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Hemicrania Continua Responds to Cyclooxygenase‐2 Inhibitors
Headache: The Journal of Head and Face Pain, 2002Background.—Hemicrania continua is a primary headache disorder defined by its absolute responsiveness to indomethacin. We report the treatment response to two cyclooxygenase‐2 inhibitors, celecoxib and rofecoxib, in a series of patients with hemicrania continua.
Mario F P, Peres, Stephen D, Silberstein
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Selective Cyclooxygenase-2 Inhibitors
2004Publisher Summary Cyclooxygenase (prostaglandin G/H synthase) catalyzes the conversion of arachidonic acid (AA) into prostaglandin H2 as the first committed step of prostaglandin biosynthesis. This enzyme is known to be the target of acetyl salicylic acid (ASA) and non-steroidal anti-inflammatory drugs (NSAIDs).
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Gastroduodenal Safety of Cyclooxygenase-2 Inhibitors
Current Pharmaceutical Design, 2003Cyclooxygenase-1 (COX-1) derived eicosanoids promote gastroprotective mucosal defenses and induce platelet aggregation. By sparing COX-1, COX-2 specific inhibitors provide effective anti-inflammatory and analgesic activity while substantially reducing the risk of peptic ulcer disease and GI bleeding compared to dual COX inhibitors (traditional NSAIDs).
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Selective inhibitors of cyclooxygenase-2
Expert Opinion on Therapeutic Patents, 1997Prostaglandins (PGs) produced by the inducible enzyme cyclooxygenase-2 (COX-2) are important mediators of pain and inflammation. In animals, selective inhibitors of COX-2 have been shown to be anti-inflammatory without typical non-steroidal anti-inflammatory drug (NSAID) side-effects. Research directed towards the identification of potent and selective
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[Coxibs: cyclooxygenase-2 inhibitors].
Wiener klinische Wochenschrift, 2001The oxygenating enzyme cyclooxygenase (COX) catalysis the conversion of arachidonic acid to proinflammatory prostaglandins. For many years it was thought that COX is a single enzyme that is present constitutively in most tissues. But in the late 80ies COX activity was found to be increased in inflammatory states with cytokines and bacterial ...
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[Cyclooxygenase-2 and cyclooxygenase-2 inhibitors in prostate cancer].
Zhonghua nan ke xue = National journal of andrology, 2009Cyclooxygenase-2 (Cox-2) is over-expressed in prostate cancer (PCa) and involved in its development and progression by facilitating inflammatory response, reducing cell apoptosis, increasing angiogenesis and damaging DNA oxidation. Selective Cox-2 inhibitors suppress PCa growth through various channels and therefore have a promising application value ...
Song, Xu, Jian-Ping, Gao, Wen-Quan, Zhou
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