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Cyclodextrins, Surfactants and Their Inclusion Complexes [PDF]

Molecules
Herein, a brief overview of the cyclodextrin structure is provided, along with its most important derivatives. The difference between the water molecules in the outer hydration shell of cyclodextrin and those in its hydrophobic cavities is discussed. The
Ana Pilipović, Vesna Tepavčević, Dileep Kumar, Mihalj Poša   +3 more
doaj   +2 more sources

Cyclodextrin-based therapeutics delivery systems: A review of current clinical trials [PDF]

Current Research in Pharmacology and Drug Discovery
This review highlights the current status of cyclodextrin-based formulations tested in human participants, highlighting ongoing clinical research in this area.
Gjylije Hoti, Neha Bajwa, Fabrizio Caldera, Preet Amol Singh, Ibrahim Hussein, Claudio Cecone, Adrián Matencio, Rita Spagnolo, Monica Argenziano, Roberta Cavalli, Jitender Madan, Francesco Trotta   +11 more
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Testing the Protective Effects of Sulfobutylether-Βeta-Cyclodextrin (SBECD) and Sugammadex against Chlorpromazine-Induced Acute Toxicity in SH-SY5Y Cell Line and in NMRI Mice

Pharmaceutics, 2022
Chlorpromazine (CPZ) is an antipsychotic drug which can cause several adverse effects and drug poisoning. Recent studies demonstrated that CPZ forms highly stable complexes with certain cyclodextrins (CDs) such as sulfobutylether-β-CD (SBECD) and ...
Eszter Fliszár-Nyúl, Rita Csepregi, Gábor Benkovics, Lajos Szente, Miklós Poór   +4 more
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Streptococcus agalactiae amylomaltase offers insight into the transglycosylation mechanism and the molecular basis of thermostability among amylomaltases

Scientific Reports, 2021
Amylomaltase (AM) catalyzes transglycosylation of starch to form linear or cyclic oligosaccharides with potential applications in biotechnology and industry.
Suthipapun Tumhom, Pitchanan Nimpiboon, Kittikhun Wangkanont, Piamsook Pongsawasdi   +3 more
doaj   +1 more source

Cyclodextrin: A prospective nanocarrier for the delivery of antibacterial agents against bacteria that are resistant to antibiotics

Heliyon, 2023
Supramolecular chemistry introduces us to the macrocyclic host cyclodextrin, which has a hydrophobic cavity. The hydrophobic cavity has a higher affinity for hydrophobic guest molecules and forms host-guest complexation with non-covalent interaction ...
Pranoy Saha, Md Rajdoula Rafe
doaj   +1 more source

Weak complexation of 5-fluorouracil with β-cyclodextrin, carbonate, and dianhydride crosslinked β-cyclodextrin: in vitro and in silico studies

Research in Pharmaceutical Sciences, 2022
Background and purpose: Several pharmaceutical formulations were investigated to improve the solubility of 5-fluorouracil to enhance bioavailability and therapeutic efficacy. This study aimed to examine the potential use of cyclodextrin-based nanosponges
Hadeia Mashaqbeh, Rana Obaidat, Nizar A Al-Shar’i, Tamam El-Elimat, Soraya Alnabulsi   +4 more
doaj   +1 more source

The Biological Fate of Pharmaceutical Excipient β-Cyclodextrin: Pharmacokinetics, Tissue Distribution, Excretion, and Metabolism of β-Cyclodextrin in Rats

Molecules, 2022
β-cyclodextrin has a unique annular hollow ultrastructure that allows encapsulation of various poorly water-soluble drugs in the resulting cavity, thereby increasing drug stability.
Kunqian Mu, Kaiwen Jiang, Yue Wang, Zihan Zhao, Song Cang, Kaishun Bi, Qing Li, Ran Liu   +7 more
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Use of capillary electrophoresis as a method development tool for classical gel electrophoresis [PDF]

, 1998
Capillary electrophoresis (CE) was used to optimize the buffer pH, ionic strength and sulfated cyclodextrin concentrations for enantiomeric separation of piperoxan.
Gratz, Samuel R., Stalcup, Apryll, Sutton, Richard M. C.   +2 more
core   +1 more source

Fabrication of viable cyborg cells with cyclodextrin functionality [PDF]

, 2013
We describe two alternative methods for surface functionalisation of Saccharomyces cerevisiae cells with cyclodextrin molecules without affecting the cell viability.
Mathapa, Baghali G., Paunov, Vesselin N.
core   +1 more source

Cyclodextrin-Enabled Polymer Composites for Packaging †

Molecules, 2018
Cyclodextrin complexes of fragrances, antimicrobial agents, dyes, insecticides, UV-filters can be incorporated into polymers (packaging films, trays, containers) either to ensure the slow release or a homogeneous distribution of the complexed substances.
Lajos Szente, Éva Fenyvesi
doaj   +1 more source