Results 31 to 40 of about 207,862 (335)

Role of shear stress in endothelial cell morphology and expression of cyclooxygenase isoforms [PDF]

, 2011
MEDLINE® is the source for the MeSH terms of this document.Objective-: The goal of this study was to examine the effect of chronic heterogeneous shear stress, applied using an orbital shaker, on endothelial cell morphology and the expression of ...
Berson, R.E., Gorelik, J., Harrington, L.S., Lundberg, M.H., Mitchell, J.A., Moshkov, A.V., Potter, C.M.F., Warboys, C.M., Warner, T.D., Weinberg, P.D.   +9 more
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Cyclooxygenase‐2 in oligodendroglial neoplasms [PDF]

Cancer, 2003
AbstractBACKGROUNDAlthough increased expression of cyclooxygenase‐2 (COX‐2) has been described in association with a variety of neoplasms, including tumors of astrocytic derivation, limited data are available on COX‐2 expression in oligodendrogliomas.METHODSThe current study retrospectively reviewed 53 oligodendrogliomas and 7 oligodendroglioma ...
Raymond R. Tubbs, Andrew A. Kanner, Andrew A. Kanner, Michael A. Vogelbaum, Elias A. Castilla, Richard A. Prayson, Lisa A. Rybicki, Gene H. Barnett   +7 more
openaire   +3 more sources

Cyclooxygenase-2 in Cardiovascular Biology

Clinical Medicine Insights: Cardiology, 2008
Cyclooxygenase (COX), also known as prostaglandin endoperoxide synthase, is the key enzyme required for the conversion of arachidonic acid to prostaglandins. Two COX isoforms have been identified, COX-1 and COX-2.
Joseph F. Murphy
doaj   +1 more source

The relationship between angiogenesis and cyclooxygenase-2 expression in prostate cancer [PDF]

, 2005
<b>OBJECTIVE</b>: To test the hypothesis that angiogenesis in prostate cancer is associated with tumour invasion and metastasis, and that this is mediated through increased cyclooxygenase-2 (COX-2) expression.
Bartlett, J.M.S., Edwards, J., Mukherjee, R., Underwood, M.A.   +3 more
core   +1 more source

Changing prostaglandin E2 (PGE2) signaling during lesional progression and exacerbation of endometriosis by inhibition of PGE2 receptor EP2 and EP4

Reproductive Medicine and Biology, 2022
Purpose We investigated the change, if any, in prostaglandin E2 (PGE2) signaling in endometriotic lesions of different developmental stages in mouse.
Qingqing Huang, Xishi Liu, Sun‐Wei Guo
doaj   +1 more source

Synthesis, in vitro, and in vivo biological evaluation and molecular docking simulations of chiral alcohol and ether derivatives of the 1,5-diarylpyrrole scaffold as novel anti-inflammatory and analgesic agents. [PDF]

, 2008
Following our previous research on anti-inflammatory drugs (NSAIDs), we report here the synthesis of chiral 1,5-diarylpyrroles derivatives that were characterized for their in vitro inhibitory effects toward cyclooxygenase (COX) isozymes.
ANZELLOTTI P., ANZINI M., BIAVA M., BOTTA M., CIRILLI R., FERRETTI R., FORLI ., GALLINELLA B., GHELARDINI C., GIORDANI A., LA TORRE F., MAKOVEC F., MANETTI F., NORCINI M., PATRIGNANI P., PERGOLA C., POCE G., PORRETTA G. C., ROSSI, ANTONIETTA, SAUTEBIN, LIDIA, SUPINO S.   +20 more
core   +1 more source

Cyclooxygenase 2 Promotes Proliferation and Invasion in Ovarian Cancer Cells via the PGE2/NF-κB Pathway

Cell Transplantation, 2019
Ovarian cancer is the leading cause of death among gynecological malignancies. Cyclooxygenase 2 is widely expressed in various cancer cells and participates in the occurrence and development of tumors by regulating a variety of downstream signaling ...
Xiao Zhang, Keqin Yan, Lin Deng, Jing Liang, Haiyan Liang, Dingqing Feng, Bin Ling   +6 more
doaj   +1 more source

Gut dysbacteriosis attenuates resistance to Mycobacterium bovis infection by decreasing cyclooxygenase 2 to inhibit endoplasmic reticulum stress

Emerging Microbes and Infections, 2022
The role of gut microbiota has been described as an important influencer of the immune system. Gut-lung axis is critical in the prevention of mycobacterium infection, but the specific mechanism, by which dysbiosis affects tuberculosis, has not been ...
Haoran Wang, Jiao Yao, Yulan Chen, Yuanzhi Wang, Yiduo Liu, Yi Liao, Zhengmin Liang, Yu hui Dong, Mengjin Qu, Xin Ge, Xiangmei Zhou   +10 more
doaj   +1 more source

Selective COX-2 inhibitors and risk of myocardial infarction [PDF]

, 2005
Selective inhibitors of cyclooxygenase- 2 ( COX- 2, ` coxibs') are highly effective anti-inflammatory and analgesic drugs that exert their action by preventing the formation of prostanoids.
Klauss, V., Krotz, F., Schiele, T. M., Sohn, Hae-Young   +3 more
core   +1 more source

Ascorbic acid enhances the inhibitory effect of aspirin on neuronal cyclooxygenase-2-mediated prostaglandin E2 production. [PDF]

, 2006
Inhibition of neuronal cyclooxygenase-2 (COX-2) and hence prostaglandin E2 (PGE2) synthesis by non-steroidal anti-inflammatory drugs has been suggested to protect neuronal cells in a variety of pathophysiological situations including Alzheimer's disease ...
Akundi, Ravi S., Appel, Kurt, Bhatia, Harsharan S., Candelario-Jalil, Eduardo, Fiebich, Bernd L., Hull, Michael, Lieb, Klaus, Munoz, Eduardo   +7 more
core   +1 more source