Results 31 to 40 of about 46,196 (262)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Host–Guest Complex of β-Cyclodextrin and Disulfide Form of 4-Aminothiophenol

Applied Sciences, 2012
An inclusion complex of β-cyclodextrin and 4-aminothiophenol was assembled by hydrophobic interaction of the host (β-cyclodextrin) and guest (4-aminothiophenol).
Taylor A. Cappadona, Lee M. Daniels, Tasneem A. Siddiquee   +2 more
doaj   +1 more source

Cyclodextrins in Parkinson’s Disease [PDF]

Biomolecules, 2018
Parkinson’s disease is a movement disorder characterized by a progressive degeneration of dopaminergic neurons that has been object of study by the scientific community through the last decades. However, nowadays there is still no treatment to cure it, although there are drugs available, with limited efficacy, to relieve the symptoms or replenish the ...
Barros, Marisa C. F., Ribeiro, Ana C. F., Esteso, Miguel Á.   +2 more
openaire   +4 more sources

Molecular Adsorbing Host•Guest (MAHG) Crystals: A New Paradigm for Porous Materials?

Advanced Functional Materials, EarlyView.
Networking! Introduction of guest molecules in macrocycles before crystallization profoundly influences the material obtained in terms of structure and function. Beside simplicity and porous space improvement, this approach is endowed with a huge potential given the myriad of potential guest molecules that can be used to tune this burgeoning class of ...
Ingrid Suzana, Michel Giorgi, Anthony Kermagoret, Alexandre Martinez, David Bardelang   +4 more
wiley   +1 more source

Inclusion complexes and self-assembled cyclodextrin aggregates for increasing the solubility of benzimidazoles

Brazilian Journal of Pharmaceutical Sciences, 2019
Albendazole and fenbendazole are imidazole derivatives that exhibit broad spectrum activity against parasites, but the low solubility of these drugs considerably reduces their effectiveness. Complexation of albendazole and fenbendazole with cyclodextrins
Leticia Norma Carpentieri Rodrigues, Anna Carollina Moraes Tavares, Beatriz Tavares Ferreira, Adriana Karla Cardoso Amorim Reis, Luciana Morita Katiki   +4 more
doaj   +1 more source

Fusogenic RNA Nanomodules for Fusion‐Mediated and Multiplexed siRNA Delivery

Advanced Functional Materials, EarlyView.
A fusogenic lipid‐layered RNA nanomodules (L‐CRAMs) enable high‐capacity and long‐lasting siRNA delivery through membrane fusion. These nanomodules carry exceptionally large siRNA payloads, avoid conventional endosomal uptake, and release multiple functional siRNAs through Dicer‐mediated processing.
Sunghyun Moon, Iksoo Jang, Taehyeon Kim, Nayoung Yoon, Kyuha Yum, Jong Bum Lee   +5 more
wiley   +1 more source

Repetitive stability study of remdesivir/cyclodextrin complex on the international space station

Scientific Reports
Stability assessment of drugs in space is particularly important for future missions. In space there are multiple factors, such as the variability of the conditions (radiation, microgravity, vacuum etc.) that could affect the reliability and ...
György Dormán, Balázs Buchholcz, István Puskás, Pál Szabó, Erzsébet Varga, Lajos Szente, György M. Keserű, Ferenc Darvas   +7 more
doaj   +1 more source

Cyclodextrins Exert a Ligand-like Current Inhibitory Effect on the KV1.3 Ion Channel Independent of Membrane Cholesterol Extraction

Frontiers in Molecular Biosciences, 2021
Cyclodextrins (CDs) are cyclic oligosaccharides capable of forming water-soluble complexes with a variety of otherwise poorly soluble molecules including cholesterol and different drugs. Consistently, CDs are widely used in research and clinical practice
Tamas Kovacs, Tamas Sohajda, Lajos Szente, Peter Nagy, Gyorgy Panyi, Zoltan Varga, Florina Zakany   +6 more
doaj   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

?-cyclodextrin-MCM-41 silica as promising adsorbent for the trace amounts removal of aromatics from water

Хімія, фізика та технологія поверхні, 2016
Aromatic compounds are organic contaminants in aqueous streams of various industries. Even at low concentration, benzene and its derivatives are toxic agents.
I. M. Trofymchuk, N. V. Roik, L. A. Belyakova   +2 more
doaj   +1 more source