Results 91 to 100 of about 4,905 (211)

Homo-dimerization and ligand binding by the leucine-rich repeat domain at RHG1/RFS2 underlying resistance to two soybean pathogens [PDF]

, 2013
BACKGROUND: The protein encoded by GmRLK18-1 (Glyma_18_02680 on chromosome 18) was a receptor like kinase (RLK) encoded within the soybean (Glycine max L. Merr.) Rhg1/Rfs2 locus.
Abhishek Goil, Ahmed J Afzal, Ali Srour, Ayan Malakar, David A Lightfoot, Navneet Dogra, Punit Kohli, Ram Samudrala, Sheeja Vasudaven, Tianyun Liu   +9 more
core   +2 more sources

Cyclophilin inhibitors as antiviral agents

Bioorganic & Medicinal Chemistry Letters, 2013
Cyclophilins (Cyps) are ubiquitous proteins that effect the cis-trans isomerization of Pro amide bonds, and are thus crucial to protein folding. CypA is the most prevalent of the ~19 human Cyps, and plays a crucial role in viral infectivity, most notably for HIV-1 and HCV.
Peel, Michael, Scribner, Andrew
openaire   +2 more sources

The GmGT‐2F, a trihelix transcription factor, regulates seed oil content by directly activating GmAGAL transcription in soybean

Journal of Integrative Plant Biology, EarlyView.
In soybean, the trihelix transcription factor GmGT‐2F positively regulates the expression of the α‐galactosidase gene GmAGAL, thereby modulating seed oil content. The cyclophilin GmCYP2 interacts with GmGT‐2F and suppresses GmAGAL activation. Haplotype diversity analysis of GmGT‐2F, GmCYP2, and GmAGAL identified favorable haplotype combinations ...
Shuangzhe Li, Yifan Cui, Yang Liu, Mingliang Yang, Xiaoxia Wu, Qingshan Chen, Ying Zhao   +6 more
wiley   +1 more source

Molecular Characterization of Cyclophilin Protein Gene in Skin Normal Microflora: Malassezia furfur [PDF]

Iranian Journal of Public Health, 2009
Background: Malassezia are dimorphic, lipid-dependent yeasts, which are responsible for causing several cutaneous and sys­temic conditions. Although cyclophilins (CyPs) are highly conserved cytosolic proteins that catalyze the peptidyl-prolyl cis-trans ...
M Moazeni , F Noorbakhsh, F Zaini , P Kordbacheh , J Hashemi , B Mousavi , L Andonian , S Rezaie   +7 more
doaj   +1 more source

Cyclophilin A and viral infections

Biochemical and Biophysical Research Communications, 2012
Cyclophilin A (CyPA) is a peptidyl-prolyl cis/trans isomerase originally identified as the target of the immunosuppressive drug cyclosporine A. A number of reports have demonstrated that CyPA plays a critical role in the successful replication of viruses such as human immunodeficiency virus (HIV), hepatitis C virus (HCV), hepatitis B virus (HBV), etc ...
Zhou, Daijun, Mei, Qiang, Li, Jintao, He, Haiyang   +3 more
openaire   +2 more sources

Novel roles of sulfur metabolism in stress‐controlled stomata aperture regulation

New Phytologist, EarlyView.
Summary Stomatal closure allows plants to conserve water by reducing transpiration during drought. Surprisingly, the assimilation of the macronutrient sulfur is intimately connected to the drought stress response. This Tansley insight will only briefly touch on the general impact of sulfate assimilation on the production of drought‐response metabolites.
Sheng‐Kai Sun, Rüdiger Hell, Markus Wirtz   +2 more
wiley   +1 more source

Not just fat : investigating the proteome of cetacean blubber tissue [PDF]

, 2018
Mammalian adipose tissue is increasingly being recognized as an endocrine organ involved in the regulation of a number of metabolic processes and pathways.
Botting, Catherine Helen, Brownlow, Andrew, Hall, Ailsa Jane, Kershaw, Joanna Louise   +3 more
core   +2 more sources

Feline coronavirus replication is affected by both cyclophilin A and cyclophilin B

Journal of General Virology, 2017
Feline coronavirus (FCoV) causes the fatal disease feline infectious peritonitis, which is currently incurable by drug treatment, and no effective vaccines are available. Cyclosporin A (CsA), a cyclophilin (Cyp) inhibitor, inhibits the replication of FCoV in vitro and in vivo as well as the replication of human and animal coronaviruses.
Tanaka, Yoshikazu, Sato, Yuka, Sasaki, Takashi   +2 more
openaire   +2 more sources

Cyclophilin A‐mediated cis/trans isomerization modulates RIN4 to control intracellular rhizobial infection in legumes

New Phytologist, EarlyView.
Summary In most legume‐rhizobium symbioses, rhizobial colonization occurs through host‐derived intracellular infection threads, which enable rhizobial recruitment while presumably modulating the host immune system to prevent rejection. To investigate post‐translational regulation of immune responses during rhizobial infection, we focused on Cyclophilin
Takashi Goto, Kasper Røjkjær Andersen, Masaru Bamba, Shusei Sato, Masayuki Sugawara, Kiwamu Minamisawa, Masayoshi Kawaguchi, Jens Stougaard, Yasuyuki Kawaharada   +8 more
wiley   +1 more source

The distribution of different classes of nuclear localization signals (NLSs) in diverse organisms and the utilization of the minor NLS-binding site in plant nuclear import factor importin-α [PDF]

, 2013
The specific recognition between the import receptor importin-α and the nuclear localization signals (NLSs) is crucial to ensure the selective transport of cargoes into the nucleus.
Bostjan Kobe, Chelsky D, Chiung-Wen Chang, Mikael Boden, Rafael Miguez Couñago, Simon J. Williams   +5 more
core   +1 more source