Results 101 to 110 of about 3,998 (209)
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, Volume 600, Issue 4, Page 418-438, February 2026.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Angewandte Chemie, Volume 138, Issue 5, 28 January 2026.A radical cascade process involving the activation of two aliphatic C–H bonds in a series of five elementary steps converts readily available terminal alkynes into functionalized cyclopentylmethyl arylsulfones. The methodology delivers flexible synthetic intermediates and was applied to the preparation of diquinanes and triquinanes possessing a rare ...
Lise Benoist +4 more
wiley +2 more sources
Advanced Materials, Volume 38, Issue 7, 2 February 2026.A systematic study of a series of porous organic cages with perfluorinated alkyl side‐chains of different lengths is presented. The structure‐property relationship of the various cages on gas sorption of highly potent greenhouse gases, such as perfluorocarbons (PFCs), sulfur hexafluoride (SF6), and nitrogen trifluoride (NF3) is investigated.
Ke Tian +8 more
wiley +1 more source
CuH‐Catalyzed Asymmetric Desymmetrization of Cyclobutenes via Stereodivergent Hydroamination
ChemistryEurope, Volume 4, Issue 2, February 2026.The CuH‐catalyzed stereodivergent hydroamination through asymmetric desymmetrization of cyclobutenes has been achieved, yielding a range of trisubstituted aminocyclobutanes with excellent results. A series of subsequent transformations, including the first asymmetric synthesis of two pharmaceutically active molecules, have been realized, and density ...
Xiang Lei +8 more
wiley +1 more source
Revista de Ciências Farmacêuticas Básica e Aplicada, 2010 O objetivo deste trabalho é avaliar a eficácia e a segurança da dose de 20 mg/dia de sibutramina em voluntários obesos, com IMC superior a 35, e compará-las com a dose de 10 mg/dia e à mudança de estilo de vida de pacientes com IMC inferior a 35 (a ...
Carlos Alberto Menezes +4 more
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Roles of Alp and Prt Regulons in the Response of Pseudomonas aeruginosa to UV‐C Light
Environmental Microbiology Reports, Volume 18, Issue 1, February 2026.Our results show that LexA‐regulated genes are the first to be induced after DNA damage, while autolysis functions controlled by the Alp system are the last. Death by UV is mediated primarily by Alp or Prt systems, depending on the Pseudomonas aeruginosa subline. ABSTRACT UV light is a well‐studied environmental DNA damaging agent.
Marina R. B. Fonseca +6 more
wiley +1 more source
A novel approach to target skin photodamage: Topical application of salt inducible kinase inhibitors
International Journal of Cosmetic Science, Volume 48, Issue 1, Page 1-15, February 2026.UV‐induced photodamage leads to increased DNA damage and elevated MMP levels, which degrade collagen and contribute to wrinkle formation. SLT‐001 and SLT‐008, novel cosmetic ingredients that target salt‐inducible kinase, help reverse this effect by enhancing DNA repair, reducing MMP expression and decreasing erythema, thereby mitigating photodamage ...
Inbal Rachmin +7 more
wiley +1 more source
Mechanochemistry of cyclobutanes
Science China ChemistryAbstractThe field of polymer mechanochemistry has been revolutionized by implementing force-responsive functional groups—mechanophores. The rational design of mechanophores enables the controlled use of force to achieve constructive molecular reactivity and material responses.
Roberto Obregon, Junpeng Wang
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International Journal of Cosmetic Science, Volume 48, Issue 1, Page 172-185, February 2026.The use of nanotechnology in sunscreens has increased, with various filters and organoclays tested for new intercalated formulations. As animal toxicity tests decrease, New Approach Methodologies are favoured. The S4 + OMC‐NC improved cell survival under SSL and showed antimutagenic properties, making it a promising candidate for safe photoprotection ...
Daniel Mabundu Kibwila +6 more
wiley +1 more source
Thiophenderivate als vielseitige Vorstufen für die Synthese von (Hetero)aromaten und Naturstoffen
Angewandte Chemie, Volume 138, Issue 5, 28 January 2026.Verborgen, aber leistungsstark: Thiophene und ihre gesättigten Analoga haben sich als vielseitige C4‐Bausteine erwiesen, die sich effektiv in der Naturstoffsynthese sowie beim Aufbau funktionalisierter (Hetero)aromaten einsetzen lassen. Dieser Minireview soll einen Überblick über Strategien zur Anwendung dieser schwefelhaltigen heterozyklischen ...
Anna Keimer, Franz‐Lucas Haut
wiley +1 more source