Results 21 to 30 of about 2,867,692 (324)
Molecules, 2019 Prostaglandins and inhibitors of their synthesis (cyclooxygenase (COX) inhibitors, non-steroidal anti-inflammatory drugs) were shown to play a significant role in the regulation of hematopoiesis. Partly due to their hematopoiesis-modulating effects, both
Michal Hofer +2 more
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Cyclooxygenase-2 (COX-2) inhibitors: future therapeutic strategies for epilepsy management
Journal of Neuroinflammation, 2019 Epilepsy, a common multifactorial neurological disease, affects about 69 million people worldwide constituting nearly 1% of the world population.
C. Rawat +3 more
semanticscholar +1 more source
NSAIDs and Cancer Resolution: New Paradigms beyond Cyclooxygenase
International Journal of Molecular Sciences, 2022 Acute inflammation or resolved inflammation is an adaptive host defense mechanism and is self-limiting, which returns the body to a state of homeostasis.
Oluwafunke R. Kolawole, K. Kashfi
semanticscholar +1 more source
Antimetastatic activity of a cyclooxygenase-2 inhibitor [PDF]
British Journal of Cancer, 2004 Cyclooxygenase-2 (COX-2) expression is increased in breast cancer and surgery has been shown to increase the growth of metastatic tumours. We investigated the effect of selective COX-2 inhibition on the growth of metastases in either an experimental metastasis model or following excision of a murine primary breast tumour.
Judith H. Harmey +4 more
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Drugs & Aging, 2019 ObjectiveOur aim was to assess the safety of cyclooxygenase-2 (COX-2) inhibitors in the management of osteoarthritis (OA) in a systematic review and meta-analysis of randomized, placebo-controlled trials.MethodsA comprehensive literature search was ...
E. Curtis +13 more
semanticscholar +1 more source
Фармакокинетика и Фармакодинамика, 2023 Effects of multiple-dose regimens (oral, daily, once a day for 15 days) of cyclooxygenase (COX) inhibitors etoricoxib (1 and 10 mg/kg), diclofenac sodium (1 and 5 mg/kg) and their combinations with 2-ethyl-6-methyl-3-hydroxypyridine succinate (mexidol 25
E. A. Ivanova +3 more
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SELECTIVE CYCLOOXYGENASE-2 INHIBITORS
Rheumatic Disease Clinics of North America, 1999 The identification of COX-2 less than a decade ago has been followed by an unprecedented period of discovery and drug development. An awareness of the existence of two COX isoforms has led to potential novel insights into disease pathogenesis (arthritis, Alzheimer's disease, cancer) and the regulation of normal physiology (brain, kidney).
Brian D. Golden, Steven B. Abramson
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PLoS ONE, 2019 Nonsteroidal anti-inflammatory drugs and acetaminophen are cyclooxygenase inhibitors commonly used as symptomatic medicines for myofascial pain syndrome.
Tetsuhiro Shimodaira +2 more
doaj +1 more source
Antiproliferative Benzoindazolequinones as Potential Cyclooxygenase-2 Inhibitors
Molecules, 2019 Quinones and nitrogen heterocyclic moieties have been recognized as important pharmacophores in the development of antitumor agents. This study aimed to establish whether there was any correlation between the in silico predicted parameters and the in ...
Aurora Molinari +7 more
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Individualized ibuprofen treatment using serial B-type natriuretic peptide measurement for symptomatic patent ductus arteriosus in very preterm infants [PDF]
Korean Journal of Pediatrics, 2017 PurposePlasma level of B-type natriuretic peptide (BNP), an emerging, sensitive, and specific biomarker of hemodynamically significant patent ductus arteriosus (PDA), rapidly decreases in infants receiving cyclooxygenase inhibitors for ductal closure. We
Jeonghee Shin +4 more
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