Results 21 to 30 of about 172,270 (336)

New synthetic strategies for xanthene-dye-appended cyclodextrins

Beilstein Journal of Organic Chemistry, 2016
Xanthene dyes can be appended to cyclodextrins via an ester or amide bridge in order to switch the fluorescence on or off. This is made possible through the formation of nonfluorescent lactones or lactams as the fluorophore can reversibly cyclize.
Milo Malanga, Andras Darcsi, Mihaly Balint, Gabor Benkovics, Tamas Sohajda, Szabolcs Beni   +5 more
doaj   +1 more source

Ionization States, Cellular Toxicity and Molecular Modeling Studies of Midazolam Complexed with Trimethyl-β-Cyclodextrin

Molecules, 2014
We investigated the ionization profiles for open-ring (OR) and closed-ring (CR) forms of midazolam and drug-binding modes with heptakis-(2,3,6-tri-O-methyl)-β-cyclodextrin (trimethyl-β-cyclodextrin; TRIMEB) using molecular modeling techniques and quantum
Sergey Shityakov, Tamás Sohajda, István Puskás, Norbert Roewer, Carola Förster, Jens-Albert Broscheit   +5 more
doaj   +1 more source

The influence of the preparation methods on the inclusion of model drugs in a β-cyclodextrin cavity [PDF]

, 2008
NOTICE: this is the author’s version of a work that was accepted for publication in European Journal of Pharmaceutics and Biopharmaceutics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting ...
Cassela, Charoenchaitrakool, Duan, Faucci, Fini, G. Feio, Gavira, Ghorab, Ghorab, H.M. Cabral Marques, Higgins, Higuchi, Hussein, J.F. Pinto, J.L. Figueirinhas, Jambhekar, Koester, Leite Pinto, Loftsson, Loftsson, Loftsson, Loftsson, Loftsson, Lu, Miller, Mura, Másson, Nerurkar, Oh, O’Brien, P.J. Salústio, Pose-Vilarnovo, Salvatierra, Scheneider, Silverstein, Sun, Tozuka, van Hees, Waleczek, Wu, Wulff   +40 more
core   +1 more source

Homo- and hetero-difunctionalized β-cyclodextrins: Short direct synthesis in gram scale and analysis of regiochemistry

Beilstein Journal of Organic Chemistry, 2019
The regioselective difunctionalization of cyclodextrins (CDs) leading to derivatives amenable to further transformations is a daunting task due to challenging purification and unambiguous characterization of the obtained regioisomers with similar ...
Gábor Benkovics, Mihály Bálint, Éva Fenyvesi, Erzsébet Varga, Szabolcs Béni, Konstantina Yannakopoulou, Milo Malanga   +6 more
doaj   +1 more source

Linear cyclodextrin polymer prodrugs as novel yherapeutics for Niemann-Pick type C1 disorder [PDF]

, 2018
Niemann-Pick Type C1 disorder (NPC) is a rare lysosomal storage disease characterized by the accumulation of cholesterol in lysosomes. NPC has no FDA approved treatments yet, however 2-hydroxypropyl-β-cyclodextrin (HPβCD) has shown efficacy for treating ...
Aditya Kulkarni, Alberto Macone, Atul Dolas, Jessica Dragotto, Maria Teresa Fiorenza, Paola Caporali, Ramesh Jayaraman, Sandeep Goyal, Soniya Johny   +8 more
core   +1 more source

Investigation of molecular aggregation mechanism of glipizide/cyclodextrin complexation by combined experimental and molecular modeling approaches

Asian Journal of Pharmaceutical Sciences, 2019
Cyclodextrin complexation is a wise strategy to enhance aqueous solubility of water-insoluble drugs. However, the aggregation mechanism of drug-cyclodextrin complexes is still unclear.
Tianhe Huang, Qianqian Zhao, Yan Su, Defang Ouyang   +3 more
doaj   +1 more source

Comparison of ibuprofen release from minitablets and capsules containing ibuprofen: β-Cyclodextrin complex [PDF]

, 2010
NOTICE: this is the author’s version of a work that was accepted for publication in European Journal of Pharmaceutics and Biopharmaceutics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting ...
Amidon, Berggren, Brewster, Bugay, Carr, Cirri, Custodio, Dhareshwar, Engers, Fages, Fell, Frömming, Gil, H.M. Cabral-Marques, Higashi, J.F. Pinto, Khamar, Martin Del Valle, Miller, Mura, Ng, P.C. Costa, P.J. Salústio, Reddy, Rupp, Salústio, Sapkal, Sebhatu, Talari, Wu, Yamamura, Yano   +31 more
core   +1 more source

Novel β-cyclodextrin–eosin conjugates

Beilstein Journal of Organic Chemistry, 2017
Eosin B (EoB) and eosin Y (EoY), two xanthene dye derivatives with photosensitizing ability were prepared in high purity through an improved synthetic route.
Gábor Benkovics, Damien Afonso, András Darcsi, Szabolcs Béni, Sabrina Conoci, Éva Fenyvesi, Lajos Szente, Milo Malanga, Salvatore Sortino   +8 more
doaj   +1 more source

Optimization of β-cyclodextrin-based extraction of antioxidant and anti-browning activities from thyme leaves by response surface methodology [PDF]

, 2018
Thyme (Thymus vulgaris) has been demonstrated to extend the shelf-life of food products, being also a potential source of bioactive compounds. The aim of this research was to optimize the ultrasound assisted extraction employing β-cyclodextrin aqueous ...
Buera, Maria del Pilar, dos Santos, Cristina, Favre, Leonardo Cristian, Lopez Fernandez, Maria Paula, Mazzobre, Maria Florencia   +4 more
core   +1 more source

α-Cyclodextrin extracts diacylglycerol from insect high density lipoproteins

Journal of Lipid Research, 2000
α-Cyclodextrins are water-soluble cyclic hexamers of glucose units with hydrophobic cavities capable of solubilizing lipophiles. Incubating α-cyclodextrin with high density lipophorin from Manduca sexta or Bombyx mori resulted in a cloudy, turbid ...
Zeina E. Jouni, Jorge Zamora, Marcus Snyder, William R. Montfort, Andrzej Weichsel, Michael A. Wells   +5 more
doaj   +1 more source