Results 121 to 130 of about 4,905 (211)

Versatility of Cyclophilins in Plant Growth and Survival: A Case Study in Arabidopsis

Biomolecules, 2019
Cyclophilins (CYPs) belong to a peptidyl-prolyl cis-trans isomerase family, and were first characterized in mammals as a target of an immunosuppressive drug, cyclosporin A, preventing proinflammatory cytokine production.
Izailda Barbosa dos Santos, Sang-Wook Park   +1 more
doaj   +1 more source

Novel inhibitors of the calcineurin/NFATc hub - alternatives to CsA and FK506? [PDF]

, 2009
The drugs cyclosporine A (CsA) and tacrolimus (FK506) revolutionized organ transplantation. Both compounds are still widely used in the clinic as well as for basic research, even though they have dramatic side effects and modulate other pathways than ...
Matthias Sieber, Ria Baumgrass, CB Klee, GR Crabtree, CB Klee, JO Liu, JO Liu, M Morioka, A Rao, E Serfling, PG Hogan, F Macian, J Yang, TD Batiuk, IA Graef, OF Bueno, H Okamura, C Luo, J Zhu, CR Beals, H Okamura, J Liu, J Aramburu, FJ Garcia-Cozar, S Martinez-Martinez, A Rodriguez, H Li, J Roy, B Frantz, T Sugimoto, RE Dolmetsch, H Alzuherri, JA Valdes, L Guo, Q Liu, J Ninomiya-Tsuji, JP Pearl, DL Jones, AL Taylor, MM El-Batawy, C Brandt, F Rusnak, R Sugiura, JF Borel, RY Calne, TE Starzl, T Kino, TE Starzl, J Liu, SL Schreiber, S Barik, CB Kang, JP Griffith, CR Kissinger, Q Huai, L Jin, SK Swanson, M Yin, RE Handschumacher, JJ Siekierka, MW Harding, K Kalli, Y Aoki, NM Steffan, E Oetjen, R Marienfeld, S Meyer, P Nickel, M Naesens, A Kiani, Y Zhang, PL Durette, NH Sigal, PA Nelson, R Baumgrass, JD Aebi, L Aspeslet, T Birsan, WP Maksymowych, P Naidoo, FJ Dumont, A Klettner, J Liu, M Grassberger, LB Peterson, FJ Dumont, SL Schreiber, AW Thomson, JM Campistol, TL Born, BL Martin, SG Stewart, DC Weiser, A Enz, KL Fakata, H Wang, H Lei, S Lee, M Humar, M Humar, T Loop, C Correa-Sales, Y Baba, Y Baba, NJ Carruthers, WB Xu, B Weissenmayer, MS Gomez, BZ Yu, RC Adlakha, A Gualberto, GM Brill, MC Mulero, AA Borisy, M Sieber, MH Roehrl, S Kang, SW Djuric, Y Chen, JM Trevillyan, J Ishikawa, C Zitt, R Takezawa, T Yoshino, K Ohga, N Steinckwich, T Birsan, LM Nilsson, RI Jabr, R Lindstedt, G Mistrello, S Campo, ED Hogestatt, FJ Caballero, J Roman, E Bailon, M Aceves, P Proksch, SJ O'Keefe, L Vega Lde, K Mousavizadeh, N Venkatesh, Y Baine, SD Yang, F Rusnak, C Aussel, EJ Jung, N Marquez, S Ansorge, K Natarajan, S Kuromitsu, WF Michne, CM Murray, NS Burres, SI Lee, N Marquez, HZ Jin, PV Kiem, NT Dat, NT Dat, XF Cai, XF Cai, XF Cai, NT Dat, IS Lee, JK Sagoo, Y Hashimoto, BA Perrino, BA Perrino, H Terada, SZ Husain, S Feske, J Aramburu, H Noguchi, ML Dell'Acqua, MM Lai, L Sun, CD Harris, B Chan, A Aubareda, S Martinez-Martinez, S Mehta, S Park, J Liu, H Jang, TJ Kingsbury, RB Vega, M Boncristiano, B Gebert, MS Sundrud, X Sewald, JE Miskin, AG Granja, S Matsuda, AG Granja, JE Miskin, JH Tatlock, C Bialojan, DA Fruman, PJ Sinclair, R Baumgrass   +200 more
core   +1 more source

Cyclosporine inhibits a direct interaction between cyclophilins and hepatitis C NS5A.

PLoS ONE, 2010
BackgroundHepatitis C Virus (HCV) infection is a leading indication for liver transplantation. HCV infection reoccurs almost universally post transplant, decreasing both graft longevity and patient survival.
Fiona Fernandes, Israr-ul H Ansari, Rob Striker   +2 more
doaj   +1 more source

Peptidylprolyl Isomerases as In Vivo Carriers for Drugs That Target Various Intracellular Entities

Biomolecules, 2017
Analyses of sequences and structures of the cyclosporine A (CsA)-binding proteins (cyclophilins) and the immunosuppressive macrolide FK506-binding proteins (FKBPs) have revealed that they exhibit peculiar spatial distributions of charges, their overall ...
Andrzej Galat
doaj   +1 more source

SIV replication in human cells

Frontiers in Microbiology, 2012
Current human immunodeficiency virus type 1 (HIV-1) pandemic is believed to originate from cross-species transmission of simian immunodeficiency virus (SIV) into human population.
Hiroaki eTakeuchi, Ryuta eSakuma
doaj   +1 more source

Epstein-Barr virus, infectious mononucleosis, and posttransplant lymphoproliferative disorders. [PDF]

, 1994
PTLD may be considered as an "opportunistic cancer" in which the immunodeficiency state of the host plays a key role in fostering the environment necessary for abnormal lymphoproliferation.
Nalesnik, MA, Starzl, TE
core  

Transmembrane segment proteases [PDF]

, 2018
Summary: Transmembrane segment proteases comprise a novel class of proteases that cleave substrates within hydrophobic membrane-spanning segments. They cleave in parts of proteins that upon first glance should be protected by the hydrophobic environment ...
Martoglio, B.
core  

Extracellular cyclophilins in health and disease

Biochimica et Biophysica Acta (BBA) - General Subjects, 2015
Extracellular cyclophilins (eCyPs) are pro-inflammatory factors implicated in pathogenesis of a number of inflammatory diseases. Most pathogenic activities of eCyPs are related to their chemotactic action towards leukocytes, which is mediated by eCyP receptor on target cells, CD147, and involves peptidyl-prolyl cis-trans isomerase activity of ...
openaire   +2 more sources

Calmodulin, Cyclophilin, and Cyclosporin A [PDF]

Science, 1986
W N, Hait, M W, Harding, R E, Handschumacher   +2 more
openaire   +2 more sources

Cyclophilin [PDF]

Science-Business eXchange, 2010
openaire   +1 more source