Results 41 to 50 of about 10,845 (167)

Design, Synthesis, and Antimicrobial Activity of Amide Derivatives Containing Cyclopropane

Molecules
As an important small organic molecule, cyclopropane is widely used in drug design. In this paper, fifty-three amide derivatives containing cyclopropane were designed and synthesized by introducing amide groups and aryl groups into cyclopropane through ...
Dongdong Chen, Yu Cheng, Lele Shi, Xueting Gao, Yuhang Huang, Zhenting Du   +5 more
doaj   +1 more source

Simmons–Smith Cyclopropanation: A Multifaceted Synthetic Protocol toward the Synthesis of Natural Products and Drugs: A Review

Molecules, 2023
Simmons–Smith cyclopropanation is a widely used reaction in organic synthesis for stereospecific conversion of alkenes into cyclopropane. The utility of this reaction can be realized by the fact that the cyclopropane motif is a privileged synthetic ...
Ramsha Munir, Ameer Fawad Zahoor, Sadia Javed, Bushra Parveen, Asim Mansha, Ahmad Irfan, Samreen Gul Khan, Ali Irfan, Katarzyna Kotwica-Mojzych, Mariusz Mojzych   +9 more
doaj   +1 more source

Charge State Influence on Stability and Isomerism in Dehydrogenated PAHs: Insights from Anthracene, Acridine, and Phenazine

ChemPhysChem, Volume 26, Issue 6, March 15, 2025.
The ionization of anthracene, acridine, and phenazine has been explored, along with the removal of one and two hydrogen atoms, to provide valuable information for astrochemists and to understand the behavior of the resulting structures and their electronic reorganization. Abstract In this study, we systematically explored the stability and isomerism of
Khaldia Zghida, Farouk Hamza Reguig, Manuel Alcamí, Al Mokhtar Lamsabhi   +3 more
wiley   +1 more source

The Effect of the Gem‐Dimethyl Unit in the Gold‐Catalyzed Cycloisomerization of Aliphatic 1‐Bromoalkynes

European Journal of Organic Chemistry, EarlyView.
The conformational effect of the gem‐dimethyl motif and its isostere cyclopropane unit in the gold‐catalyzed cycloisomerization of aliphatic 1‐bromoalkynes has been studied. An unexpected inhibitory effect of the cyclopropane ring has been observed.
Rubén Miguélez, Omar Arto, Hanna Siera, Isabel Merino, Gebhard Haberhauer, Pablo Barrio   +5 more
wiley   +1 more source

(Poly)Borylated Species as Modern Reactive Groups toward Unusual Synthetic Applications

Angewandte Chemie, Volume 138, Issue 10, 2 March 2026.
In this review, we spotlight recent breakthroughs in α‐polyboron‐substituted carbon‐centered intermediates (carbanion, carbocation, radical, and carbene) and polyborylated alkenes. By bridging fundamental reactivity with the application potential of these extraordinary species, we hope this review will serve as a roadmap for harnessing these unique ...
Nadim Eghbarieh, Nicole Hanania, Pinaki Nad, Tipu Alam, Tamir Kish, Ahmad Masarwa   +5 more
wiley   +2 more sources

Crystal structures of two bicyclo[5.1.0]octanes: potassium trans-bicyclo[5.1.0]octane-4-carboxylate monohydrate and cis-bicyclo[5.1.0]octan-4-yl 4-bromobenzenesulfonate

Acta Crystallographica Section E: Crystallographic Communications, 2017
The crystal structures of the trans-fused compound potassium trans-bicyclo[5.1.0]octane-4-carboxylate monohydrate, K+·C9H13O2−·H2O, (I), and of cis-bicyclo[5.1.0]octan-4-yl 4-bromobenzenesulfonate, C14H17BrO3S, (II), have been determined.
Peter W. R. Corfield, Richard A. Kershaw
doaj   +1 more source

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source

PCA‐Based Database Mining Enables the Discovery of Bacterial Carbene Transferases for Stereodivergent Cyclopropanation

Angewandte Chemie, Volume 138, Issue 10, 2 March 2026.
Database mining using principal component analysis (PCA)‐based clustering enabled discovery of bacterial enzymes capable of catalyzing stereodivergent cyclopropanation of styrene. Statistical analyses of sequence data further revealed characteristic structural properties of these enzymes, highlighting the potential of the bioinformatics tools for ...
Shunsuke Kato, Koki Takeuchi, Kohei Umeda, Hisashi Kudo, Tomohisa Hasunuma, Takashi Hayashi   +5 more
wiley   +2 more sources

Determination of Cyclopropane Fatty Acids in Food of Animal Origin by 1H NMR

Journal of Analytical Methods in Chemistry, 2018
Cyclopropane fatty acids (CPFAs) are unusual fatty acids of microbial origin, recently detected in milk and dairy products. CPFAs have been demonstrated to be interesting molecular markers for authentication of dairy products obtained without ensiled ...
Veronica Lolli, Angela Marseglia, Gerardo Palla, Emanuela Zanardi, Augusta Caligiani   +4 more
doaj   +1 more source

Asymmetric and Regiospecific Synthesis of Isotopically Labelled Cyclopropane Fatty Acid (9R,10S)-Dihydrosterculic Acid: Overcoming Spontaneous Protonation During Lithium-Sulfoxide Exchange­

SynOpen, 2018
The total synthesis of isotopically labelled (9R,10S)-dihydro­sterculic acid, a usual cyclopropane fatty acid with biologically relevant toxicity upon desaturation in vivo, is reported. A diastereoselective Corey­–Chaykovsky reaction was employed to form
Samuel W. J. Shields, Peter H. Buist, Jeffrey M. Manthorpe   +2 more
doaj   +1 more source