Results 171 to 180 of about 27,486 (241)

Ratiometric pH‐Responsive and Biomimetic Microparticles for Quantitative Monitoring of Phagosomal Acidification

Chemistry – A European Journal, EarlyView.
A series of hydrosoluble BODIPY pH probes allows building biomimetic pH sensors based on micrometric oil‐in‐water droplets. The ratiometric fluorescence output offers quantitative information on the evolution of pH during phagosome maturation. ABSTRACT We present a modular biomimetic fluorescent sensing platform designed to precisely interrogate the ...
Sophie Michelis, Héloïse Uhl, Florence Niedergang, Jacques Fattaccioli, Blaise Dumat, Jean‐Maurice Mallet   +5 more
wiley   +1 more source

The Diarylprolinol Silyl Ethers: After 20 Years Still Opening New Doors in Asymmetric Catalysis. [PDF]

Angew Chem Int Ed Engl
Marcantonio E, Bitsch RS, Jørgensen KA.
europepmc   +1 more source

Extracellularly Activatable Conjugates of RGD Peptidomimetics and Cryptophycin for αVβ3‐Targeted Cancer Therapy

Chemistry – A European Journal, EarlyView.
Integrin αVβ3‐targeting small‐molecule drug conjugates (SMDCs) were synthesized by conjugating a cryptophycin payload through a neutrophil elastase‐cleavable NPV‐PABC linker. RGD peptidomimetic and linker epimers served as controls for targeting and enzymatic cleavage, and the resulting conjugates displayed subnanomolar cytotoxicity in vitro.
Dominic Seißenschmidt, Henriette Hartung, Jonah Kammer, Norbert Sewald   +3 more
wiley   +1 more source

Asymmetric Total Synthesis of (-)-Verrucarol. [PDF]

Angew Chem Int Ed Engl
Powers MH, McCleerey JF, Bacon JW, McNeely J, Zhang W, Porco JA.   +5 more
europepmc   +1 more source

Peptide Marriages: Modular Assembly of Multi‐Agonist Therapeutics

Chemistry – A European Journal, EarlyView.
A modular polyethylene glycol (PEG) scaffold enables rapid assembly of dual peptide agonists using strain‐promoted azide–alkyne cycloaddition (SPAAC) and copper‐catalysed azide–alkyne cycloaddition (CuAAC). Glucagon‐like peptide‐1 (GLP‐1) and amylin agonists were combined with controlled valency, yielding low‐picomolar activity and receptor‐selective ...
Kristina A. Kostadinova, Jan L. Venne, Sona Krajcovicova, James Dodgson, Wouter F. J. Hogendorf, Thomas E. Nielsen, David Hymel, Hannah Bolt, Andie Collinson, Jason Day, Jefferson Revell, David R. Spring   +11 more
wiley   +1 more source

Radical/Ylide-Tunable Pyridinium Salt Enables Photo/Thermocatalytic Divergent [3 + 2] Cycloadditions. [PDF]

JACS Au
Sun F, Kuang Y, Wu X, Lin Z, Huang Z, Liu B, Li G, Zhang M, Hong L.   +8 more
europepmc   +1 more source

Assembly of CF₃-Pyrazole-Triazole Hybrids through (3 + 3)-Cycloaddition/Ring Contraction and Click Chemistry. [PDF]

J Org Chem
Świątek K, Utecht-Jarzyńska G, Olszewska B, Gach-Janczak K, Jasiński M.   +4 more
europepmc   +1 more source

Electrochemically driven strain-release dearomative (3 + 2) cyclization for the synthesis of bicyclo[2.1.1]hexane-fused polycyclic spiroindolines. [PDF]

Chem Sci
Zhu Y, Pu E, Yang S, Zhao D, Xu Q, Jiang P, Li X, Zhang H, Chen J.   +8 more
europepmc   +1 more source

Creating molecular complexity in the chemoenzymatic synthesis of chlorothricin analogues using tandem Diels-Alderases.

Org Biomol Chem
Devine AJ, Manzo-Ruiz M, Back CR, Zorn K, Hayes MA, Race PR, Willis CL.   +6 more
europepmc   +1 more source

Biocatalytic Epoxidation Pathway of Oils in Sponge-Like Ionic Liquids Toward CO₂-Derived Cyclic Carbonate Synthesis. [PDF]

ChemSusChem
Ruiz FJ, Villa R, Velasco F, Parra J, Nieto S, Garcia-Verdugo E, Dupont J, Lozano P.   +7 more
europepmc   +1 more source