Results 51 to 60 of about 88,849 (292)
OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD
Advanced Science, EarlyView.This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li +11 more
wiley +1 more source
The Application of Microwave Heating Methods in Pharmaceutical Formulations [PDF]
This study investigated the potential application of formulating pharmaceutical products using microwave heating methods alongside associated analytical investigations.
Bedford, Susan
core +3 more sources
MoleculesCyclodextrins, commonly used as excipients in antifungal formulations to improve the physicochemical properties and availability of the host molecules, have not been systematically studied for their effects and bioactivity without a complex active ...
Rita Márton +5 more
doaj +1 more source
Cyclodextrin-Mediated Soft Cutting of Single-Walled Carbon Nanotubes
, 2016 Cyclodextrin-Mediated Soft Cutting of Single-Walled Carbon ...
Min-Feng Yu (1895527) +2 more
core +1 more source
Advanced Science, EarlyView.A mechanically robust, self‐healable, moisturizing, cryotolerant and adhesive GelMA hydrogel is developed by incorporating polyvinyl alcohol, acrylic acid, sodium tetraborate, and glycerol into GelMA matrix via a photoinitiated polymerization process. The hydrogel‐derived omni‐healable ionotronic pressure sensor can sensitively and consistently monitor
Zhikang Li +16 more
wiley +1 more source
Separation of folinic acid diastereomers in capillary electrophoresis using a new cationic β-cyclodextrin derivative. [PDF]
PLoS ONE, 2015 A method for the separation of folinic acid diastereomers by capillary electrophoresis in chiral separation media was developed. Aiming to achieve a good separation of the anionic analytes, a newly synthesized cationic β-cyclodextrin derivative, mono-6 ...
Jia Yu +5 more
doaj +1 more source
Advanced Science, EarlyView.A pathology‐informed engineering strategy rescues reconstituted HDL from inflammatory dysfunction in sepsis. By integrating a ceria nanozyme‐celastrol coordination complex, the platform preserves HDL structure and endotoxin handling, sustains hierarchical intracellular delivery, and enhances immunoregulation across pathological models, translating ...
Han Zhou +12 more
wiley +1 more source
Comparison of Inhibitory Effect of Curcumin Nanoparticles and Free Curcumin in Human Telomerase Reverse Transcriptase Gene Expression in Breast Cancer [PDF]
Advanced Pharmaceutical Bulletin, 2013 Purpose: Telomerase is expressed in most cancers, including breast cancer. Curcumin, a polyphenolic compound that obtained from the herb of Curcuma longa, has many anticancer effects. But, its effect is low due to poor water solubility.
Nosratollah Zarghami +2 more
doaj +1 more source
, 2016 The rate of hydrolysis of esters CF3(CF2)nCOOPh (1 (n = 1), 2 (n = 2), and 3 (n = 6)) was measured at pH 6.00 and at pH higher than 9.00 in the presence of β-cyclodextrin (β-CD). For compounds 1 and 2 the reaction rate decreases as the β-CD concentration
Rita H. de Rossi (2246269) +1 more
core +1 more source
An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2
Advanced Science, EarlyView.Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu +7 more
wiley +1 more source