Identification of ER-000444793, a Cyclophilin D-independent inhibitor of mitochondrial permeability transition, using a high-throughput screen in cryopreserved mitochondria [PDF]
, 2016 Growing evidence suggests persistent mitochondrial permeability transition pore (mPTP) opening is a key pathophysiological event in cell death underlying a variety of diseases.
Briston, T +12 more
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Isoform-Specific Inhibition of Cyclophilins [PDF]
Biochemistry, 2009 Cyclophilins belong to the enzyme class of peptidyl prolyl cis-trans isomerases which catalyze the cis-trans isomerization of prolyl bonds in peptides and proteins in different folding states. Cyclophilins have been shown to be involved in a multitude of cellular functions like cell growth, proliferation, and motility.
Sebastian, Daum +9 more
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Suppression of Coronavirus Replication by Cyclophilin Inhibitors
Viruses, 2013 Coronaviruses infect a variety of mammalian and avian species and cause serious diseases in humans, cats, mice, and birds in the form of severe acute respiratory syndrome (SARS), feline infectious peritonitis (FIP), mouse hepatitis, and avian infectious ...
Takashi Sasaki +2 more
doaj +1 more source
Frontiers in Plant Science, 2022 Peptidyl-prolyl cis-trans isomerases (PPIases) are ubiquitous proteins which are essential for cis-trans isomerisation of peptide bonds preceding the proline residue.
Anantika Suri +4 more
doaj +1 more source
Analysis of barley leaf epidermis and extrahaustorial proteomes during powdery mildew infection reveals that the PR5 thaumatin-like protein TLP5 is required for susceptibility towards Blumeria graminis f. sp. hordei [PDF]
, 2019 Powdery mildews are biotrophic pathogens causing fungal diseases in many economically important crops, including cereals, which are affected by Blumeria graminis.
Aguilar +83 more
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Cyclophilin D Modulates Mitochondrial Acetylome [PDF]
Circulation Research, 2013 Rationale: Mice lacking cyclophilin D (CypD −/− ), a mitochondrial chaperone protein, have altered cardiac metabolism. As acetylation has been shown to regulate metabolism, we tested whether changes in protein acetylation might play a role in these metabolic
Tiffany Tuyen M, Nguyen +9 more
openaire +2 more sources
In silico analysis of the cyclophilin repertoire of apicomplexan parasites
Parasites & Vectors, 2009 Background Cyclophilins (Cyps) are peptidyl cis/trans isomerases implicated in diverse processes such as protein folding, signal transduction, and RNA processing.
von Samson-Himmelstjerna Georg +2 more
doaj +1 more source
Increased susceptibility of striatal mitochondria to calcium-induced permeability transition [PDF]
, 2003 Mitochondria were simultaneously isolated from striatum and cortex of adult rats and compared in functional assays for their sensitivity to calcium activation of the permeability transition.
Brustovetsky, N +5 more
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An endoplasmic reticulum-specific cyclophilin. [PDF]
Molecular and Cellular Biology, 1991 Cyclophilin is a ubiquitously expressed cytosolic peptidyl-prolyl cis-trans isomerase that is inhibited by the immunosuppressive drug cyclosporin A. A degenerate oligonucleotide based on a conserved cyclophilin sequence was used to isolate cDNA clones representing a ubiquitously expressed mRNA from mice and humans.
K W, Hasel +3 more
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Inhibition of cyclophilins alters lipid trafficking and blocks hepatitis C virus secretion
Virology Journal, 2011 Host cyclophilin (cyp) inhibitors, such as NIM811, efficiently inhibit replication of hepatitis C virus (HCV) and have shown significant promise in recent clinical trials for the treatment of chronic HCV. It is therefore important to fully understand the
Compton Teresa +3 more
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