Results 51 to 60 of about 216,666 (331)

A Systematic Review of Evidence on the Clinical Effectiveness of Surveillance Imaging in Children With Medulloblastoma and Ependymoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Surveillance imaging aims to detect tumour relapse before symptoms develop, but it's unclear whether earlier detection of relapse leads to better outcomes in children and young people (CYP) with medulloblastoma and ependymoma. This systematic review aims to identify relevant literature to determine the efficacy of surveillance magnetic ...
Lucy Shepherd, Melissa Taylor, Helen Fulbright, Bob Phillips   +3 more
wiley   +1 more source

Consequences of altered eicosanoid patterns for nociceptive processing in mPGES-1-deficient mice [PDF]

, 2007
Cyclooxygenase-2 (COX-2)-dependent prostaglandin (PG) E2 synthesis in the spinal cord plays a major role in the development of inflammatory hyperalgesia and allodynia. Microsomal PGE2 synthase-1 (mPGES-1) isomerizes COX-2-derived PGH2 to PGE2.
Angioni, Carlo Federico, Becker, Wiebke, Brenneis, Christian, Coste, Ovidiu, Geisslinger, Gerd, Nusing, Rolf M., Popp, Laura, Schmidt, Ronald, Scholich, Klaus   +8 more
core   +1 more source

Prognostic Impact of Treatment Modalities, Including Targeted Compartmental Radio‐Immunotherapy, in a Cohort of Neuroblastoma Patients With CNS Metastases at Relapse

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neuroblastoma (NB) with central nervous system (CNS) metastases is rare at diagnosis, but occurs more often during relapse/progression. Patients with CNS metastases face a dismal prognosis, with no standardized curative treatment available.
Vicente Santa‐Maria Lopez, Anna Felip‐Badia, Marina Caballero‐Bellon, Nazaret Sanchez‐Sierra, Alicia Castañeda, Moira Garraus, Maite Gorostegui, Margarida Simão‐Rafael, Juan Pablo Muñoz, Marta Perez‐Somarriba, Salvador Mañe, Mariana Cecilia Planells, Sara Perez‐Jaume, Jaume Mora   +13 more
wiley   +1 more source

Evidence that links loss of cyclooxygenase-2 with increased asymmetric dimethylarginine : novel explanation of cardiovascular side effects associated with anti-inflammatory drugs [PDF]

, 2014
© 2014 The Authors. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.BACKGROUND: Cardiovascular ...
Ahmetaj-Shala, Blerina, Al'Yamani, Malak, Armstrong, Paul C. J., Kirkby, Nicholas S., Knowles, Rebecca, Leiper, James, Mackenzie, Louise, Mazi, Sarah, Mitchell, Jane A., Nüsing, Rolf M., Tomlinson, James A. P., Tucker, Arthur T., Wang, Zhen, Warner, Timothy D.   +13 more
core   +4 more sources

Antitumor enhancement of celecoxib, a selective Cyclooxygenase-2 inhibitor, in a Lewis lung carcinoma expressing Cyclooxygenase-2

Journal of Experimental & Clinical Cancer Research, 2008
Background The goal of this study was to determine the effects of a selective Cyclooxygenase (COX)-2 inhibitor on the inhibition of tumor growth and pulmonary metastasis in a Lewis Lung Carcinoma (LLC) animal model. Methods For immunoblot analysis of COX-
Han Jae, Oh Young, Park Won, Pyo Hongryull   +3 more
doaj   +1 more source

Improved Outcomes for Older Children, Adolescents, and Young Adults With Neuroblastoma in the Post‐Immunotherapy Era: An Updated Report From the International Neuroblastoma Risk Group

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background We describe clinical and biologic characteristics of neuroblastoma in older children, adolescents, and young adults (OCAYA); describe survival outcomes in the post‐immunotherapy era; and identify if there is an age cut‐off that best discriminates outcomes.
Rebecca J. Deyell, Kavitha Srivatsa, Paola Angelini, Pei‐Chi Kao, Brady Payne, Arlene Naranjo, Sveva Castelli, Miho Kato, Miki Ohira, Ulriche Pöetschger, Yaël Mossé, Lucas Moreno, Meredith S. Irwin, Ramya Ramanujachar, Wendy B. London   +14 more
wiley   +1 more source

Staphylococcus aureus enterotoxin B regulates prostaglandin E-2 synthesis, growth, and migration in nasal tissue fibroblasts [PDF]

, 2008
Background. Superantigens and eicosanoids are important amplifiers and regulators of inflammation in airway diseases. We therefore studied the possible influence of Staphylococcus aureus enterotoxin B ( SEB) on the cyclooxygenase ( COX) pathway and basic
Bachert, Claus, Claeys, Cindy, Perez Novo, Claudina, Van Cauwenberge, Paul, Waeytens, Anouk   +4 more
core   +2 more sources

COX-2 “Cyclooxygenase 2“as a Prognostic marker in Breast Cancer

SVU - International Journal of Medical Sciences, 2021
Background: Breast cancer is the most commonly diagnosed cancer and the leading cause of cancer death among women in both developed and developing countries.
Fatma Zakaria Abdel-rahman , Amen H. Zaky, Ashraf Zedan, Tarek M. Elsaba, Adel Gabr   +4 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Common promoter variant in cyclooxygenase-2 represses gene expression: evidence of role in acute-phase inflammatory response [PDF]

, 2002
Objective: Cyclooxygenase (COX)-2 is a key regulatory enzyme in the synthesis of prostanoids associated with trauma and inflammation. We investigated the COX-2 gene for functional variants that may influence susceptibility to disease.
Brull, D.J., Hill, M.R., Humphries, S.E., Laurent, G.J., Marshall, R.P., McAnulty, R.J., Papafili, A.   +6 more
core   +1 more source