-protein interactions impose precise boundary conditions
Meiners, Jens-Christian, Tkachenko, Alexei V., Wilson, David P.   +2 more
core   +2 more sources

An Efficient Synthesis of Novel 4-Aryl-2-thioxo-3,4-dihydro-1H-pyrimido[1,2-a][1,3,5]triazin-6(2H)-ones and Their Antibacterial Activity

Molbank, 2022
New substituted 4-aryl-8-methyl-2-thioxo-1,2,3,4-tetrahydro-6H-pyrimido[1,2-a][1,3,5]triazin-6-one 8a–b and ethyl 4-aryl-6-oxo-2-thioxo-1,3,4,6-tetrahydro-2H-pyrimido[1,2-a][1,3,5]triazine-7-carboxylate 8c–e were synthesized by the reaction of the ...
Do Van Quy, Nguyen Van Hung, Nadezhda Stolpovskaya, Aleksey Kruzhilin, Svetlana S. Olshannikova, Marina Holyavka, Vladimir Sulimov, Khidmet Shikhaliev   +7 more
doaj   +1 more source

Enantioselective cyclizations and cyclization cascades of samarium ketyl radicals

Nature Chemistry, 2017
The rapid generation of molecular complexity from simple starting materials is a key challenge in synthesis. Enantioselective radical cyclization cascades have the potential to deliver complex, densely packed, polycyclic architectures, with control of three-dimensional shape, in one step.
Nicolas Kern, Mateusz P. Plesniak, Joseph J. W. McDouall, David J. Procter   +3 more
openaire   +5 more sources

Trypsin inhibition by macrocyclic and open-chain variants of the squash inhibitor MCoTI-II [PDF]

, 2005
MCoTl-I and MCoTl-II from the seeds of Momordica cochinchinensis are inhibitors of trypsin-like proteases and the only known members of the large family of squash inhibitors that are cyclic and contain an additional loop connecting the amino- and the ...
Avrutina, Olga, Diederichsen, Ulf, Gabrijelcic-Geiger, Dusica, Kolmar, Harald, Le Nguyen, Dung, Schmoldt, Hans-Ulrich, Sommerhoff, Christian P.   +6 more
core   +1 more source

Implementing Health‐Related Quality of Life Assessment in Pediatric Oncology: A Feasibility Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background There is growing interest in embedding health‐related quality of life (HRQoL) assessment and patient‐reported outcome measures (PROMs) within clinical cancer care. This study evaluated the feasibility, acceptability, and usability of implementing an electronic PROM (ePROM) platform to measure HRQoL in children with cancer ...
Mikaela Doig, Sophie Jessop, Jordan R. Hansford, Hien Le, Matthew O'Connor, Peter Gorayski, Andrew Cunningham, Amanda Hutchinson, Victoria Bedford, Eva Bezak, Nayana Parange, Kelly Skelton, Timothy Price, Michala Short   +13 more
wiley   +1 more source

A reagent-free, sequence-dependent in situ peptide self-cyclization strategy under physiological condition

European Journal of Medicinal Chemistry Reports
Cyclic peptides are an important class of bioactive molecules used as drugs as well as biomolecular probes. Peptide cyclization under the physiological environment, without added chemicals or reagents, would be a highly useful technique for in situ ...
Nibedita Ghosh, Lal Mohan Kundu
doaj   +1 more source