Neuroprotective efficacy of nimesulide against hippocampal neuronal damage following transient forebrain ischemia [PDF]
, 2002 Cyclooxygenase-2 is involved in the inflammatory component of the ischemic cascade, playing an important role in the delayed progression of the brain damage.
Alvarez, Dalia +7 more
core +1 more source
Acta Neuropathologica Communications, 2019 Acetylsalicylic acid has been linked to a lower risk for different cancer types, presumably through its inhibitory effect on cyclooxygenase 2.
Felix Behling +9 more
doaj +1 more source
Analysis of Gene Expression in Human Dermal Fibroblasts Treated with Senescence-Modulating COX Inhibitors [PDF]
Genomics & Informatics, 2017 We have previously reported that NS-398, a cyclooxygenase-2 (COX-2)–selective inhibitor, inhibited replicative cellular senescence in human dermal fibroblasts and skin aging in hairless mice. In contrast, celecoxib, another COX-2–selective inhibitor, and
Jeong A. Han, Jong-Il Kim
doaj +1 more source
Cyclooxygenase-2/prostaglandin E2 pathway orchestrates the replication of infectious bronchitis virus in chicken tracheal explants. [PDF]
Microbiol SpectrIn this study, we investigated the localized pathogenesis of infectious bronchitis virus (IBV) in chicken tracheal organ cultures (TOCs), focusing on the role of inducible cyclooxygenase (COX-2).
Mahmoud ME +7 more
europepmc +2 more sources
Role of shear stress in endothelial cell morphology and expression of cyclooxygenase isoforms [PDF]
, 2011 MEDLINE® is the source for the MeSH terms of this document.Objective-: The goal of this study was to examine the effect of chronic heterogeneous shear stress, applied using an orbital shaker, on endothelial cell morphology and the expression of ...
Berson, R.E. +9 more
core +1 more source
Cyclooxygenase-2 (COX-2) inhibitors: future therapeutic strategies for epilepsy management
Journal of Neuroinflammation, 2019 Epilepsy, a common multifactorial neurological disease, affects about 69 million people worldwide constituting nearly 1% of the world population.
C. Rawat +3 more
semanticscholar +1 more source
Cyclooxygenase-2 Expression in Bladder Cancer and Patient Prognosis: Results from a Large Clinical Cohort and Meta-Analysis [PDF]
, 2012 Aberrant overexpression of cyclooxygenase-2 (COX2) is observed in urothelial carcinoma of the bladder (UCB). Studies evaluating COX2 as a prognostic marker in UCB report contradictory results.
Adonina Tardón +10 more
core +7 more sources
Evaluation of cyclooxygenase 2- gene expression in benign and malignant ascites [PDF]
Reviews in Clinical Medicine, 2020 Introduction: This study aimed to evaluate the mRNA expression of cyclooxygenase-2 (Cox-2) in ascites caused by various diseases. Moreover, it was attempted to investigate its usefulness in the differential diagnosis between malignant and benign ascites.
Raheleh Jabini +2 more
doaj +3 more sources
Delayed treatment with nimesulide reduces measures of oxidative stress following global ischemic brain injury in gerbils [PDF]
, 2003 Metabolism of arachidonic acid by cyclooxygenase is one of the primary sources of reactive oxygen species in the ischemic brain. Neuronal overexpression of cyclooxygenase-2 has recently been shown to contribute to neurodegeneration following ischemic ...
Alvarez, Dalia +3 more
core +1 more source
Biomedicines, 2023 The ability of MSCs to modulate the inflammatory environment is well recognized, but understanding the molecular mechanisms responsible for these properties is still far from complete.
Agnieszka Kulesza +2 more
doaj +1 more source