Increased susceptibility of striatal mitochondria to calcium-induced permeability transition [PDF]
, 2003 Mitochondria were simultaneously isolated from striatum and cortex of adult rats and compared in functional assays for their sensitivity to calcium activation of the permeability transition.
Brustovetsky, N +5 more
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Preferential Solvation of Cyclosporin in Aqueous Mixtures of Some Polymeric Cosolvents [PDF]
ImmunoAnalysisBackground: Cyclosporin is a cyclic peptide-drug used as immunosuppressant for the prophylaxisof transplant rejection whose physicochemical properties in mixed aqueous solvent systems isstill not well understood.
María Ángeles Peña +4 more
doaj +1 more source
Cadaveric renal transplantation under cyclosporine-steroid therapy [PDF]
, 1983 Ninety-seven cadaveric renal transplants were performed upon 96 patients during 1981. The one year patient mortality was 2.1 per cent. Seventy of the recipients were undergoing trasplantation for the first time.
Hakala, TR +4 more
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Head & Face Medicine, 2006 Background Drug-induced gingival overgrowth is a frequent adverse effect associated principally with administration of the immunosuppressive drug cyclosporin A and also certain antiepileptic and antihypertensive drugs.
Özdemir B Handan +3 more
doaj +1 more source
Frontiers in Oncology, 2020 Anemia associated with Immune checkpoint inhibitor (ICI) is usually hemolytic and regenerative. Cases of non-regenerative pure red cell aplasia are rare, and typically improve upon drug discontinuation and after corticotherapy. We herein report a case of
Alexandre Gérard +9 more
doaj +1 more source
Assay for free secretory component and methods for monitoring organ rejection [PDF]
, 1996 Methods of monitoring and detecting the early onset of organ injury incident rejection of a organ rejection in an animal are disclosed. The described methods are capable of distinguishing organ rejection injury from other organ tissue damage in the ...
Goldblum, Randall M. +1 more
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Combined Cyclosporin A and Hypothermia Treatment Inhibits Activation of BV-2 Microglia but Induces an Inflammatory Response in an Ischemia/Reperfusion Hippocampal Slice Culture Model [PDF]
, 2019 Introduction: Hypothermia attenuates cerebral ischemia-induced neuronal cell death associated with neuroinflammation. The calcineurin inhibitor cyclosporin A (CsA) has been shown to be neuroprotective by minimizing activation of inflammatory pathways.
Berger, Felix +5 more
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Protein kinase C modulates the activity of a cloned gamma-aminobutyric acid transporter expressed in Xenopus oocytes via regulated subcellular redistribution of the transporter [PDF]
, 1994 We report that activators and inhibitors of protein kinase C (PKC) and protein phosphatases regulate the activity of a cloned rat brain gamma- aminobutyric acid (GABA) transporter (GAT1) expressed in Xenopus oocytes.
Brecha, Nicholas +4 more
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Treatment of atopic dermatitis with cyclosporin A: a case report
Przegląd Dermatologiczny, 2017 Introduction . Despite the progress that has been made in the therapy of atopic dermatitis in recent years, cyclosporin A remains the first-line treatment of severe forms of the disease. Objective.
Karolina Kaaz, Adam Reich
doaj +1 more source
, 2011 In this work we monitor the catalytic mechanism of P-glycoprotein (Pgp) using single-molecule fluorescence resonance energy transfer (FRET). Pgp, a member of the ATP binding cassette family of transport proteins, is found in the plasma membrane of animal
Boersch, Michael +4 more
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