Results 41 to 50 of about 204,688 (384)

Changes in the blood cyclosporine level after switching from voriconazole to isavuconazole in a patient with aplastic anemia: insights from physiologically based pharmacokinetic model simulation and the Adverse Event Reporting System database study

Frontiers in Microbiology
IntroductionIsavuconazole, a broad-spectrum triazole approved by the United States Food and Drug Administration (FDA) in 2015, moderately inhibits cytochrome P450 3A4.
Chihiro Shiraishi, Chihiro Shiraishi, Hideo Kato, Hideo Kato, Kazuko Ino, Takuya Iwamoto, Takuya Iwamoto   +6 more
doaj   +1 more source

Medical Management of Cyclosporine-Induced Gingival Overgrowth Using Oral Azithromycin in Six Dogs

Veterinary Sciences, 2015
Gingival overgrowth is an uncommon adverse effect of cyclosporine administration in veterinary species. In people, gingival overgrowth is a common complication of cyclosporine administration for immunosuppression, generally following transplant ...
Alison Diesel, Karen Moriello
doaj   +1 more source

Intramatricial injections for nail psoriasis: An open-label comparative study of triamcinolone, methotrexate, and cyclosporine

Indian Journal of Dermatology, Venereology and Leprology, 2018
Background: One of the most effective options available for treating psoriatic fingernails is intramatricial injection of triamcinolone acetonide. Efficacies of intramatricial methotrexate and cyclosporine have not been comparatively evaluated to date ...
Jyotisterna Mittal, B. Mahajan
semanticscholar   +1 more source

Infliximab versus Cyclosporine Treatment for Severe Corticosteroid-Refractory Ulcerative Colitis: A Korean, Retrospective, Single Center Study

Gut and Liver, 2015
Background/AimsIn patients with corticosteroid-refractory ulcerative colitis (UC), cyclosporine or infliximab may be added to the treatment regimen to induce remission.
doaj   +1 more source

Solubilization of cyclosporin A [PDF]

AAPS PharmSciTech, 2001
This study investigated the solubilization of cyclosporin A (CsA), a neutral undecapeptide, by cosolvency, micellization, and complexation. Cosolvents (ethanol, propylene glycol, polyethylene glycol, tetrahydrofurfuryl alcohol polyethyleneglycol ether, and glycerin), surfactants (polyoxyethylene sorbitan monooleate [(Tween 80)], polyoxyethylene ...
Yingqing Ran, Samuel H. Yalkowsky, Qing Xu, Luwei Zhao   +3 more
openaire   +3 more sources

Effects of the calcineurin inhibitors cyclosporine and tacrolimus on bone metabolism in rats.

Biomedical research, 2018
Immunosuppressive therapy is considered as one of the factors inducing to the onset of osteoporosis after organ transplantation. Chronic immunosuppressive therapy after transplantation is required for organ transplant patients, and it is important to ...
Junkichi Kanda, N. Izumo, Megumi Furukawa, Taketoshi Shimakura, N. Yamamoto, Hideaki E Takahashi, T. Asakura, H. Wakabayashi   +7 more
semanticscholar   +1 more source

Structure of Cyclosporine and Its Metabolites: Total Synthesis of Cyclosporine Metabolites Formed by Oxidation at Positions 4 and 9 of Cyclosporine. Preparation of Leucine-4-cyclosporine, (?-Hydroxy)-N-methyl-leucine-9-cyclosporine and Leucine-4-(?-hydroxy)-N-methyl-leucine-9-cyclosporine

CHIMIA, 1992
The syntheses of the cyclosporine metabolites Leu-4-cyclosporine (AM4N), (?-OH)MeLeu-9-cyciosporine (AM9) and Leu-4-(?-OH)MeLeu-cyclosporine (AM4N9) were completed. Aspartic acid was used as starting material to prepare peptides containing (?-OH)
Roland M. Wenger, Kurt Martin, Charles Timbers, Anne Tromelin   +3 more
doaj   +2 more sources

Oral cyclosporine therapy for refractory severe vernal keratoconjunctivitis

Indian Journal of Ophthalmology, 2012
We report the success of oral cyclosporine therapy in a patient with severe vision-threatening vernal keratoconjunctivitis. A child presented with severe allergy which was not controlled with topical steroids, cyclosporine and mast cell stabilizers. Oral
Nikhil S Gokhale, Rohini Samant, Vishnu Sharma   +2 more
doaj   +1 more source

Pharmacokinetic Assessment of Drug‐Drug Interactions of Isavuconazole With the Immunosuppressants Cyclosporine, Mycophenolic Acid, Prednisolone, Sirolimus, and Tacrolimus in Healthy Adults

Clinical pharmacology in drug development, 2016
This report summarizes phase 1 studies that evaluated pharmacokinetic interactions between the novel triazole antifungal agent isavuconazole and the immunosuppressants cyclosporine, mycophenolic acid, prednisolone, sirolimus, and tacrolimus in healthy ...
A. Groll, A. Desai, David Han, Corrie Howieson, Kota Kato, S. Akhtar, D. Kowalski, C. Lademacher, W. Lewis, H. Pearlman, D. Mandarino, T. Yamazaki, R. Townsend   +12 more
semanticscholar   +1 more source

Comparison of the Effect of and Compliance With Cyclosporine 0.1% After Various Pretreatments in Dry Eye Disease

Journal of Ophthalmology
Conclusion: Pretreatment with cyclosporine 0.05% can augment the anti-inflammatory effect of cyclosporine 0.1%. Pretreatment with a steroid or a lower concentration of cyclosporine can increase compliance in patients using a cyclosporine 0.1% eye drop.
Donghyun Jee, Su Yeon Han, Hyun Seung Kim, Eun Chul Kim   +3 more
doaj   +1 more source