Results 41 to 50 of about 114,365 (325)

Docking Study, Synthesis, and Anti-Inflammatory Potential of Some New Pyridopyrimidine-Derived Compounds

Journal of Inflammation Research, 2022
Mohamed A Abdelgawad,1 Mohammad M Al-Sanea,1 Arafa Musa,2 Mohammed Elmowafy,3 Ashraf K El-Damasy,4 Amany A Azouz,5 Mohammed M Ghoneim,6 Rania R Bakr7 1Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, Al Jouf, 72341 ...
Abdelgawad MA, Al-Sanea MM, Musa A, Elmowafy M, El-Damasy AK, Azouz AA, Ghoneim MM, Bakr RR   +7 more
doaj  

Celecoxib inhibits proliferation and survival of chronic myelogeous leukemia (CML) cells via AMPK-dependent regulation of β-catenin and mTORC1/2. [PDF]

, 2016
CML is effectively treated with tyrosine kinase inhibitors (TKIs). However, the efficacy of these drugs is confined to the chronic phase of the disease and development of resistance to TKIs remains a pressing issue.
Calabretta, Bruno, Canonico, Pier Luigi, Condorelli, Fabrizio, De Dominici, Marco, Genazzani, Armando A, Gnemmi, Ilaria, Mariani, Samanta A., Minassi, Alberto, Minieri, Valentina, Riva, Beatrice, Salomoni, Paolo   +10 more
core   +2 more sources

Update on Cyclooxygenase-2 Inhibitors [PDF]

Clinical Journal of the American Society of Nephrology, 2006
Nonsteroidal anti-inflammatory drugs represent the most commonly used medications for the treatment of pain and inflammation, but numerous well-described side effects can limit their use. Cyclooxygenase-2 (COX-2) inhibitors were initially touted as a therapeutic strategy to avoid not only the gastrointestinal but also the renal and cardiovascular side ...
Raymond C, Harris, Matthew D, Breyer
openaire   +2 more sources

Wide therapeutic time window for nimesulide neuroprotection in a model of transient focal cerebral ischemia in the rat [PDF]

, 2004
Results from several studies indicate that cyclooxygenase-2 (COX-2) is involved ischemic brain injury. The purpose of this study was to evaluate the neuroprotective effects of the selective COX-2 inhibitor nimesulide on cerebral infarction and ...
Candelario-Jalil, Eduardo, Fiebich, Bernd L., García-Cabrera, Michel, González-Falcón, Armando, León, Olga S.   +4 more
core   +1 more source

Risk of acute myocardial infarction with nonselective non-steroidal anti-inflammatory drugs: a meta-analysis [PDF]

, 2006
The use of cyclo-oxygenase 2 selective nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with increased risk of acute myocardial infarction (AMI). The association between the risks of AMI with nonselective NSAIDs is less clear.
Langhorne, P., Madhok, R., Singh, G., Wu, O.   +3 more
core   +2 more sources

Can daily intake of aspirin and/or statins influence the behavior of non-muscle invasive bladder cancer? A retrospective study on a cohort of patients undergoing transurethral bladder resection [PDF]

, 2015
Background: This study aimed to evaluate the behavior of non-muscle-invasive bladder cancer (NMIBC) in patients submitted to transurethral bladder resection (TURB) comparing subjects in chronic therapy with aspirin, statins, or both drugs to untreated ...
Alessandro, Zucchi, Andrea, Fuschi, Carbone, Antonio, DE NUNZIO, Cosimo, Elisabetta, Costantini, Palleschi, Giovanni, Pastore, ANTONIO LUIGI, Petrozza, Vincenzo, Silvestri, Luigi, Yazan Al, Salhi   +9 more
core   +1 more source

Cyclooxygenase (cox) Inhibitors and the Intestine [PDF]

Journal of Veterinary Internal Medicine, 2007
Nonsteroidal anti‐inflammatory drugs (NSAIDs) have long been used for the treatment of pain and inflammation because of their inhibitory effects on cyclooxygenase (COX). For almost as long as NSAIDs have been in use, multiple adverse effects have been noted.
Dianne, Little, Samuel L, Jones, Anthony T, Blikslager   +2 more
openaire   +2 more sources

Evaluation of a Bayesian inference network for ligand-based virtual screening [PDF]

, 2009
Background Bayesian inference networks enable the computation of the probability that an event will occur. They have been used previously to rank textual documents in order of decreasing relevance to a user-defined query. Here, we modify the approach to
A Abdo, A Bender, AG Maldonado, AN Jain, AR Leach, AR Leach, Beining Chen, Christoph Mueller, CX Zhai, D Metzler, EJ Gardiner, EM Voorhees, G Salton, GW Bemis, H Eckert, H Turtle, J Bajorath, J Hert, J Hert, J-F Truchon, JA Grant, JD Holliday, JP Callan, JP Callan, JR Fischer, K Spärck Jones, K Spärck Jones, N Nikolova, P Prathipati, P Willett, P Willett, P Willett, P Willett, P Willett, Peter Willett, RC Glen, RD Brown, RP Sheridan, RP Sheridan, S Siegel, SJ Edgar, T Lengauer, T Strohman, TI Oprea, WR Greiff, X Chen   +45 more
core   +3 more sources

Prognostic Impact of Treatment Modalities, Including Targeted Compartmental Radio‐Immunotherapy, in a Cohort of Neuroblastoma Patients With CNS Metastases at Relapse

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neuroblastoma (NB) with central nervous system (CNS) metastases is rare at diagnosis, but occurs more often during relapse/progression. Patients with CNS metastases face a dismal prognosis, with no standardized curative treatment available.
Vicente Santa‐Maria Lopez, Anna Felip‐Badia, Marina Caballero‐Bellon, Nazaret Sanchez‐Sierra, Alicia Castañeda, Moira Garraus, Maite Gorostegui, Margarida Simão‐Rafael, Juan Pablo Muñoz, Marta Perez‐Somarriba, Salvador Mañe, Mariana Cecilia Planells, Sara Perez‐Jaume, Jaume Mora   +13 more
wiley   +1 more source

Assessment of Platelet Function in Traumatic Brain Injury—A Retrospective Observational Study in the Neuro-Critical Care Setting

Frontiers in Neurology, 2018
BackgroundDespite seemingly functional coagulation, hemorrhagic lesion progression is a common and devastating condition following traumatic brain injury (TBI), stressing the need for new diagnostic techniques.
Caroline Lindblad, Eric Peter Thelin, Eric Peter Thelin, Michael Nekludov, Arvid Frostell, David W. Nelson, Mikael Svensson, Bo-Michael Bellander   +7 more
doaj   +1 more source