Results 31 to 40 of about 236,794 (382)

Design, Preparation and Evaluation of Supramolecular Complexes with Curcumin for Enhanced Cytotoxicity in Breast Cancer Cell Lines

Pharmaceutics, 2022
Curcumin is one of the most researched phytochemicals by pharmacologists and formulation scientists to unleash its potential therapeutic benefits and tackle inherent biopharmaceutic problems.
Hamdy Abdelkader, Adel Al Fatease, Zeinab Fathalla, Mai E. Shoman, Heba A. Abou-Taleb, Mohammed A. S. Abourehab   +5 more
doaj   +1 more source

Engineering of Cyclodextrin Product Specificity and pH Optima of the Thermostable Cyclodextrin Glycosyltransferase from Thermoanaerobacterium thermosulfurigenes EM1 [PDF]

, 1998
The product specificity and pH optimum of the thermostable cyclodextrin glycosyltransferase (CGTase) from Thermoanaerobacterium thermosulfurigenes EM1 was engineered using a combination of x-ray crystallography and site-directed mutagenesis.
Bauke W. Dijkstra, Bhat, Bradford, Brünger, Davies, Engh, Fujiwara, Haeckel, Harata, Jones, Joost C.M. Uitdehaag, Kabsch, Klein, Klein, Kleywegt, Knegtel, Knegtel, Koshland, Lamzin, Laskowski, Lawson, Lazzaroni, Lubbert Dijkhuizen, Monma, Nakamura, Nakamura, Norman, Pedersen, Penninga, Qian, Read, Reinetta M. Buitelaar, Richèle D. Wind, Sambrook, Sanger, Schmid, Starnes, Strokopytov, Strokopytov, Svensson, Takase, Takusagawa, Tronrud, Wind, Yanisch-Perron   +44 more
core   +2 more sources

Cyclodextrin Polymers and Cyclodextrin-Containing Polysaccharides for Water Remediation

, 2021
Chemical pollution of water has raised great concerns among citizens, lawmakers, and nearly all manufacturing industries. As the legislation addressing liquid effluents becomes more stringent, water companies are increasingly scrutinized for their ...
Tânia F Cova, D. Murtinho, R. Aguado, A. Pais, A. Valente   +4 more
semanticscholar   +1 more source

Pharmacokinetics and tumor dynamics of the nanoparticle IT-101 from PET imaging and tumor histological measurements [PDF]

, 2009
IT-101, a cyclodextrin polymer-based nanoparticle containing camptothecin, is in clinical development for the treatment of cancer. Multiorgan pharmacokinetics and accumulation in tumor tissue of IT-101 is investigated by using PET.
Alley, B. C. Mack, Braet, C. A. Alabi, C. H. J. Choi, Carter, Cheng, Cheng, Davis, Davis, Dreher, Drummond, Hashizume, Heidel, Hobbs, I. J. Hildebrandt, J. Czernin, J. Hwang, Kirpotin, Loening, M. E. Davis, Matsumura, Moore, O'Connor, Reddy, Riches, Schluep, Schluep, Schluep, T. Schluep, Tabata, Tirona, Torchilin, Yuan   +33 more
core   +3 more sources

History of Cyclodextrin Nanosponges

Polymers, 2020
Nowadays, research in the field of nanotechnology and nanomedicine has become increasingly predominant, focusing on the manipulation and development of materials on a nanometer scale.
Ilona Krabicová, S. L. Appleton, M. Tannous, Gjylije Hoti, F. Caldera, Alberto Rubin Pedrazzo, Claudio Cecone, R. Cavalli, F. Trotta   +8 more
semanticscholar   +1 more source

Linear cyclodextrin polymer prodrugs as novel yherapeutics for Niemann-Pick type C1 disorder [PDF]

, 2018
Niemann-Pick Type C1 disorder (NPC) is a rare lysosomal storage disease characterized by the accumulation of cholesterol in lysosomes. NPC has no FDA approved treatments yet, however 2-hydroxypropyl-β-cyclodextrin (HPβCD) has shown efficacy for treating ...
Aditya Kulkarni, Alberto Macone, Atul Dolas, Jessica Dragotto, Maria Teresa Fiorenza, Paola Caporali, Ramesh Jayaraman, Sandeep Goyal, Soniya Johny   +8 more
core   +1 more source

New synthetic strategies for xanthene-dye-appended cyclodextrins

Beilstein Journal of Organic Chemistry, 2016
Xanthene dyes can be appended to cyclodextrins via an ester or amide bridge in order to switch the fluorescence on or off. This is made possible through the formation of nonfluorescent lactones or lactams as the fluorophore can reversibly cyclize.
Milo Malanga, Andras Darcsi, Mihaly Balint, Gabor Benkovics, Tamas Sohajda, Szabolcs Beni   +5 more
doaj   +1 more source

Ionization States, Cellular Toxicity and Molecular Modeling Studies of Midazolam Complexed with Trimethyl-β-Cyclodextrin

Molecules, 2014
We investigated the ionization profiles for open-ring (OR) and closed-ring (CR) forms of midazolam and drug-binding modes with heptakis-(2,3,6-tri-O-methyl)-β-cyclodextrin (trimethyl-β-cyclodextrin; TRIMEB) using molecular modeling techniques and quantum
Sergey Shityakov, Tamás Sohajda, István Puskás, Norbert Roewer, Carola Förster, Jens-Albert Broscheit   +5 more
doaj   +1 more source

Homo- and hetero-difunctionalized β-cyclodextrins: Short direct synthesis in gram scale and analysis of regiochemistry

Beilstein Journal of Organic Chemistry, 2019
The regioselective difunctionalization of cyclodextrins (CDs) leading to derivatives amenable to further transformations is a daunting task due to challenging purification and unambiguous characterization of the obtained regioisomers with similar ...
Gábor Benkovics, Mihály Bálint, Éva Fenyvesi, Erzsébet Varga, Szabolcs Béni, Konstantina Yannakopoulou, Milo Malanga   +6 more
doaj   +1 more source

Investigation of molecular aggregation mechanism of glipizide/cyclodextrin complexation by combined experimental and molecular modeling approaches

Asian Journal of Pharmaceutical Sciences, 2019
Cyclodextrin complexation is a wise strategy to enhance aqueous solubility of water-insoluble drugs. However, the aggregation mechanism of drug-cyclodextrin complexes is still unclear.
Tianhe Huang, Qianqian Zhao, Yan Su, Defang Ouyang   +3 more
doaj   +1 more source