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Current Pharmaceutical Design, 2003
In mammalian cells, eicosanoid biosynthesis is usually initiated by the activation of phospholipase A(2) and the release of arachidonic acid from membrane phospholipids in response to the interaction of a stimulus with a receptor on the cell surface. Arachidonic acid is subsequently transformed by the enzyme cyclooxygenase (COX) to prostaglandins (PGs)
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In mammalian cells, eicosanoid biosynthesis is usually initiated by the activation of phospholipase A(2) and the release of arachidonic acid from membrane phospholipids in response to the interaction of a stimulus with a receptor on the cell surface. Arachidonic acid is subsequently transformed by the enzyme cyclooxygenase (COX) to prostaglandins (PGs)
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Cloning and Expression of Cyclooxygenase-1 and Cyclooxygenase-2
2010Cyclooxygenase (COX) enzymes play important roles in normal physiology and during inflammation of various cells and tissues. In order to help understand the functions of these enzymes, their genes can be cloned to facilitate the production of the proteins in recombinant form.
Beverly A. Reitz, Nicholas R. Staten
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Cyclooxygenase-2 and inflammation in atherosclerosis
Current Opinion in Pharmacology, 2004By regulating the production of eicosanoids, cyclooxygenase (COX) modulates processes contributing to atherosclerosis and thrombosis, including platelet aggregation and the local inflammatory response. COX-2, a key mediator of inflammation, is upregulated in activated monocyte/macrophages, suggesting that COX-2 inhibition might reduce atherogenesis ...
MacRae F. Linton, Sergio Fazio
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Lung cancer and cyclooxygenase-2
The Annals of Thoracic Surgery, 2003Lung cancer is by far the leading cause of cancer-related death. Overall survival is poor and has not improved substantially over the last half century. It is clear that new approaches are needed and these should include prevention, screening for early detection, and novel treatments based on our understanding of the molecular biology of this disease ...
Ross M. Bremner +4 more
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Cyclooxygenase-2 and prostate carcinogenesis
Cancer Letters, 2003In recent years a dramatic surge has occurred on studies defining to the role of cyclooxygenase (COX)-2 in causation and prevention of cancer. Prostaglandin (PG) endoperoxidase synthase also commonly referred to as COX is a key enzyme involved in the conversion of arachidonic acid to PGs and other eicosanoids.
T. Hussain, Hasan Mukhtar, Sanjay Gupta
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Perspectives on the Cyclooxygenase-2/ Cyclooxygenase-1 Hypothesis
JCR: Journal of Clinical Rheumatology, 1998The introduction of the cyclooxygenase (COX) hypothesis to explain both the therapeutic effects and the toxicity of nonsteroidal anti-inflammatory drugs (NSAIDs) has provided direction for the development of preferential and highly selective COX-2 inhibitors, which retain efficacy against inflammation with reduced risk of toxicity. However, the complex
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Cyclooxygenase-2 and Gastrointestinal Cancer
The Cancer Journal, 2004The cyclooxygenase (COX) enzymes (COX-1 and COX-2) are key enzymes of prostaglandin (PG) biosynthesis. Nonselective non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the enzymatic activity of both COX-1 and COX-2. Selective COX-2 inhibitors have been developed that appear to have 50% less gastrointestinal toxicity than traditional nonselective ...
Raymond N. DuBois, Jason R. Mann
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Cyclooxygenase-2 Expression in Chondrosarcoma
Oncology, 2004<i>Objective:</i> In recent years it has become evident that tissue cyclooxygenase-2 (COX-2) may play a role in carcinogenesis and tumor malignancy. There is now a mounting body of information that strongly implies that COX-2 inhibitors may be of some value in the management of patients with carcinomas, and most recently several similar ...
Marianne Wright +4 more
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THE ROLE OF CYCLOOXYGENASE-2 IN INFLAMMATION
American Journal of Therapeutics, 1995Prostaglandins (PGs) can be synthetized via two isoforms of cyclooxygenase (COX). COX-1 is constitutively expressed in normal tissues, and its activity represent the normal physiological output of PGs. In inflammatory states, the newly discovered COX-2 is rapidly induced, and its activity accounts for the large amounts of PGs seen in inflammation.
Daniela Salvemini +6 more
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Cyclooxygenase‐2 and gastric carcinogenesis
APMIS, 2003Epidemiological studies have shown that the use of nonsteroid anti‐inflammatory drugs (NSAIDs) is associated with reduced risk of gastric cancer. The best‐known target of NSAIDs is the cyclooxygenase (Cox) enzyme. Two Cox genes have been cloned, of which Cox‐2 has been connected with gastric carcinogenesis.
J. Jan B. van Lanschot +9 more
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