Results 41 to 50 of about 216,666 (331)

Arzanol, a prenylated heterodimeric phloroglucinyl pyrone, inhibits eicosanoid biosynthesis and exhibits anti-inflammatory efficacy in vivo. [PDF]

, 2011
Based on its capacity to inhibit in vitro HIV-1 replication in T cells and the release of pro-inflammatory cytokines in monocytes, the prenylated heterodimeric phloroglucinyl α-pyrone arzanol was identified as the major anti-inflammatory and anti-viral ...
Appendino G, Bauer J, Dehm F, Koeberle A, Northoff H, Pollastro F, ROSSI, ANTONIETTA, SAUTEBIN, LIDIA, Werz O.   +8 more
core   +1 more source

Phosphatidylinositol transfer protein α regulates growth and apoptosis of NIH3T3 cells

Journal of Lipid Research, 2004
Mouse fibroblast cells overexpressing phosphatidylinositol transfer protein α [PI-TPα; sense PI-TPα (SPIα) cells] show a significantly increased rate of proliferation and an extreme resistance toward ultraviolet- or tumor necrosis factor-α-induced ...
Martijn Schenning, Claudia M. van Tiel, Daniëlle van Manen, Jord C. Stam, Barend M. Gadella, Karel W.A. Wirtz, Gerry T. Snoek   +6 more
doaj   +1 more source

Systematic study of constitutive cyclo-oxygenase-2 expression: role of NFκB and NFAT transcriptional pathways [PDF]

, 2015
Cyclooxygenase-2 (COX-2) is an inducible enzyme that drives inflammation and is the therapeutic target for widely used nonsteroidal antiinflammatory drugs (NSAIDs).
Ahmetaj-Shala, B, Berglund, LM, Chan, MV, Garcia-Vaz, E, Gomez, MF, Herschman, HR, Jiao, J, Kirkby, NS, Mitchell, JA, Verdu, EF, Wallace, JL, Zaiss, AK   +11 more
core   +1 more source

Gut dysbacteriosis attenuates resistance to Mycobacterium bovis infection by decreasing cyclooxygenase 2 to inhibit endoplasmic reticulum stress

Emerging Microbes and Infections, 2022
The role of gut microbiota has been described as an important influencer of the immune system. Gut-lung axis is critical in the prevention of mycobacterium infection, but the specific mechanism, by which dysbiosis affects tuberculosis, has not been ...
Haoran Wang, Jiao Yao, Yulan Chen, Yuanzhi Wang, Yiduo Liu, Yi Liao, Zhengmin Liang, Yu hui Dong, Mengjin Qu, Xin Ge, Xiangmei Zhou   +10 more
doaj   +1 more source

Circulating microparticles from patients with obstructive sleep apnea enhance vascular contraction: mandatory role of the endothelium [PDF]

, 2012
Obstructive sleep apnea (OSA) is characterized by repetitive apnea-hypopnea cycles during sleep associated with oxygen desaturation and sleep disruption.
A. Gaceb, C. Contreras, D. Prieto, F. Gagnadoux, K. Fatoumata, M.C. Martinez, P. Priou, R. Andriantsitohaina, S. Tual-Chalot, W. Trzepizur   +9 more
core   +4 more sources

SELECTIVE CYCLOOXYGENASE-2 INHIBITORS

Rheumatic Disease Clinics of North America, 1999
The identification of COX-2 less than a decade ago has been followed by an unprecedented period of discovery and drug development. An awareness of the existence of two COX isoforms has led to potential novel insights into disease pathogenesis (arthritis, Alzheimer's disease, cancer) and the regulation of normal physiology (brain, kidney).
B D, Golden, S B, Abramson
openaire   +2 more sources

Changing prostaglandin E2 (PGE2) signaling during lesional progression and exacerbation of endometriosis by inhibition of PGE2 receptor EP2 and EP4

Reproductive Medicine and Biology, 2022
Purpose We investigated the change, if any, in prostaglandin E2 (PGE2) signaling in endometriotic lesions of different developmental stages in mouse.
Qingqing Huang, Xishi Liu, Sun‐Wei Guo
doaj   +1 more source

Survival for Children Diagnosed With Wilms Tumour (2012–2022) Registered in the UK and Ireland Improving Population Outcomes for Renal Tumours of Childhood (IMPORT) Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background The Improving Population Outcomes for Renal Tumours of childhood (IMPORT) is a prospective clinical observational study capturing detailed demographic and outcome data on children and young people diagnosed with renal tumours in the United Kingdom and the Republic of Ireland.
Naomi Ssenyonga, Angela Lopez‐Cortes, Reem Al‐Saadi, Suzanne Tugnait, Kristina Dzhuma, Catriona Duncan, Gordan Vujanic, Tanzina Chowdhury, Claudia Allemani, Michel P. Coleman, Kathy Pritchard‐Jones, the Children's Cancer and Leukaemia Group (CCLG) Renal Tumour Special Interest Group, Hugh Bishop, Anthony McCarthy, Pamela Kearns, Helen Rees, Amos Burke, Meriel Jenney, Jane Pears, Hamish Wallace, Milind Ronghe, Tanzina Chowdhury, Susan Picton, Emma Ross, Lisa Howell, Bernadette Brennan, Gail Halliday, Richard Grundy, Shaun Wilson, Sucheta Vaidya, Daniel Yeomanson, Jessica Bate, Vesna Pavasovic, Jessica Bate, Sabine Irtan, Jesper Brok, Minou Oostveen, Kristina Dzhuma, Mark Weeks, Richard Williams, Mark Powis, Max Pachl, Bruce Okoye, Naima Smeulders, Gordan Vujanic, Oystein Olsen, Tom Watson, Susan Shelmerdine, Dan Saunders, Angela Lopez-Cortes, Taryn Treger, Tom Jackson, Suzanne Tugnait, Lisa Howell, Tanzina Chowdhury, Sam Behjati, Angela Polanco   +56 more
wiley   +1 more source

Expression of mRNA for phospholipase A(2), cyclooxygenases, and lipoxygenases in cultured human umbilical vascular endothelial and smooth muscle cells and in biopsies from umbilical arteries and veins [PDF]

, 1998
Arachidonic acid (AA) is released by phospholipase A(2) (PLA(2)) and then converted into vasoactive and inflammatory eicosanoids by cyclooxygenases (COX) and lipoxygenases (LOX).
Carlsson, Maria, Gidlöf, Anders, Sirsjö, Allan, Söderkvist, Peter, Uhl, Eberhard, Öst, Martin   +5 more
core   +1 more source

Influence of Inhibition of COX-2-Dependent Lipid Metabolism on Regulation of UVB-Induced Keratinocytes Apoptosis by Cannabinoids

Biomolecules, 2022
Inflammation and apoptosis are regulated by similar factors, including ultraviolet B (UVB) radiation and cannabinoids, which are metabolized by cyclooxygenase-2 (COX-2) into pro-apoptotic prostaglandin derivatives.
Piotr Wójcik, Michał Biernacki, Natalia Domian, Neven Žarković, Elżbieta Skrzydlewska   +4 more
doaj   +1 more source