Results 201 to 210 of about 106,132 (242)
Cyclooxygenase-2 expression in advanced oral squamous cell carcinoma: a biomarker of poor prognosis. [PDF]
BMC Oral HealthChen X, Ouyang Q, Fan R, Luo L, Mai H.
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High-dose folic acid supplement is associated with increased cardiovascular risk in rheumatoid arthritis patients on methotrexate. [PDF]
Ther Adv Musculoskelet DisMeng H +6 more
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Impact of CD68, CD4, TNF-α, and COX-2 expression on disease-specific survival in Brazilian patients with OSCC. [PDF]
Braz Oral ResAquino SN +8 more
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Current Protocols in Pharmacology, 1998
AbstractCyclooxygenase (COX, also known as prostaglandin H2 synthase, PGH2) is one of the most significant enzymes in pharmacology since COX inhibition is the mechanism of action of most nonsteroidal anti‐inflammatory drugs (NSAIDs). There are two forms: COX‐1 is a constitutive form of the enzyme that has been linked to the production of ...
J K, Gierse, C M, Koboldt
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AbstractCyclooxygenase (COX, also known as prostaglandin H2 synthase, PGH2) is one of the most significant enzymes in pharmacology since COX inhibition is the mechanism of action of most nonsteroidal anti‐inflammatory drugs (NSAIDs). There are two forms: COX‐1 is a constitutive form of the enzyme that has been linked to the production of ...
J K, Gierse, C M, Koboldt
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Cyclooxygenase‐independent actions of cyclooxygenase inhibitors
The FASEB Journal, 2001Several studies have demonstrated unequivocally that certain nonsteroidal anti‐inflammatory drugs (NSAIDs) such as sodium salicylate, sulindac, ibuprofen, and flurbiprofen cause anti‐inflammatory and antiproliferative effects independent of cyclooxy‐genase activity and prostaglandin synthesis inhibition.
I, Tegeder +2 more
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Current Opinion in Chemical Biology, 2000
Several advances have occurred in the past year in our understanding of cyclooxygenase catalysis. The role of specific heme oxidation states in the formation of catalytically competent tyrosyl radicals has been defined; the identity of physiological hydroperoxide activators has been established; and the participation of individual amino acids in ...
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Several advances have occurred in the past year in our understanding of cyclooxygenase catalysis. The role of specific heme oxidation states in the formation of catalytically competent tyrosyl radicals has been defined; the identity of physiological hydroperoxide activators has been established; and the participation of individual amino acids in ...
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Pharmacogenomics of Cyclooxygenases
Pharmacogenomics, 2015Cyclooxygenases (COX-1 and COX-2) are key enzymes in several physiopathological processes. Many adverse drugs reactions to NSAIDs are attributable to COX-inhibition. The genes coding for these enzymes (PTGS1 and PTGS2) are highly variable, and variations in these genes may underlie the risk of developing, or the clinical evolution of, several diseases ...
José A G, Agúndez +3 more
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Current Opinion in Internal Medicine, 2006
The purpose of this review is to summarize new information regarding the use of selective inhibitors of the cyclooxygenase-2 enzyme, emphasizing recent developments regarding cardiovascular risk.Selective cyclooxygenase-2 inhibitors are as effective as nonselective nonsteroidal antiinflammatory drugs in relieving pain and inflammation but are ...
Christopher J, Hawkey, Paul J, Fortun
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The purpose of this review is to summarize new information regarding the use of selective inhibitors of the cyclooxygenase-2 enzyme, emphasizing recent developments regarding cardiovascular risk.Selective cyclooxygenase-2 inhibitors are as effective as nonselective nonsteroidal antiinflammatory drugs in relieving pain and inflammation but are ...
Christopher J, Hawkey, Paul J, Fortun
openaire +2 more sources