Results 151 to 160 of about 1,006 (183)

Discovery, biosynthesis, and bioactivities of peptidic natural products from marine sponges and sponge-associated bacteria.

Nat Prod Rep
Zhong W, Lin Z, Schmidt EW, Agarwal V.
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Synthetic Route to the GE3 Cyclodepsipeptide.

ChemInform, 2002
[reaction: see text] A reasonably efficient [2 + 2 + 2] fragment condensation strategy has been developed for assembling the cyclodepsipeptide sector of GE3 that involves 5-7. A Carpino HATU-mediated macrolactamization was used to close the 19-membered cyclodepsipeptide ring.
Karl J, Hale, Linos, Lazarides
openaire   +2 more sources

Cyclodepsipeptid‐Synthese durch Cyclooligomerisierung

Angewandte Chemie, 1977
Das Antibioticum Valinomycin ist ein cyclisches Depsipeptid der Formel (2), n=3. Durch Cyclooligomerisierung der linearen Untereinheiten vom Typ (1) in Toluol oder Diethylphosphit lassen sich alle Cyclodepsipeptide (2) darstellen.magnified ...
Manfred Rothe, Wolfgang Kreiß
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Filaricidal efficacy of anthelmintically active cyclodepsipeptides

International Journal for Parasitology, 2001
PF 1022A, a novel anthelmintically active cyclodepsipeptide, and Bay 44-4400, a semisynthetic derivative of PF 1022A were tested for filaricidal efficacy in Mastomys coucha infected with Litomosoides sigmodontis, Acanthocheilonema viteae and Brugia malayi. The parent compound PF 1022A showed limited anti-filarial efficacy in L.
H, Zahner, A, Taubert, A, Harder, G, von Samson-Himmelstjerna   +3 more
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Insecticidal Cyclodepsipeptides from Beauveria felina

Journal of Natural Products, 2011
A novel cyclodepsipeptide, iso-isariin B (1), and the known isaridin E (2) were isolated from the entomopathogenic fungus Beauveria felina. Their structures were elucidated using MS/MS fragmentation and extensive 2D-heteronuclear NMR. The X-ray structure of isaridin E was obtained, showing two potent intramolecular H bonds and a type-VI turn with the ...
Aude, Langenfeld, Alain, Blond, Sabelle, Gueye, Patrick, Herson, Bastien, Nay, Joëlle, Dupont, Soizic, Prado   +6 more
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Total Synthesis and Structural Determination of Cyclodepsipeptide Decatransin

Organic Letters, 2022
The structure determination of the 30-membered cyclodepsipeptide decatransin was demonstrated on the basis of total synthesis. Both (R)- and (S)-2-hydroxy-5-methylhexanoic acid derivatives were prepared via the Evans asymmetric alkylation. N-Alkyl-enriched peptide fragments were synthesized by the Cbz strategy in the solution phase without formation of
Kosuke Ohsawa, Sakiko Fukaya, Takayuki Doi   +2 more
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Solid-Phase Synthesis of a Cyclodepsipeptide: Cotransin

Organic Letters, 2008
The first solid-phase synthesis of cotransin--a cyclic depsipeptide having high pharmacological potential--was achieved, by a proper choice of coupling reagents and use of either TBAF or DBU for Fmoc removal to suppress the otherwise dominating, sequence-derived diketopiperazine formation.
Irene, Coin, Monika, Beerbaum, Peter, Schmieder, Michael, Bienert, Michael, Beyermann   +4 more
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Total Synthesis and Biosynthesis of Cyclodepsipeptide Cochinmicin I

Organic Letters, 2022
Phenylglycines are building blocks of many non-ribosomally synthesized peptides. The dihydroxyphenylglycine-containing cyclodepsipeptide cochinmicin I exhibits endothelin receptor antagonist activity. Therefore, it represents an interesting and synthetically challenging molecule because of the racemization-prone nature of dihydroxyphenylglycine.
Romina Schnegotzki, Vincent Wiebach, Marina Sánchez-Hidalgo, Marcel Tietzmann, Andreas B. zur Bonsen, Olga Genilloud, Roderich D. Süssmuth   +6 more
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Serine‐containing 10‐membered cyclodepsipeptides

International Journal of Peptide and Protein Research, 1993
As a part of a Research program aimed at studying synthesis and conformation of small ring peptides, the cyclization of diastereoisomeric N‐phenylacetyl‐seryl‐propyl‐proline tripeptides has been examined. Two 10‐ membered peptide lactones, and , have been isolated by treating the corresponding linear p‐nitrophenyl esters with DBU in dry benzene.
S. CERRINI, E. GAVUZZO, G. LUIS, F. PINNEN   +3 more
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Synthesis of Cyclodepsipeptides by Cyclooligomerization

Angewandte Chemie International Edition in English, 1977
The antibiotic valinomycin is a cyclic depsipeptide of formula (2), n=3. All cyclodepsipeptides (2) can be prepared by cyclooligomerization of the linear subunits of type (1) in toulene or diethyl phosphite. equation image
Manfred Rothe, Wolfgang Kreiss
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