Results 31 to 40 of about 75,442 (304)

Ionization States, Cellular Toxicity and Molecular Modeling Studies of Midazolam Complexed with Trimethyl-β-Cyclodextrin

Molecules, 2014
We investigated the ionization profiles for open-ring (OR) and closed-ring (CR) forms of midazolam and drug-binding modes with heptakis-(2,3,6-tri-O-methyl)-β-cyclodextrin (trimethyl-β-cyclodextrin; TRIMEB) using molecular modeling techniques and quantum
Sergey Shityakov, Tamás Sohajda, István Puskás, Norbert Roewer, Carola Förster, Jens-Albert Broscheit   +5 more
doaj   +1 more source

Homo- and hetero-difunctionalized β-cyclodextrins: Short direct synthesis in gram scale and analysis of regiochemistry

Beilstein Journal of Organic Chemistry, 2019
The regioselective difunctionalization of cyclodextrins (CDs) leading to derivatives amenable to further transformations is a daunting task due to challenging purification and unambiguous characterization of the obtained regioisomers with similar ...
Gábor Benkovics, Mihály Bálint, Éva Fenyvesi, Erzsébet Varga, Szabolcs Béni, Konstantina Yannakopoulou, Milo Malanga   +6 more
doaj   +1 more source

Investigation of molecular aggregation mechanism of glipizide/cyclodextrin complexation by combined experimental and molecular modeling approaches

Asian Journal of Pharmaceutical Sciences, 2019
Cyclodextrin complexation is a wise strategy to enhance aqueous solubility of water-insoluble drugs. However, the aggregation mechanism of drug-cyclodextrin complexes is still unclear.
Tianhe Huang, Qianqian Zhao, Yan Su, Defang Ouyang   +3 more
doaj   +1 more source

Novel β-cyclodextrin–eosin conjugates

Beilstein Journal of Organic Chemistry, 2017
Eosin B (EoB) and eosin Y (EoY), two xanthene dye derivatives with photosensitizing ability were prepared in high purity through an improved synthetic route.
Gábor Benkovics, Damien Afonso, András Darcsi, Szabolcs Béni, Sabrina Conoci, Éva Fenyvesi, Lajos Szente, Milo Malanga, Salvatore Sortino   +8 more
doaj   +1 more source

Cyclodextrins in Parkinson’s Disease [PDF]

Biomolecules, 2018
Parkinson’s disease is a movement disorder characterized by a progressive degeneration of dopaminergic neurons that has been object of study by the scientific community through the last decades. However, nowadays there is still no treatment to cure it, although there are drugs available, with limited efficacy, to relieve the symptoms or replenish the ...
Barros, Marisa C. F., Ribeiro, Ana C. F., Esteso, Miguel Á.   +2 more
openaire   +4 more sources

α-Cyclodextrin extracts diacylglycerol from insect high density lipoproteins

Journal of Lipid Research, 2000
α-Cyclodextrins are water-soluble cyclic hexamers of glucose units with hydrophobic cavities capable of solubilizing lipophiles. Incubating α-cyclodextrin with high density lipophorin from Manduca sexta or Bombyx mori resulted in a cloudy, turbid ...
Zeina E. Jouni, Jorge Zamora, Marcus Snyder, William R. Montfort, Andrzej Weichsel, Michael A. Wells   +5 more
doaj   +1 more source

The evolution of cyclodextrin glucanotransferase product specificity [PDF]

, 2009
Cyclodextrin glucanotransferases (CGTases) have attracted major interest from industry due to their unique capacity of forming large quantities of cyclic α-(1,4)-linked oligosaccharides (cyclodextrins) from starch.
Dijkhuizen, Lubbert; id_orcid, Leemhuis, Hans, Lubbert Dijkhuizen, Hans Leemhuis, Ronan M. Kelly, Dijkhuizen, Lubbert,, Dijkhuizen, Lubbert, Kelly, Ronan M.,, Leemhuis, Hans,, Kelly, Ronan M.   +9 more
core   +1 more source

Effects of RAMEA-complexed polyunsaturated fatty acids on the response of human dendritic cells to inflammatory signals

Beilstein Journal of Organic Chemistry, 2014
The n−3 fatty acids are not produced by mammals, although they are essential for hormone synthesis and maintenance of cell membrane structure and integrity.
Éva Rajnavölgyi, Renáta Laczik, Viktor Kun, Lajos Szente, Éva Fenyvesi   +4 more
doaj   +1 more source

Design, synthesis, and characterization of a series of novel β-cyclodextrin functional monomers

Journal of Chemical Research, 2022
In order to increase its solubility in water and improve β-cyclodextrin combination with guest molecules, chemical modification of β-cyclodextrin is a feasible and effective method.
Zhimin Liu, Zhigang Xu, Liping Ma
doaj   +1 more source

Identification of β -cyclodextrin inclusion complex by infrared spectroscopy

Фармацевтичний журнал, 2018
Fast and reliable identification of obtaining product is very important in the industrial technology of synthesis of pharmaceutical substances. Objective - to study inclusion complexes of β-cyclodextrin with α-bromizovalerian acid and β-cyclodextrin ...
I. O. Omelchenko, T. G. Yarnyh, I. B. Yanchuk, G. I. Borschevskiy   +3 more
doaj   +1 more source