Results 311 to 320 of about 216,666 (331)

Cyclooxygenase-2 Inhibitors

Current Pharmaceutical Design, 1995
Prostaglandins are synthesized by the enzyme cyclooxygenase (COX), which is the target for nonsteroidal anti-inflammatory drugs (NSAIDs). Recently a second form of COX was discovered (COX-2) that is induced by inflammatory stimuli. The identification of an inducible form of COX led to the hypothesis that COX-2 is responsible for inflammatory ...
David B. Reitz, Peter C. Isakson
openaire   +1 more source

Perspectives on the Cyclooxygenase-2/ Cyclooxygenase-1 Hypothesis

JCR: Journal of Clinical Rheumatology, 1998
The introduction of the cyclooxygenase (COX) hypothesis to explain both the therapeutic effects and the toxicity of nonsteroidal anti-inflammatory drugs (NSAIDs) has provided direction for the development of preferential and highly selective COX-2 inhibitors, which retain efficacy against inflammation with reduced risk of toxicity. However, the complex
openaire   +2 more sources

Cyclooxygenase-2 and Gastric Cancer

Cancer and Metastasis Reviews, 2011
Gastric cancer remains a leading cause of cancer-related deaths worldwide, although its incidence has been steadily declining during recent decades. Expression of cyclooxygenase-2 (COX-2) is elevated in gastric carcinomas and in their precursor lesions.
Alexandra, Thiel, Johanna, Mrena, Ari, Ristimäki   +2 more
openaire   +2 more sources

Cyclooxygenase 2 and the kidney

Current Opinion in Nephrology and Hypertension, 2001
Cyclooxygenase metabolizes arachidonic acid to a family of bioactive fatty acids designated prostaglandins. Two isoforms of cyclooxygenase exist, designated COX1 and COX2. These isoforms are expressed in distinct but important areas of the kidney. COX1 predominates in vascular smooth muscle and collecting ducts, whereas COX2 predominates in the macula ...
M D, Breyer, R C, Harris
openaire   +2 more sources

Cyclooxygenase-2 and prostate carcinogenesis

Cancer Letters, 2003
In recent years a dramatic surge has occurred on studies defining to the role of cyclooxygenase (COX)-2 in causation and prevention of cancer. Prostaglandin (PG) endoperoxidase synthase also commonly referred to as COX is a key enzyme involved in the conversion of arachidonic acid to PGs and other eicosanoids.
Tajamul, Hussain, Sanjay, Gupta, Hasan, Mukhtar   +2 more
openaire   +2 more sources

Lung cancer and cyclooxygenase-2

The Annals of Thoracic Surgery, 2003
Lung cancer is by far the leading cause of cancer-related death. Overall survival is poor and has not improved substantially over the last half century. It is clear that new approaches are needed and these should include prevention, screening for early detection, and novel treatments based on our understanding of the molecular biology of this disease ...
J Esteban, Castelao, Robert D, Bart, Costanzo A, DiPerna, Eric M, Sievers, Ross M, Bremner   +4 more
openaire   +2 more sources

Cyclooxygenase-2 Inhibitors

Anesthesia & Analgesia, 2003
Kristi W, Kelley, Leigh Ann, Ramsey
openaire   +4 more sources

Cloning and Expression of Cyclooxygenase-1 and Cyclooxygenase-2

2010
Cyclooxygenase (COX) enzymes play important roles in normal physiology and during inflammation of various cells and tissues. In order to help understand the functions of these enzymes, their genes can be cloned to facilitate the production of the proteins in recombinant form.
Nicholas R, Staten, Beverly A, Reitz
openaire   +2 more sources

[Cyclooxygenase-2 and cyclooxygenase-2 inhibitors in prostate cancer].

Zhonghua nan ke xue = National journal of andrology, 2009
Cyclooxygenase-2 (Cox-2) is over-expressed in prostate cancer (PCa) and involved in its development and progression by facilitating inflammatory response, reducing cell apoptosis, increasing angiogenesis and damaging DNA oxidation. Selective Cox-2 inhibitors suppress PCa growth through various channels and therefore have a promising application value ...
Song, Xu, Jian-Ping, Gao, Wen-Quan, Zhou
openaire   +1 more source

Cyclooxygenase-2

2011
openaire   +2 more sources