Results 321 to 330 of about 995,042 (360)

Efficacy of cyclooxygenase-2–specific inhibitors

The American Journal of Medicine, 2001
Conventional nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit both cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). The clinical efficacy of NSAIDs is primarily related to the inhibition of COX-2 activity, whereas much of the toxicity, particularly gastrointestinal toxicity, is related to COX-1 inhibition.
G W, Cannon, F C, Breedveld
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Cyclooxygenase-2 Inhibitors in Glioma Therapy

American Journal of Therapeutics, 2004
The cyclooxygenase enzyme is a prostaglandin synthase that has two isoforms, cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). Upregulation of the COX-2 isoform in many cancers has led to investigation regarding the potential role of this enzyme in oncogenesis.
Pierre, Giglio, Victor, Levin
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Cyclooxygenase-2 inhibitors in colorectal cancer

Seminars in Oncology, 2003
Cyclooxygenase (COX) enzyme-dependent arachidonic acid metabolites occupy key positions in important physiologic processes such as immunity, reproduction, and vascular integrity. Large retrospective and prospective population-based studies have shown that the use of both nonselective, nonsteroidal anti-inflammatory drugs and selective COX-2 inhibitors ...
Jan, Stoehlmacher, Heinz-Josef, Lenz
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Pyridazinones as selective cyclooxygenase-2 inhibitors

Bioorganic & Medicinal Chemistry Letters, 2003
Pyridazinone was found to be an excellent core template for selective COX-2 inhibitors. Two potent, selective and orally active COX-2 inhibitors, which were highly efficacious in rat paw edema and rat pyresis models, have been obtained.
Chun Sing, Li, Christine, Brideau, Chi Chung, Chan, Chantal, Savoie, David, Claveau, Stella, Charleson, Robert, Gordon, Gillian, Greig, Jacques Yves, Gauthier, Cheuk K, Lau, Denis, Riendeau, Michel, Thérien, Elizabeth, Wong, Petpiboon, Prasit   +13 more
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The Coxibs, Selective Inhibitors of Cyclooxygenase-2

New England Journal of Medicine, 2001
Nonsteroidal antiinflammatory drugs (NSAIDs) are widely used to treat arthritis, menstrual pain, and headache. Although they are effective, their long-term use is limited by gastrointestinal effects such as dyspepsia and abdominal pain and, less often, gastric or duodenal perforation or bleeding.
FitzGerald, Garret A., Patrono, Carlo
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Cardiovascular effects of cyclooxygenase-2 inhibitors

Current Opinion in Internal Medicine, 2008
Arthritis and musculoskeletal disorders are highly prevalent and management often involves the use of nonsteroidal antiinflammatory drugs. Cyclooxygenase-2 enzyme inhibitors are newer selective nonsteroidal antiinflammatory drugs that purport to exhibit less gastrointestinal toxicity than traditional nonsteroidal antiinflammatory drugs.
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4,5-Diaryloxazole inhibitors of cyclooxygenase-2 (COX-2)

Medicinal Research Reviews, 1999
A series of methysulfonyl or sulfonamido substituted 4,5-diaryloxazole were prepared and evaluated for their ability to inhibit the inducible form of cyclooxygenase (COX-2) in vitro and in vivo. Several unique substitution patterns were identified that led to potent and selective inhibitors of COX-2.
J J, Talley, S R, Bertenshaw, D L, Brown, J S, Carter, M J, Graneto, C M, Koboldt, J L, Masferrer, B H, Norman, D J, Rogier, B S, Zwwifel, K, Seibert   +10 more
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Cyclooxygenase-2 inhibitors and cardiovascular risk

Current Opinion in Cardiology, 2006
Cyclooxygenase-2 inhibitors, or coxibs, designed to provide comparable pain relief to traditional nonsteroidal anti-inflammatory drugs with reduced risk of gastrointestinal complications, have come under substantial recent scrutiny because of an increased likelihood of adverse cardiovascular events associated with their use.Data concerning the ...
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Cyclooxygenase-2 Inhibitors

Anesthesia & Analgesia, 2003
Kristi W, Kelley, Leigh Ann, Ramsey
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Cardiovascular effects of selective cyclooxygenase-2 inhibitors

Expert Review of Cardiovascular Therapy, 2004
Selective cyclooxygenase-2 inhibitors represent a significant advance in the management of inflammatory disorders. They have similar efficacy to nonselective 'conventional' nonsteroidal anti-inflammatory drugs, but a superior gastrointestinal safety profile.
Henry, Krum, Danny, Liew, Juan, Aw, Steven, Haas   +3 more
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