Results 71 to 80 of about 88,849 (292)

Cyclodextrin-Modified Gold Nanospheres

, 2016
A new procedure for the modification of gold nanospheres (2−7 nm diameter) with thiolated cyclodextrin receptors is described. The resulting monolayer-protected nanoparticles behave as multisite hosts in aqueous media, engaging in host−guest interactions
Jian Liu (33711), Winston Ong (2411335), Esteban Román (2983746), Angel E. Kaifer (1489798), Matthew J. Lynn (2666584)   +4 more
core   +1 more source

An Engineered Supramolecular Pathway for Enhanced Electrochemiluminescence

Advanced Science, EarlyView.
A supramolecular electrochemiluminescent (ECL) system is presented in which cucurbit[7]uril (CB7) is covalently linked to [Ru(bpy)3]2+, forming a recognition‐responsive emitter. Host‒guest preorganization of tri‐n‐propylamine enables intramolecular ECL, boosting intensity by 162% compared to the standard system.
Maria Vittoria Balli, Madhurima Jana, Chiara Capolungo, Patrick Gruhs, Pierre Picchetti, Giovanni Valenti, Frank Biedermann, Luca Prodi   +7 more
wiley   +1 more source

HADHA K406 Lactylation Regulates Metabolic Reprogramming and Suppresses Immune Responses in Gastric Cancer

Advanced Science, EarlyView.
HADHA K406 lactylation fuels fatty acid β‐oxidation and HMGCR‐dependent cholesterol biosynthesis, fostering immunosuppressive MDSCs and exhausted CD8+ T cells in gastric cancer. Loss of this modification blocks cholesterol production, remodels the tumor microenvironment, and tumor growth is suppressed via combined inhibition of HMGCR and LDHA ...
Maoxiao Feng, Qinlian Jiao, Jiankang Zhu, Yidan Ren, Xiaoyu Teng, Xin Su, Zigan Li, Yuxuan Cai, Xiaoyan Liu, Yunshan Wang, Guangyong Zhang   +10 more
wiley   +1 more source

Cyclodextrin-Modified Gold Nanospheres. Host−Guest Interactions at Work to Control Colloidal Properties

, 2016
Cyclodextrin-Modified Gold Nanospheres.
Jian Liu (33711), Sandra Mendoza (3006924), Esteban Román (2983746), Angel E. Kaifer (1489798), Matthew J. Lynn (2666584), Renliang Xu (3006921)   +5 more
core   +1 more source

A Chiral Virus‐Like Nanoplatform That Broadly Mediates Antibiotic Delivery to the Brain for Bacterial Meningitis Therapy

Advanced Science, EarlyView.
Chiral virus‐mimicking mesoporous silica nanostructures (CVSNs) efficiently transport diverse antibiotics across the blood–brain barrier (BBB) into brain parenchyma and cerebrospinal fluid. By enhancing delivery to microglia and astrocytes, CVSNs improve antibiotic bioavailability and therapeutic efficacy against both Gram‐negative and Gram‐positive ...
Qianqian Xu, Xuting Zheng, Huinan Tong, Ying Liu, Xiaoxi Fan, Miao Xu, Ziyan Zhang, Li Zhang, Mingyan Liu, Ting Du, Heran Li, Guojun Liu   +11 more
wiley   +1 more source

Preparation, characterization and in vitro dissolution study of Nitrazepam: Cyclodextrin inclusion complex

Journal of Pharmacy and Bioallied Sciences, 2012
The objectives of this research were to prepare and characterize inclusion complexes of Nitrazepam with Hydroxypropyl-β-cyclodextrin (HPβCD) and Sulfobutyl ether β-cyclodextrin (SBEβCD) to study the effect of complexation on the dissolution rate of ...
J S Patel, R P Patel
doaj   +1 more source

Arhgef1 Deletion Disrupts Early Cortical Neurogenesis via PAK1 Overactivation and Causes Motor Dysfunction in Adulthood

Advanced Science, EarlyView.
ARHGEF1 plays a pivotal role in both embryonic cortical neurogenesis and adult motor function. During early development, it governs genesis of deep‐layer cortical neurons by negatively regulating RAC1/CDC42‐PAK1‐Cofilin signaling. In adulthood, ARHGEF1 is important for the maintenance of neuronal morphology and activity in the motor cortex, ensuring ...
Liuren Li, Xuanyue Ma, Zhenyu Ding, Bang Sun, Linglin Liu, Hei Matthew Yip, Wei Wang, Tianying Wu, Yuan Guo, Yinghui Peng, Shiqing Zhang, Jacque Pak Kan Ip, Li Zhang, Keshen Li, Lei Shi   +14 more
wiley   +1 more source

Chitosan-EDTA-cellulose functionalized with β-cyclodextrin as a pH-sensitive bio-based nanocarrier for curcumin drug delivery

Scientific Reports
In this work, chitosan/cellulose/β-cyclodextrin nanostructure was synthesized by cross-linking chitosan and cellulose with EDTA followed by bridging with ethylenediamine-β-cyclodextrin.
Negin Rostami, Mohammad G. Dekamin, Mohammad Reza Naimi-Jamal   +2 more
doaj   +1 more source

Cyclodextrin-Based Artificial Acyltransferase:  Substrate-Specific Catalytic Amidation of Carboxylic Acids in Aqueous Solvent

, 2016
Cyclodextrin-Based Artificial Acyltransferase:  Substrate-Specific Catalytic Amidation of Carboxylic Acids in Aqueous ...
Munetaka Kunishima (1490335), Keiji Terao (1378), Kazuma Yoshimura (2985573), Hiroshi Morigaki (2985576), Reiko Kawamata (2985579), Shohei Tani (2519794)   +5 more
core   +1 more source

Phase‐Programmed Microneedles Enable Sequential Hydrogen and Quercetin Release for Scar‐Reduced Regeneration of Burn Wounds

Advanced Science, EarlyView.
A phase‐programmed microneedle patch, comprising a poly (lactic‐co‐glycolic acid) (PLGA) shell and a sulfobutylether‐β‐cyclodextrin (SBECD) core, is designed for sequential hydrogen and quercetin release for scar‐reduced regeneration of burn wounds. ABSTRACT Burn wounds complicated by bacterial infection and fibrotic scarring remain a major clinical ...
Yongnian Zeng, Zhigang Chu, Huiyuan Yang, Wen Zhang, Peng Jiang, Jiapeng Lei, Siyu Zhang, Qiongfang Ruan, Shuhua Liu, Wei Li   +9 more
wiley   +1 more source