Results 151 to 160 of about 30,484 (184)

Molecular Cloning and Characterization of Aspergillus nidulans Cyclophilin B

Fungal Genetics and Biology, 1999
Cyclophilins are an evolutionarily conserved family of proteins which serve as the intracellular receptors for the immunosuppressive drug cyclosporin A. Here we report the characterization of the first cyclophilin cloned from the filamentous fungus Aspergillus nidulans (CYPB).
J D, Joseph, J, Heitman, A R, Means
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Binding of Active Cyclosporins to Cyclophilin A and B, Complex Formation with Calcineurin A

Biochemical and Biophysical Research Communications, 1993
The binding properties of several active and inactive cyclosporins to the major intracellular receptor proteins, cyclophilin A and B, as well as the interaction with the phosphatase calcineurin were investigated by ELISA and by means of a photoaffinity labeled probe (PL-CS).
Ryffel B, Woerly G, Murray M, Eugster HP, Car B   +4 more
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Cyclophilin B Deficiency Causes Abnormal Dentin Collagen Matrix

Journal of Proteome Research, 2017
Cyclophilin B (CypB) is an endoplasmic reticulum-resident protein that regulates collagen folding, and also contributes to prolyl 3-hydroxylation (P3H) and lysine (Lys) hydroxylation of collagen. In this study, we characterized dentin type I collagen in CypB null (KO) mice, a model of recessive osteogenesis imperfecta type IX, and compared to those of ...
Masahiko, Terajima, Yuki, Taga, Wayne A, Cabral, Masako, Nagasawa, Noriko, Sumida, Shunji, Hattori, Joan C, Marini, Mitsuo, Yamauchi   +7 more
openaire   +2 more sources

Evidence that human milk isolated cyclophilin B corresponds to a truncated form

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1996
Cyclophilin B (CyPB) is a member of the cyclophilin family (cyclosporin A-binding proteins) with specific N- and C-terminal extensions. In contrast to cyclophilin A, CyPB owns a signal sequence leading to its translocation in the endoplasmic reticulum. CyPB was reported to be present in human blood and milk, suggesting it is secreted. For this purpose,
C, Mariller, F, Allain, M, Kouach, G, Spik   +3 more
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Calcium signalling in T cells stimulated by a cyclophilin B-binding protein

Nature, 1994
The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin, cyclosporin A binds and inactivates the key signalling intermediate calcineurin. To identify potential cellular homologues of cyclosporin A that might regulate calcium signalling,
R J, Bram, G R, Crabtree
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[787] THE REDUCTION OF BOTH CYCLOPHILIN B AND HCV-RNA BY THE CYCLOPHILIN INHIBITOR DEBIO-025 CONFIRMS THE IMPORTANCE OF CYCLOPHILIN B FOR HCV REPLICATION IN MAN

Journal of Hepatology, 2007
P. Gallav, R. Flisiak, A. Horban, C. Aeschlimann, J.M. Dutnont, H. Porchet, P. Scalfaro, R. Crabbe   +7 more
openaire   +1 more source

The Role of Cyclophilin B in Hepatocellular Carcinoma Development

Free Radical Biology and Medicine, 2010
Yeonghwan Kim, Sung Soo Kim
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Cyclophilin A/CD147 Interaction: A Promising Target for Anticancer Therapy

International Journal of Molecular Sciences, 2022
Hye Jin Jung, Jang Mi Han, Jung Hye Jin
exaly  

Delicate regulation of IL-1β-mediated inflammation by cyclophilin A

Cell Reports, 2022
Wenjun Liu, Wei Liu, Lei Sun
exaly  

Osteogenesis Imperfecta, Normal Collagen Folding, and Lack of Cyclophilin B

New England Journal of Medicine, 2010
van Dijk, F.S., Cobben, J.M., Pals, G.
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