Results 91 to 100 of about 75,442 (304)

Construction of a MOF‐Based Snap‐Top Delivery Nanosystem for Powerful Dual‐Responsive Synergistic Colitis Treatment

Advanced Science, EarlyView.
A snap‐top delivery nanosystem based on an azobenzene metal–organic framework achieves targeted release of 6‐mercaptopurine via acid‐stable frameworks and hypoxia/pH dual‐responsive β‐cyclodextrin gates. This multifunctional platform integrates three synergistic mechanisms: precision drug delivery to inflammatory sites, intrinsic antioxidant properties
Xin Li, Miao Xu, Heran Li, Huan Jiang, Xin Wang, Lianjun Ma, Ying‐Wei Yang   +6 more
wiley   +1 more source

HM30181A, a potent P-glycoprotein inhibitor, potentiates the absorption and in vivo antitumor efficacy of paclitaxel in an orthotopic brain tumor model

Cancer Biology & Medicine, 2020
Objective: Delivery of chemotherapeutic drugs to the brain has remained a major obstacle in the treatment of glioma, owing to the presence of the blood-brain barrier and the activity of P-gp, which pumps its substrate back into the systemic circulation ...
Wu Zeng, Betty Yuen Kwan Law, Vincent Kam Wai Wong, Denise So Bik Chan, Simon Wing Fai Mok, Joyce Jia Ying Gao, Rebecca Ka Yan Ho, Xu Liang, Jia Hao Li, Ming Tsung Lee, Weng Li Yoon, Michael P Smolinski, Johnson Yiu Nam Lau, Christopher Wai Kei Lam, Manson Fok   +14 more
doaj   +1 more source

Synthesis of beta-cyclodextrin trimers for novel polymer networks

, 2011
Polymer hydrogels are formed by networks of polymer chains that are water-soluble. Polymer hydrogels have been extensively studied because of their potential applications in a broad range of fields.1 Our recent studies have generated a range of hydrogels
Nguyen, H.T., Guo, X., Easton, C., Wang, J., Lincoln, S., Pham, D.T.   +5 more
core  

Spontaneous Non‐Catalyzed Molecular Reactions and Interactions in the Human Body: Biomedical Implications

Advanced Science, EarlyView.
ABSTRACT The human body functions as a natural reactor for a vast network of chemical and biological reactions and physical interactions among small molecules, proteins, cells, and numerous other components. These reactions/interactions are essential for maintaining normal physiological functions.
Yuhao Cai, Chao Zhao
wiley   +1 more source

Study of the β-Cyclodextrin Imipramine Hydrochloride Inclusion Complex and Determination of its Stability Constant (K) by UV-Visible Spectroscopy

E-Journal of Chemistry, 2007
In this research, the interactions of imipramine hydrochloride drug with β- cyclodextrin and the stability constant (K) of the inclusion complex formed between them were investigated by using UV-visible spectroscopy.
Alamdar Ashnagar, Nahid Gharib Naseri, Bita Khanaki   +2 more
doaj   +1 more source

Degradação hidrolítica e fotoquímica da amoxicilina na presença de β-ciclodextrina

Eclética Química, 2018
This work has like purpose monitors the degradation of the drug amoxicillin in the presence and absence of β-cyclodextrin, through techniques spectroscopy.
Reinaldo A. Bariccatti, C. Silva, M. L. Souza, Cleber Antonio Lindino, Mauricio Ferreira da Rosa   +4 more
doaj   +1 more source

Complexation of Naphthylethanols with β-Cyclodextrin

, 2016
The complexation behavior of 1-naphthyl-1-ethanol (1-NpOH) and 2-naphthyl-1-ethanol (2-NpOH) with β-cyclodextrin (β-CD) was studied by employing several spectroscopic techniques. In the case of 1-NpOH, only a complex with 1:1 stoichiometry is formed with
T. C. Barros (3053640), C. Bohne (1300305), K. Stefaniak (3053637), J. F. Holzwarth (2705752)   +3 more
core   +1 more source

Bioorthogonal Fluorogenic Reporters for Noninvasive Imaging and Urinalysis of Immunotherapeutic Response in Renal Cell Carcinoma

Advanced Science, EarlyView.
This study reported renal‐clearable bio‐orthogonal near‐infrared fluorogenic probes (BGRs) that specifically imaging and urinalysis of granzyme B for dynamic evaluation of RCC immunotherapy. BGRs not only differentiate immunotherapeutic responses in orthotopic RCC mice, but also enable sensitive optical urinalysis of granzyme B in clinical specimens ...
Xingyue Yang, Baoshuai Liang, Liangmin Fu, Weiliang Deng, Yuyan Jiang, Weiping Xu, Jinwei Chen, Ya Zhou, Ke Wu, Jiaguo Huang   +9 more
wiley   +1 more source

Beta-cyclodextrin-based enzyme mimics.

, 2001
Beta-cyclodextrin-based enzyme ...
Jiaxin. Yu (7958642)
core  

The Role of Displacing Confined Solvent in the Conformational Equilibrium of β-Cyclodextrin

, 2019
This study investigates the role of hydration and its relationship to the conformational equilibrium of the host molecule β-cyclodextrin. Molecular dynamics simulations indicate that the unbound β-cyclodextrin exhibits two state behavior in explicit ...
Tom Kurtzman (6108167), Lauren Wickstrom (7013264), Emilio Gallicchio (7034335), Sheila Sarkar (7035219), Peng He (7034326)   +4 more
core   +1 more source