Results 181 to 190 of about 82,507 (282)

1-Naphthyl-TADDOL/Emim BF4: A new catalytic system for the asymmetric addition of Chan’s diene to aromatic aldehydes

open access: yesOpen Chemistry, 2010
Villano Rosaria   +3 more
doaj   +1 more source

Synthesis of a Stable Hydrophilic trans‐Cyclooctene Amino Acid Unlocks Fast Bioorthogonal Click Chemistry for the Generation of Antibody‐Drug Conjugates by Genetic Code Expansion

open access: yesAngewandte Chemie International Edition, EarlyView.
A novel trans‐cyclooctene (TCO) based noncanonical amino acid (ncAA) is reported, characterized by high hydrophilicity and remarkable stability to trans‐cis isomerization. Its incorporation via genetic code expansion into an antibody and subsequent conjugation resulted in a highly efficacious antibody‐drug conjugate (ADC).
Georgi R. Genov   +4 more
wiley   +1 more source

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