Results 41 to 50 of about 21,811,854 (372)

The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis.

New England Journal of Medicine, 2000
BACKGROUND Patients with familial adenomatous polyposis have a nearly 100 percent risk of colorectal cancer. In this disease, the chemopreventive effects of nonsteroidal antiinflammatory drugs may be related to their inhibition of cyclooxygenase-2 ...
G. Steinbach, P. Lynch, R. Phillips, M. Wallace, E. Hawk, G. Gordon, Naoki Wakabayashi, B. Saunders, Yu Shen, T. Fujimura, L. Su, B. Levin, L. Godio, S. Patterson, M. Rodriguez-Bigas, Susan L. Jester, K. King, M. Schumacher, J. Abbruzzese, R. Dubois, W. Hittelman, Stuart Zimmerman, J. Sherman, G. Kelloff   +23 more
semanticscholar   +1 more source

Changing prostaglandin E2 (PGE2) signaling during lesional progression and exacerbation of endometriosis by inhibition of PGE2 receptor EP2 and EP4

Reproductive Medicine and Biology, 2022
Purpose We investigated the change, if any, in prostaglandin E2 (PGE2) signaling in endometriotic lesions of different developmental stages in mouse.
Qingqing Huang, Xishi Liu, Sun‐Wei Guo
doaj   +1 more source

Research progress on COX-2/PGE₂/EP₄ signaling axis in colon cancer

Zhongguo linchuang yanjiu, 2023
The expression of cyclooxygenase 2 (COX-2) was up-regulated and prostaglandin E2 (PGE2) was significantly increased in colon cancer patients. As the main prostaglandin produced by COX-2, PGE2 plays an important role in angiogenesis, survival, invasion ...
ZHENG Lirong, DU Haoyang, ZHANG Ruifen, ZHANG Hairong, BAO Aruhan, YU Lei, CUI Hongwei   +6 more
doaj   +1 more source

Neurobiology and Therapeutic Potential of Cyclooxygenase-2 (COX-2) Inhibitors for Inflammation in Neuropsychiatric Disorders

Frontiers in Psychiatry, 2019
Neuropsychiatric disorders, such as depression, bipolar disorder, schizophrenia, obsessive-compulsive disorder, and neurodevelopmental disorders such as autism spectrum disorder, are associated with significant illness burden.
Rickinder Sethi, N. Gómez-Coronado, A. Walker, O. Robertson, Bruno Agustini, M. Berk, S. Dodd   +6 more
semanticscholar   +1 more source

Cyclooxygenase-2 in Cardiovascular Biology

Clinical Medicine Insights: Cardiology, 2008
Cyclooxygenase (COX), also known as prostaglandin endoperoxide synthase, is the key enzyme required for the conversion of arachidonic acid to prostaglandins. Two COX isoforms have been identified, COX-1 and COX-2.
Joseph F. Murphy
doaj   +1 more source

Preoperative oral treatment with cyclooxygenase-2 inhibitor for cystitis glandularis. [PDF]

IJU Case Rep
Introduction A previous report has shown that cyclooxygenase‐2 inhibitors can prevent the recurrence of cystitis glandularis postoperatively. Herein, we present a case of cystitis glandularis in which the tumor volume was markedly reduced by preoperative
Yanagi M, Motoda N, Katsu A, Kono H, Kimata R, Hamasaki T, Kondo Y.   +6 more
europepmc   +2 more sources

The relationship between angiogenesis and cyclooxygenase-2 expression in prostate cancer [PDF]

, 2005
<b>OBJECTIVE</b>: To test the hypothesis that angiogenesis in prostate cancer is associated with tumour invasion and metastasis, and that this is mediated through increased cyclooxygenase-2 (COX-2) expression.
Bartlett, J.M.S., Edwards, J., Mukherjee, R., Underwood, M.A.   +3 more
core   +1 more source

Gut dysbacteriosis attenuates resistance to Mycobacterium bovis infection by decreasing cyclooxygenase 2 to inhibit endoplasmic reticulum stress

Emerging Microbes and Infections, 2022
The role of gut microbiota has been described as an important influencer of the immune system. Gut-lung axis is critical in the prevention of mycobacterium infection, but the specific mechanism, by which dysbiosis affects tuberculosis, has not been ...
Haoran Wang, Jiao Yao, Yulan Chen, Yuanzhi Wang, Yiduo Liu, Yi Liao, Zhengmin Liang, Yu hui Dong, Mengjin Qu, Xin Ge, Xiangmei Zhou   +10 more
doaj   +1 more source

Selective COX-2 inhibitors and risk of myocardial infarction [PDF]

, 2005
Selective inhibitors of cyclooxygenase- 2 ( COX- 2, ` coxibs') are highly effective anti-inflammatory and analgesic drugs that exert their action by preventing the formation of prostanoids.
Klauss, V., Krotz, F., Schiele, T. M., Sohn, Hae-Young   +3 more
core   +1 more source

Cyclooxygenase-2 inhibitors as a therapeutic target in inflammatory diseases.

Current Medicinal Chemistry, 2018
Inflammation plays a crucial role in the development of many complex diseases and disorders including autoimmune diseases, metabolic syndrome, neurodegenerative diseases, and cardiovascular pathologies.
M. Ferrer, Carla Busquests-Cortes, X. Capó, S. Tejada, J. Tur, A. Pons, A. Sureda   +6 more
semanticscholar   +1 more source