Results 31 to 40 of about 22,053,927 (171)
Cell Transplantation, 2019 Ovarian cancer is the leading cause of death among gynecological malignancies. Cyclooxygenase 2 is widely expressed in various cancer cells and participates in the occurrence and development of tumors by regulating a variety of downstream signaling ...
Xiao Zhang +6 more
doaj +1 more source
OncoTarget, 2017 To investigate the mechanism of cyclooxygenase 2 (COX2) in learning and memory impairments in rats subjected to chronic unpredictable mild stress (CUMS), meloxicam was used intragastrically to inhibit the activity of cyclooxygenase 2.
Ying Luo +4 more
semanticscholar +1 more source
Role of Modulator of Inflammation Cyclooxygenase-2 in Gammaherpesvirus Mediated Tumorigenesis
Frontiers in Microbiology, 2017 Chronic inflammation is recognized as a threat factor for cancer progression. Release of inflammatory molecules generates microenvironment which is highly favorable for development of tumor, cancer progression and metastasis.
J. Gandhi +4 more
semanticscholar +1 more source
Crystal structure of rofecoxib bound to human cyclooxygenase-2.
Acta Crystallographica Section F Structural Biology Communications, 2016 Rofecoxib (Vioxx) was one of the first selective cyclooxygenase-2 (COX-2) inhibitors (coxibs) to be approved for use in humans. Within five years after its release to the public, Vioxx was withdrawn from the market owing to the adverse cardiovascular ...
B. Orlando, M. Malkowski
semanticscholar +1 more source
$N=2$ Super-$W_3^{(2)}$ Algebra in Superfields [PDF]
Mod. Phys. Lett. A10 (1995) 2439, 1995 We present a manifestly $N=2$ supersymmetric formulation of $N=2$ super-$W_3^{(2)}$ algebra (its classical version) in terms of the spin 1 unconstrained supercurrent generating a $N=2$ superconformal subalgebra and the spins 1/2, 2 bosonic and spins 1/2, 2 fermionic constrained supercurrents. We consider a superfield reduction of $N=2$ super-$W_3^{(2)}$
arxiv +1 more source
Cyclooxygenase-2 expression in cervical cancer [PDF]
Vojnosanitetski Pregled, 2014 Background/Aim. Cyclooxygenase (COX) or prostaglandin H2 synthase is the first enzyme that catalyzes the first two steps in the biosynthesis of prostaglandins from arachidonic acid.
Mandić Aljoša +4 more
doaj +1 more source
Coherent State Construction of Representations of osp(2|2) and Primary Fields of osp(2|2) Conformal Field Theory [PDF]
Phys.Lett. A327 (2004) 442-451, 2003 Representations of the superalgebra $osp(2|2)$ and current superalgebra $osp(2|2)^{(1)}_k$ in the standard basis are investigated. All finite-dimensional typical and atypical representations of $osp(2|2)$ are constructed by the vector coherent state method.
arxiv +1 more source
Современная ревматология, 2016 Inflammation is the most important element in the pathogenesis of major human diseases. It determines the fundamental value of anti-inflammatory therapy in the modern concept of targeted pathogenetic treatment.
A. E. Karateev, T. L. Aleinikova
doaj +1 more source
Bioinformatic Scaling of Allosteric Interactions in Biomedical Isozymes [PDF]
, 2015 Allosteric (long-range) interactions can be surprisingly strong in proteins of biomedical interest. Here we use bioinformatic scaling to connect prior results on nonsteroidal anti-inflammatory drugs to promising new drugs that inhibit cancer cell metabolism.
arxiv +1 more source
Variations of the Hidden Sector in a Realistic Intersecting Brane Model [PDF]
J.Phys.G35:095008,2008, 2007 Recently, we discussed the first example of a phenomenologically realistic intersecting D6-brane model. In this model, the gauge symmetry in the hidden sector is USp(2)_1 x USp(2)_2 x USp(2)_3 x USp(2)_4. However, we find that the USp(2)_1 x USp(2)_2 gauge symmetry can be replaced by an U(2)_{12} gauge symmetry, and/or the USp(2)_3 x USp(2)_4 gauge ...
arxiv +1 more source