Results 191 to 200 of about 35,749 (233)
Neuroprotective role of pyrroloquinoline quinone in folate deficiency-induced blood-brain barrier disruption. [PDF]
Fluids Barriers CNSAboulhassane S +3 more
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Fish and Shellfish Immunology, 2011 Cyclophilin A (CypA) is a ubiquitously distributed intracellular protein belonging to the immunophilin family, which is recognized as the cell receptor for the potent immunosuppressive drug cyclosporine A.
Chunlin Wang
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RS cyclophilins: Identification of an NK-TR1-related cyclophilin
Gene, 1996We report the isolation of a large cyclophilin protein containing RS (arginine-serine) repeats from a yeast two-hybrid screen using ClK (CDC28/cdc2-like kinase) as a probe. This Clk associating RS-cyclophilin (CARS-Cyp) possesses 39% homology to the NK-TR1 (natural killer tumor recognition protein-1) we have previously characterized (Anderson et al ...
F P, Nestel +4 more
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Structure of recombinant human cyclophilin J, a novel member of the cyclophilin family
Acta Crystallographica Section D: Biological Crystallography, 2005Cyclophilins (CyPs) are a large class of highly conserved ubiquitous peptidyl-prolyl cis-trans isomerases. CyPs have also been identified as being a specific receptor for the immunosuppressive drug cyclosporin A and are involved in a variety of biological functions.
Zong-Xiang Xia
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Cyclophilin of Schistosoma japonicum
The Journal of Parasitology, 1992A 623-bp cDNA molecule encoding cyclophilin, a specific cyclosporin A-binding protein, has been isolated from Schistosoma japonicum using a heterologous cDNA probe from Echinococcus granulosus. The nucleotide sequence of this molecule has been determined, and the deduced amino acid sequence has revealed extensive homology with homologues of other ...
V P, Argaet, G F, Mitchell
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Clinics in Liver Disease, 2009
The percentage of patients chronically infected with hepatitis C virus (HCV) who have reached sustained antiviral response has increased since the introduction of the pegylated interferon-alpha (pIFNa) and ribavirin (RBV) treatment. However, the current standard pIFNa/RBV therapy not only has a low success rate (about 50%) but is often associated with ...
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The percentage of patients chronically infected with hepatitis C virus (HCV) who have reached sustained antiviral response has increased since the introduction of the pegylated interferon-alpha (pIFNa) and ribavirin (RBV) treatment. However, the current standard pIFNa/RBV therapy not only has a low success rate (about 50%) but is often associated with ...
openaire +2 more sources
Sequence conservation of schistosome cyclophilins
Molecular and Biochemical Parasitology, 1996Sequence conservation of schistosome ...
Klinkert Mq +4 more
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Role of Cyclophilins in Somatolactogenic Action
Annals of the New York Academy of Sciences, 2000Abstract: Prolactin (PRL) and growth hormone (GH) are members of the somatolactogenic hormone family, the pleiotropic actions of which are necessary for vertebrate growth and mammary differentiation. The basis for the specific function of these hormones has remained uncertain; however, their action is associated with internalization and translocation ...
M A, Rycyzyn, C V, Clevenger
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Oligopeptide cyclophilin inhibitors: A reassessment
European Journal of Medicinal Chemistry, 2011Potent cyclophilin A (CypA) inhibitors such as non-immunosuppressive cyclosporin A (CsA) derivatives have been already used in clinical trials in patients with viral infections. CypA is a peptidyl prolyl cis/trans isomerase (PPIase) that catalyzes slow prolyl bond cis/trans interconversions of the backbone of substrate peptides and proteins.
Michael, Schumann +4 more
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