Results 1 to 10 of about 231,004 (334)

Association between serum prostacyclin and cerebrovascular reactivity in healthy young and older adults

Experimental Physiology, 2023
Platelet activation may contribute to age‐related cerebrovascular dysfunction by interacting with the endothelial cells that regulate the response to vasodilatory stimuli.
Adam T. Corkery, Kathleen B. Miller, Carissa A. Loeper, Laura H. Tetri, Andrew G. Pearson, Nicole A. Loggie, Anna J. Howery, Marlowe W. Eldridge, Jill N. Barnes   +8 more
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Investigation of the «Structure – analgesic activity» Relationship Using Molecular Docking for Cyclooxygenases 1 and 2 in the Series 5-N-arylaminocarbonyl-6-(get)aryl-4-methyl-1,2,3,6-tetrahydropyrimidine-2-thiones

Разработка и регистрация лекарственных средств, 2023
Introduction. Molecular modeling methods are very popular in the scientific community at the present time. The value of the pharmacological action depends on the affinity of the substance to the biological target.
N. A. Buzmakova, K. V. Аndryukov, T. M. Zamaraeva, I. P. Rudakova, K. V. Podchezertseva, A. S. Goman, E. V. Avdeeva, N. V. Slepova, N. V. Dozmorova   +8 more
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Beneficial Modulation of Lipid Mediator Biosynthesis in Innate Immune Cells by Antirheumatic Tripterygium wilfordii Glycosides

Biomolecules, 2021
Tripterygium wilfordii glycosides (TWG) is a traditional Chinese medicine with effectiveness against rheumatoid arthritis (RA), supported by numerous clinical trials.
Kehong Zhang, Simona Pace, Paul M. Jordan, Lukas K. Peltner, Alexander Weber, Dagmar Fischer, Robert K. Hofstetter, Xinchun Chen, Oliver Werz   +8 more
doaj   +1 more source

Pharmacological hypotheses: Is acetaminophen selective in its cyclooxygenase inhibition?

Pharmacology Research & Perspectives, 2021
The precise mechanistic action of acetaminophen (ACT; paracetamol) remains debated. ACT’s analgesic and antipyretic actions are attributed to cyclooxygenase (COX) inhibition preventing prostaglandin (PG) synthesis.
Christopher J. Esh, Bryna C. R. Chrismas, Alexis R. Mauger, Lee Taylor   +3 more
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Cyclooxygenase-2 inhibitors. 1,5-diarylpyrrol-3-acetic esters with enhanced inhibitory activity toward cyclooxygenase-2 and improved cyclooxygenase-2/cyclooxygenase-1 selectivity. [PDF]

, 2007
he important role of cyclooxygenase-2 (COX-2) in the pathogenesis of inflammation and side effect limitations of current COX-2 inhibitor drugs illustrates a need for the design of new compounds based on alternative structural templates.
ANZELLOTTI P, ANZINI M., BIAVA M, BOTTA M, CAPPELLI A, FORLI S, GHELARDINI C, MAKOVEC F, MANETTI, F, PATRIGNANI P, PERGOLA, CARLO, POCE G, PORRETTA GC, ROSSI, ANTONIETTA, ROVINI M, SAUTEBIN, LIDIA, SUPINO S, VIVOLI E   +17 more
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Nimesulide limits kainate-induced oxidative damage in the rat hippocampus [PDF]

, 2000
Kainate induces a marked expression of cyclooxygenase-2 after its systemic administration. Because cyclooxygenase-2 activity is associated to the production of reactive oxygen species, we investigated the effects of nimesulide, a selective cyclooxygenase-
Ajamieh, Hussam, Candelario-Jalil, Eduardo, Leon, Olga S., Martinez, Gregorio, Sam, Susana   +4 more
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Lipoxygenase and cyclooxygenase metabolism: new insights in treatment and chemoprevention of pancreatic cancer

Molecular Cancer, 2003
The essential fatty acids, linoleic acid and arachidonic acid play an important role in pancreatic cancer development and progression. These fatty acids are metabolized to eicosanoids by cyclooxygenases and lipoxygenases.
Adrian Thomas E, Hennig Rene, Ding Xian-Zhong   +2 more
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Exploration of collagenase, cyclooxigenases, angiogenesis and free radical processes as the putative pharmacological targets of Arum maculatum L.

Biotechnology & Biotechnological Equipment, 2020
In line with the well-established ethnobotanical use of Arum maculatum for the treatment of hemorrhoidal disease, we sought to determine the activities of 30% or 70% ethanol extracts of the plant tubers in an array of pharmacological and biochemical ...
Vladimir Kochmarov, Lyubomir Marinov, Ekaterina Kozuharova, Nadya Hristova-Avakumova, Vera Hadjimitova, Trayko Traykov, Sefedin Biljali, Nexhibe Nuhiu, Niko Benbassat, Georgi Momekov   +9 more
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Ascorbic acid enhances the inhibitory effect of aspirin on neuronal cyclooxygenase-2-mediated prostaglandin E2 production. [PDF]

, 2006
Inhibition of neuronal cyclooxygenase-2 (COX-2) and hence prostaglandin E2 (PGE2) synthesis by non-steroidal anti-inflammatory drugs has been suggested to protect neuronal cells in a variety of pathophysiological situations including Alzheimer's disease ...
Akundi, Ravi S., Appel, Kurt, Bhatia, Harsharan S., Candelario-Jalil, Eduardo, Fiebich, Bernd L., Hull, Michael, Lieb, Klaus, Munoz, Eduardo   +7 more
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Vascular changes after cardiopulmonary bypass and ischemic cardiac arrest: roles of nitric oxide synthase and cyclooxygenase

Brazilian Journal of Medical and Biological Research, 1999
Cardiac surgery involving ischemic arrest and extracorporeal circulation is often associated with alterations in vascular reactivity and permeability due to changes in the expression and activity of isoforms of nitric oxide synthase and cyclooxygenase ...
F.W. Sellke
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