Results 221 to 230 of about 231,004 (334)

Efficacy and Safety of Human Skin Microbiome-Derived Strains as Topical Treatment for Acne: An In Vitro and In Vivo Study. [PDF]

J Korean Med Sci
Lee SG, Lee JH, Baek Y, Chu J, Kim KH, Ham S, Shin CH, Lee YI.   +7 more
europepmc   +1 more source

2D interaction of compound 6e (left) and indomethacin drug (right) within the active site of cyclooxygenase-1 (COX-1) (PDB ID: 1EQG).

Yasser Hussein Issa Mohammed (17140711), Ahmed Hassen Shntaif (22320292), Saad Alghamdi (362506), Ahd A. Mansour (21660692), Naeem F. Qusty (15416890), Azhar S. Sindi (13259916), Ahmad O. Babalghith (15279713), Ghazi A. Bamagous (22320295), Eman Adnan Abu-Seer (22320298)   +8 more
openalex   +1 more source

Synthesis of novel pyrazole–thiadiazole hybrid as potential potent and selective cyclooxygenase-2 (COX-2) inhibitors

, 2014
Shankar G. Alegaon, Mita B. Hirpara, K. R. Alagawadi, Kirankumar Hullatti, Kamlesh Kashniyal   +4 more
openalex   +1 more source

Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair [PDF]

, 2002
Xinping Zhang, Edward M. Schwarz, Donald A. Young, J. Edward Puzas, Randy N. Rosier, Regis J. O’Keefe   +5 more
openalex   +1 more source

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Region-Specific Roles of TGF-β2 and Angiotensin II in Fibrotic and Inflammatory Remodeling of the Optic Nerve Head. [PDF]

Cells
Oh SE, Kim JH, Park SE, Park CK, Park HL.   +4 more
europepmc   +1 more source

PyPLIF-ASSISTED REDOCKING INDOMETHACIN-(R)-ALPHA-ETHYL-ETHANOLAMIDE INTO CYCLOOXYGENASE-1

, 2013
Muhammad Radifar, Nunung Yuniarti, Enade Perdana Istyastono   +2 more
openalex   +1 more source

Immune Predictors of Radiotherapy Outcomes in Cervical Cancer

Advanced Science, EarlyView.
This study reveals dynamic immune remodeling in cervical cancer following radiotherapy. Single‐cell analysis identifies the C3/C3AR1 axis as a central mediator of epithelial–myeloid crosstalk, whose inhibition reduces treatment efficacy in mice. Guided by these insights, the eight‐feature machine‐learning model: Cervical Cancer Radiotherapy Immune ...
Linghao Wang, Jie Zhu, Zequn Ding, Zhiyuan Xie, Xingchen Liu, Feihong Zhang, Xiaojun Liu, Yan Zhang, Haiyan Chen   +8 more
wiley   +1 more source

Effects of perioperative dexmedetomidine on renal vascular function and renovascular histopathology in ovine cardiopulmonary bypass. [PDF]

Intensive Care Med Exp
Betrie AH, Jufar AH, Evans RG, Cochrane AD, Marino B, Birchall I, Hood SG, McCall PR, Ayton S, Miles LF, May CN, Lankadeva YR.   +11 more
europepmc   +1 more source

Phenylacetic acid regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: Evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity

, 2009
Gang Yu, Morshed Alam Chowdhury, Khaled R.A. Abdellatif, Ying Dong, Praveen P. N. Rao, Dipankar Das, Carlos Velázquez, Mavanur R. Suresh, Edward E. Knaus   +8 more
openalex   +1 more source