Results 31 to 40 of about 82,661 (227)

FK 506 ameliorates the hepatic injury associated with ischemia and reperfusion in rats [PDF]

, 1991
The effect of FK 506 on regeneration of the liver was studied in rats after a two‐thirds partial hepatectomy after 60 min of ischemia of the unresected liver. The animals were divided into three distinct groups of 10 rats each.
Babaeva, Bergmeyer, Borel, Craddock, Craddock, Demetris, Farber, Flye, Francavilla, Francavilla, Gonzalez, Goto, Guzek, Higgins, Kahn, Kawano, Kim, Kim, Marubayashi, Marubayashi, Mazzaferro, Mazzaferro, Meer, Metzger, Miyahara, Ohhori, Sakai, Sakai, Sakai, Sobotka, Starzl, Stromski, Takahashi, Weeds, Yushimira   +34 more
core   +1 more source

Effect of Terbinafine on the Pharmacokinetics of Cyclosporin in Humans [PDF]

, 1994
Cyclosporin is largely metabolized by hepatic cytochrome P450 enzymes, and azole drugs that inhibit cytochrome P450 may precipitate cyclosporin toxicity. The allylamine terbinafine binds to a small subfraction of hepatic cytochrome P450 in type I fashion,
Blankers, Matthijs, Busschbach, Jan J.V., Dekker, Jack J.M., Kikkert, Martijn J., Laurenssen, Elisabeth M.P., Luyten, Patrick, Peen, Jaap, Soons, Mirjam B.J., van Broekhuyzen, Anna J., van Dam, Anne Marie, Westra, Dieuwertje   +10 more
core   +2 more sources

Preferential Solvation of Cyclosporin in Aqueous Mixtures of Some Polymeric Cosolvents [PDF]

ImmunoAnalysis
Background: Cyclosporin is a cyclic peptide-drug used as immunosuppressant for the prophylaxisof transplant rejection whose physicochemical properties in mixed aqueous solvent systems isstill not well understood.
María Ángeles Peña, Olga E. García-Serna, Darío A. Tinjacá, Daniel R. Delgado, Fleming Martínez   +4 more
doaj   +1 more source

Analysis of the Treatment Efficacy in Late Diagnosis of Alport Syndrome in a Child: Clinical Case

Вопросы современной педиатрии, 2023
Background. Alport syndrome is a systemic, hereditary, progressive disease characterized by ultrastructural changes in the glomerular basement membrane caused by pathogenic variants of type IV collagen genes.
Svetlana Ya. Volgina, Nailya A. Solovyeva, Galina A. Kulakova, Elena A. Kurmayeva, Liliya I. Mukhametdinova, Elina L. Rashitova   +5 more
doaj   +1 more source

Liquid Crystalline Inverted Lipid Phases and Reverse Micelles in Drug Delivery: From Molecular Design to Therapeutic Potential

Advanced Functional Materials, EarlyView.
Liquid crystalline inverted lipid phases and reverse micelles are self‐assembled lipid nanostructures that enhance the solubility, stability, and delivery of diverse therapeutics. This review integrates their physicochemical principles, formulation strategies, drug loading mechanisms, and biomedical applications, highlighting their growing ...
Numan Eczacioglu, Mulazim Hussain Asim, Soheil Haddadzadegan, Andreas Bernkop‐Schnürch   +3 more
wiley   +1 more source

Immunomodulation stimulates the innervation of engineered tooth organ [PDF]

, 2014
The sensory innervation of the dental mesenchyme is essential for tooth function and protection. Sensory innervation of the dental pulp is mediated by axons originating from the trigeminal ganglia and is strictly regulated in time. Teeth can develop from
Bécavin, Thibault, Keller, Laetitia, Kuchler-Bopp, Sabine, Kökten, Tunay, Lesot, Hervé, Weikert, Jean-Luc   +5 more
core   +5 more sources

What to do when traditional rescue therapies fail in acute severe ulcerative colitis [PDF]

Intestinal Research
Acute severe ulcerative colitis (ASUC) is a medical emergency that affects approximately 25% of patients with ulcerative colitis at some point in time in their lives. Outcomes of ASUC are highly variable.
Christopher F. D. Li Wai Suen, Matthew C. Choy, Peter De Cruz   +2 more
doaj   +1 more source

SEVERE FORM OF ATOPIC DERMATITIS AS A THERAPEUTIC CHALLENGE

Slovenska pediatrija, 2022
Atopic dermatitis (AD) is the most common chronic inflammatory skin disease of childhood. The disease is characterized by recurrent eczematoid itchy skin lesions caused by a combination of genetic predisposition and environmental factors (1-2).
Janja Golobič, Gašper Markelj
doaj   +1 more source

CypD Dependent mPTP Opening Is Crucial for Oxidized Mitochondrial DNA Release in Ferroptosis

Advanced Science, EarlyView.
Ferroptosis is driven by mitochondrial permeability transition pore (mPTP) opening, which induces mitochondrial swelling and releases oxidized mitochondrial DNA. The released mtDNA activates cGAS–STING signaling, promotes ferritinophagy, and amplifies ferroptotic cell death. Disruption of mtDNA repair sensitizes tumors to ferroptosis in vivo, revealing
Hong Zhou, Wan Fu, Shizuo Liu, Zili Zhang, Hanyan Luo, Qing Zhong   +5 more
wiley   +1 more source

RaPID Selection of Backbone Macrocyclic Peptides Targeting Akt2

Angewandte Chemie International Edition, EarlyView.
Backbone macrocyclic peptide library (BMP) library was screened against Akt2 via RaPID to discover potent BMPPakti‐3 (IC50 = 34 nM). ABSTRACT Backbone‐cyclic peptides (BMPs) are an attractive class of molecules appeared in diverse natural bioactive products. However, mRNA display technology coupled with ribosomal synthesis is intrinsically inapplicable
Koki Shinbara, Ekishin Yanagi, Ayaka Aizawa, Takayuki Katoh, Hiroaki Suga   +4 more
wiley   +1 more source