Results 161 to 170 of about 1,006 (183)

Boholamide A, an APD-Class, Hypoxia-Selective Cyclodepsipeptide

Journal of Natural Products, 2020
Calcium homeostasis is implicated in some cancers, leading to the possibility that selective control of calcium might lead to new cancer drugs. On the basis of this idea, we designed an assay using a glioblastoma cell line and screened a collection of 1000 unique bacterial extracts.
Joshua P. Torres, Zhenjian Lin, David S. Fenton, Lee U. Leavitt, Changshan Niu, Pui-Ying Lam, Jose Miguel Robes, Randall T. Peterson, Gisela P. Concepcion, Margo G. Haygood, Baldomero M. Olivera, Eric W. Schmidt   +11 more
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Restricted Conformation Analogues of an Anthelmintic Cyclodepsipeptide

Journal of Medicinal Chemistry, 2003
Six analogues of the anthelmintic cyclodepsipeptide PF1022A were prepared, each containing a small ring fused to the macrocycle to restrict the number of conformations the larger ring can adopt. It was anticipated that such conformational changes could lead to enhanced biological activity and selectivity.
Fred E, Dutton, Byung H, Lee, Sandra S, Johnson, Eileen M, Coscarelli, Pil H, Lee   +4 more
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Chimeric Cyclodepsipeptides as Mimetics for the Anthelmintic PF1022A.

ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Hubert, Dyker, Achim, Harder, Jürgen, Scherkenbeck   +2 more
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Cyclols, cyclodepsipeptides, and N‐acyl‐diketopiperazines from linear precursors: Synthesis and crystal structure of 10‐membered cyclodepsipeptides

International Journal of Peptide and Protein Research, 1983
In order to investigate the relative formation tendency of different tautomeric ring systems (cyclols, cyclodepsipeptides and corresponding N ‐acyl‐diketopiperazines), two linear peptide precursors containing proline as C ‐terminal residue, have been synthesized and subjected to cyclizing conditions.
G, Zanotti, F, Pinnen, G, Lucente, S, Cerrini, E, Gavuzzo, F, Mazza   +5 more
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The monamycins, a new family of cyclodepsipeptide antibiotics

Experientia, 1970
Die Analyse von Monamycin, einem Antibiotika-Komplex, fuhrte zur Identifizierung der 15 Cyclohexadepsipeptidkomponenten. Fur Monamycin D1 wurde Strukturformel V abgeleitet.
K, Bevan, J S, Davies, M J, Hall, C H, Hassall, R B, Morton, D A, Phillips, Y, Ogihara, W A, Thomas   +7 more
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Mass spectrometry ofAlternaria mali toxins and related cyclodepsipeptides

Biological Mass Spectrometry, 1977
The structures of AM-toxins I, II and III, host specific phytotoxic metabolites of Alternaria mali, can be readily deduced from low and high resolution mass spectral data, since the amino acids and their sequences are demonstrated by this technique. Additionally, the general fragmentation of these compounds by electron impact is discussed by comparing ...
T, Ueno, T, Nakashima, M, Uemoto, H, Fukami, S N, Lee, N, Izumiya   +5 more
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[Hyphomycetes as organisms producing cyclodepsipeptides].

Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 2010
The review deals with cyclodepsipeptides produced by hyphomycetes. The cyclodepsipeptide compounds are prospective new agents for the treatment of diseases of the infectious and pathophysiologic nature.
M V, Bibikova, T O, Puzhevskaia, A V, Katlinskiĭ   +2 more
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A Novel Cyclodepsipeptide, HA23, from a Fusarium sp.

Organic Letters, 2002
[reaction: see text] HA 23, a novel cyclodepsipeptide (1) of mixed peptide-polyketide origins, was isolated from a fungal isolate of a Fusarium sp. The structure was determined from 1D and 2D NMR and mass spectral data.
Feng, YJ, Blunt, JW, Cole, ALJ, Munro, MHG   +3 more
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Synthesis of complex head-to-side-chain cyclodepsipeptides

Nature Protocols, 2016
Cyclodepsipeptides are cyclic peptides in which at least one amide link on the backbone is replaced with an ester link. These natural products present a high structural diversity that corresponds to a broad range of biological activities. Therefore, they are very promising pharmaceutical candidates.
Marta, Pelay-Gimeno, Fernando, Albericio, Judit, Tulla-Puche   +2 more
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PF1022A and Related Cyclodepsipeptides - A Novel Class of Anthelmintics

Current Topics in Medicinal Chemistry, 2002
Parasitic nematodes are a major cause of morbidity and mortality in man and also cause widespread loss of food production by infection of livestock. A milestone in the chemotherapy of nematode infections, especially in animals, was the discovery of the avermectins and milbemycins during the 1970s.
Jurgen, Scherkenbeck, Peter, Jeschke, Achim, Harder   +2 more
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