Results 211 to 220 of about 106,132 (242)

Differential effects of inhibitors of cyclooxygenase (cyclooxygenase 1 and cyclooxygenase 2) in acute inflammation

European Journal of Pharmacology, 1998
The anti-inflammatory activity of drugs more selective for cyclooxgenase isoform inhibition (cyclooxygenase 1, cyclooxygenase 2), were compared in rat carrageenin-induced pleurisy. Suppression of inflammation by cyclooxygenase 2-selective inhibitors, NS-398 (N-[-2-cyclohexyloxy]-4-nitrophenyl methanesulphonamide) and nimesulide (4-nitro-2-phenoxy ...
D W, Gilroy, A, Tomlinson, D A, Willoughby   +2 more
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Cyclooxygenase and Colon Cancer

Prostaglandins & Other Lipid Mediators, 2001
There is considerable interest in the involvement of cyclooxygenase-2 (COX-2) in colon carcinogenesis and its progression, because nonsteroidal anti-inflammatory drugs (NSAIDs) reduce mortality from colon cancer and COX-2 is one of the known targets of NSAIDs. COX-2 mRNA and protein levels are increased in colon cancer tissues from patients and in some
Naoki, Kawai, Masahiko, Tsujii, Shingo, Tsuji   +2 more
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Cyclooxygenase-2 inhibitors

2001
Publisher Summary This chapter deals with aspects of the discovery and development of Cyclooxygenase-2 (Cox-2) inhibitors, which, in the case of rofecoxib, resulted from efforts that were initiated in July of 1992 and culminated in the launch of the drug in the United States in June of 1999. Nonsteroidal antiinflammatory drugs (NSAIDs) have long been
A S, Nies, M J, Gresser
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[Cyclooxygenases].

Presse medicale (Paris, France : 1983), 2001
TWO ISOFORMS: There are two isoforms of cyclooxygenase (COX) with similar structure and metabolic activity. COX-1 is a constitutional enzyme. COX-2 is an inductible form. CYCLOOXYGENASE-1: COX-1 is present in most tissues, particularly in the kidney, the digestive tract mucosa, platelets, brain, liver and spleen.
P, Eschwège, V, de Ledinghen, T, Camilli, S, Kulkarni, G, Dalbagni, S, Droupy, A, Jardin, G, Benoît, B B, Weksler   +8 more
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Perspectives on the Cyclooxygenase-2/ Cyclooxygenase-1 Hypothesis

JCR: Journal of Clinical Rheumatology, 1998
The introduction of the cyclooxygenase (COX) hypothesis to explain both the therapeutic effects and the toxicity of nonsteroidal anti-inflammatory drugs (NSAIDs) has provided direction for the development of preferential and highly selective COX-2 inhibitors, which retain efficacy against inflammation with reduced risk of toxicity. However, the complex
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Cloning and Expression of Cyclooxygenase-1 and Cyclooxygenase-2

2010
Cyclooxygenase (COX) enzymes play important roles in normal physiology and during inflammation of various cells and tissues. In order to help understand the functions of these enzymes, their genes can be cloned to facilitate the production of the proteins in recombinant form.
Nicholas R, Staten, Beverly A, Reitz
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Prostaglandin cyclooxygenase

Progress in Lipid Research, 1981
F A, Kuehl, R W, Egan, J L, Humes
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Cyclooxygenase-2 Biology

Current Pharmaceutical Design, 2003
In mammalian cells, eicosanoid biosynthesis is usually initiated by the activation of phospholipase A(2) and the release of arachidonic acid from membrane phospholipids in response to the interaction of a stimulus with a receptor on the cell surface. Arachidonic acid is subsequently transformed by the enzyme cyclooxygenase (COX) to prostaglandins (PGs)
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Cyclooxygenases

2006
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Cyclooxygenase

Cyclooxygenases are iron-containing enzymes involved in the oxidation of arachidonic acid and other lipids. They carry out the starting step of the synthesis of prostanoids, which are important mediators of several physiological and pathological processes, among which are inflammation, blood clotting, and cancer.
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