Gain-of-Sensitivity Mutations in a Trim5-Resistant Primary Isolate of Pathogenic SIV Identify Two Independent Conserved Determinants of Trim5α Specificity [PDF]
, 2013 Retroviral capsid recognition by Trim5 blocks productive infection. Rhesus macaques harbor three functionally distinct Trim5 alleles: Trim5αQ, Trim5αTFP and Trim5CypA.
Johnson, Welkin E. +5 more
core +3 more sources
Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review
British Journal of Pharmacology, EarlyView.Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos +16 more
wiley +1 more source
Overoxidation of chloroplast 2-Cys peroxiredoxins: balancing toxic and signaling activities of hydrogen peroxide [PDF]
, 2013 Photosynthesis, the primary source of biomass and oxygen into the biosphere, involves the transport of electrons in the presence of oxygen and, therefore, chloroplasts constitute an important source of reactive oxygen species, including hydrogen peroxide.
Armario Nájera, María Victoria +8 more
core +4 more sources
The competitive interplay of 12‐oxophytodienoic acid (OPDA), protein thiols, and glutathione
The FEBS Journal, EarlyView.12‐Oxophytodienoic acid (OPDA) is a phytohormone involved in plant growth and stress defense. Due to its cyclopentenone moiety, OPDA can form Michael adducts with thiol‐containing compounds such as glutathione and cysteine residues of proteins, resulting in alterations of the cellular redox regulatory network.
Madita Knieper +8 more
wiley +1 more source
Monocarboxylate transporters 1 and 4 are associated with CD147 in cervical carcinoma [PDF]
, 2009 Due to the highly glycolytic metabolism of solid tumours, there is an increased acid production, however, cells are able to maintain physiological pH through plasma membrane efflux of the accumulating protons.
Baltazar, Fátima +8 more
core +2 more sources
The FEBS Journal, EarlyView.Genetic rearrangements resulting in the expression of KMT2A fusion alleles can lead to dramatic transcriptional disturbances that contribute to the onset of acute leukaemias. Fortunately, menin inhibition has emerged as a promising new class of targeted therapy.
Lydia Elaine Roets +2 more
wiley +1 more source
Stereo views of cocrystal structures of cyclophilins with cyclophilin inhibitors.pdf
, 2016 Cocrystal structures (stereo views of sections of the electron density maps) of cyclophilin D complexed with different compounds from a new family of nonpeptidic, small-molecule cyclophilin ...
Jean-Michel Pawlotsky +12 more
openaire +1 more source
The impact of accumulating immune adaptation in circulating strains of HIV‐1
HIV Medicine, EarlyView.Abstract Background Mutations in human immunodeficiency virus type 1 (HIV‐1) enable the virus to evade recognition and killing by human leucocyte antigen (HLA)‐restricted T cells. These viral adaptations are specific to the HLA type of individuals and are therefore evident as HLA allele‐HIV sequence associations at the population level. Most studies of
Marwah Al‐kaabi +7 more
wiley +1 more source
Expression and prognostic relevance of Cyclophilin A and matrix metalloproteinase 9 in esophageal squamous cell carcinoma [PDF]
, 2013 AIMS: To guide clinicians in selecting treatment options for esophageal squamous cell carcinoma (ESCC) patients, reliable markers predictive of clinical outcome are desirable.
Danfeng Dong +4 more
core +1 more source
Piscirickettsiosis in Farmed Turbot, Scophthalmus maximus
Journal of Fish Diseases, EarlyView.ABSTRACT Piscirickettsia salmonis is a well‐established intracellular pathogen of farmed Atlantic salmon around the world. The bacterium has also been detected from a number of other hosts including lumpfish (Cyclopterus lumpus), seabass (Dicentrarchus labrax) and rainbow trout (Oncorhynchus mykiss).
Hanne K. Nilsen +9 more
wiley +1 more source