Results 171 to 180 of about 32,096 (206)

Role of Cyclophilin A in HIV Replication

Future Virology, 2006
A review. More than a decade has passed since the discovery that the peptidyl prolyl isomerase cyclophilin A (CypA) specifically binds to a proline-rich sequence in HIV-1 capsid (CA) and is thereby incorporated into viral particles. Since then, a variety of possible functions of CypA in the HIV-1 replication cycle have been intensively investigated ...
Votteler, J., Wray, V., Schubert, U.S.
openaire   +2 more sources

Cyclophilin D as a Drug Target

Current Medicinal Chemistry, 2003
The mitochondrial permeability transition (MPT) plays an important role in damage-induced cell death, and agents inhibiting the MPT may have a therapeutic potential for treating human conditions such as ischemia/reperfusion injury, trauma, and neurodegenerative diseases.
Peter C, Waldmeier, Kaspar, Zimmermann, Ting, Qian, Marina, Tintelnot-Blomley, John J, Lemasters   +4 more
openaire   +2 more sources

Redox regulation of cyclophilin A by glutathionylation

PROTEOMICS, 2006
AbstractUsing redox proteomics techniques to characterize the thiol status of proteins in human T lymphocytes, we identified cyclophilin A (CypA) as a specifically oxidized protein early after mitogen activation. CypA is an abundantly expressed cytosolic protein, target of the immunosuppressive drug cyclosporin A (CsA), for which a variety of functions
Ghezzi, Pietro, Casagrande, Simona, Massignan, Tania, Basso, Manuela, Bellacchio, Emanuele, Mollica, Luca, Biasini, Emiliano, Tonelli, Rossella, Eberini, Ivano, Gianazza, Elisabetta, Dai, Wei Wei, Fratelli, Maddalena, Salmona, Mario, Sherry, Barbara, Bonetto, Valentina   +14 more
openaire   +2 more sources

Role of cyclophilin a during oncogenesis

Archives of Pharmacal Research, 2010
Cyclophilins (Cyps) are ubiquitously expressed proteins that are evolutionarily conserved. CypA is the most abundant among the Cyps and is expressed in the cytosol. With its chaperone and PPIase activities, CypA contributes to the maintenance of correct conformation of nascent or denatured proteins and also provides protection against environmental ...
openaire   +2 more sources

Cyclophilin A as a Target of Cisplatin Chemosensitizers

Current Cancer Drug Targets, 2014
Platinum-based chemotherapeutics are the mainstay of treatment of a range of tumors achieving high response rates but limited in the course of disease by appearance of drug resistance. Tumor cells respond with reduced uptake and increased intracellular inactivation of the drugs, as well as increased DNA repair and general resistance to ...
openaire   +2 more sources

Cyclophilin A/CD147 Interaction: A Promising Target for Anticancer Therapy

International Journal of Molecular Sciences, 2022
Hye Jin Jung, Jang Mi Han, Jung Hye Jin
exaly  

Delicate regulation of IL-1β-mediated inflammation by cyclophilin A

Cell Reports, 2022
Wenjun Liu, Wei Liu, Lei Sun
exaly  

Cyclophilin Inhibitors

Current Hepatitis Reports, 2012
Robert Flisiak, Anna Parfieniuk-Kowerda
openaire   +1 more source

Cyclophilin

Science-Business eXchange, 2014
openaire   +1 more source

Cyclophilin D Modulates Mitochondrial Acetylome

Circulation Research, 2013
Charles Steenbergen, Marjan Gucek, Elizabeth Murphy   +2 more
exaly