Results 21 to 30 of about 15,168 (224)

LPS‐Induced Mitochondrial Damage via SLC41A1‐Mediated Magnesium Ion Efflux Leads to the Pyroptosis of Dental Stem Cells

Advanced Science, EarlyView.
Lipopolysaccharide induces upregulation of the magnesium (Mg2+) efflux transporter solute carrier family 41 member 1 in dental stem cells, leading to a decrease in intracellular Mg2+ concentration and promoting the binding of oligomycin sensitivity‐conferring protein and cyclophilinD.
Yuan Liu, Chenyu Song, Liyuan Zhang, Xue Han, Chaoyuan Li, Yanhong Yan, Ludan Xing, Mengting Si, Bo Yang, Lingyuan Cheng, Akimi Muramatsu, Beizhan Jiang   +11 more
wiley   +1 more source

Crestal approach for repair of oroantral bone defects and subsequent implant placement

Clinical Advances in Periodontics, EarlyView.
Abstract Background Oroantral communication (OAC) can occur after a dental extraction. Occasionally, bony defects may persist despite successful soft tissue closure of the OAC. The absence of bone in these areas poses challenges for dental implant placement.
Min Yang, Miriam Ting, Rodrigo Neiva, Jonathan Korostoff   +3 more
wiley   +1 more source

Health Impacts of Traditional Medicines and Bio-prospecting: A World Scenario Accentuating Bhutan's Perspective [PDF]

, 2008
Life without natural products is unimaginable. It has provided mankind with oxygen, water, fire, food, clothing, shelter and medicine. Its public health impact is considerably high, especially of traditional medicines and nature-based modern drugs.
Wangchuk, Phurpa
core  

Stachybotrys [PDF]

, 2011
61.1 Introduction 61.1.1 Classification, Morphology, and Biology 61.1.2 Clinical Features and Pathogenesis 61.1.2.1 Clinical Features 61.1.2.2 Pathogenesis 61.1.3 Diagnosis 61.2 Methods 61.2.1 Sample Preparation 61.2.1.1 Trichothecene Collection ...
Liu, Dongyou, Paterson, R. R. M.
core   +1 more source

Voclosporin‐induced gingival enlargement: A case report

Clinical Advances in Periodontics, EarlyView.
Abstract Background Drug‐influenced gingival enlargement (DIGE) is a recognized adverse effect of certain medications, particularly immunosuppressants like cyclosporin and tacrolimus. However, there have been no documented cases of DIGE associated with voclosporin, a newer calcineurin inhibitor used primarily to treat lupus nephritis.
Francesca Racca, Jessica M. Greco, Dimitris N. Tatakis   +2 more
wiley   +1 more source

Drug Repurposing for Duchenne Muscular Dystrophy: The Monoamine Oxidase B Inhibitor Safinamide Ameliorates the Pathological Phenotype in mdx Mice and in Myogenic Cultures From DMD Patients [PDF]

, 2018
Oxidative stress and mitochondrial dysfunction play a crucial role in the pathophysiology of muscular dystrophies. We previously reported that the mitochondrial enzyme monoamine oxidase (MAO) is a relevant source of reactive oxygen species (ROS) not only
Acosta, Manuel, Blaauw, Bert, Canton, Marcella, Forestan, Giada, Marabita, Manuela, Mouly, Vincent, Nogara, Leonardo, Salviati, Leonardo, Sorato, Elisa, Vitiello, Libero   +9 more
core   +6 more sources

Predicting OCT2/MATEs‐Mediated Drug Interactions in Healthy Volunteers and Patients with Chronic Kidney Disease: Insights from Extended Clearance Concept, Endogenous Biomarkers, and In Vitro Inhibition Studies (Perspectives from the International Transporter Consortium)

Clinical Pharmacology &Therapeutics, EarlyView.
Organic cation transporter (OCT) 2 and multidrug and toxin extrusion (MATE) transporters play significant roles in the renal secretion of organic cations and drug–drug interactions (DDIs). Recent in vitro studies indicate that the Ki values for OCT2 exhibit substrate dependency and increase in potency with pre‐incubation.
Satoshi Asano, Aleksandra Galetin, Yoshiko Tomita, Kathleen M. Giacomini, Xiaoyan Chu, Xinning Yang, Toshimichi Nakamura, Hiroyuki Kusuhara, Yuichi Sugiyama   +8 more
wiley   +1 more source

Restoration of Taxol Sensitivity of Multidrug-Resistant Cells by the Cyclosporine SDZ PSC 833 and the Cyclopeptolide SDZ 280-446 [PDF]

, 2017
Background: Taxol, a promising agent for the treatment of cancer, has entered phase II clinical trials. Nevertheless, it belongs to the class of compounds that show impaired retention in multidrug-resistant cells expressing P-glycoprotein (Pgp), a drug ...
Jachez, Bénédicte, Loor, Francis, Nordmann, Rene   +2 more
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Adalimumab, etanercept and ustekinumab for treating plaque psoriasis in children and young people: systematic review and economic evaluation [PDF]

, 2017
Background: Psoriasis is a chronic inflammatory disease that predominantly affects the skin. Adalimumab (HUMIRA®, AbbVie, Maidenhead, UK), etanercept (Enbrel®, Pfizer, New York, NY, USA) and ustekinumab (STELARA®, Janssen Biotech, Inc., Titusville, NJ ...
AbbVie, Ali, All Wales Medicines Strategy Group, All Wales Therapeutics and Toxicology Centre, Altmeyer, Amgen Inc, Amgen Inc, Amgen Inc, Amgen Inc, Amornpinyokeit, Asahina, Balzola, Barker, Basko-Plluska, Basra, Benoit, Berth-Jones, Bigby, Bissonnette, Bonafede, Brunasso, Brănişteanu, Burden-Teh, Burden-Teh, Burden-Teh, Burmester, Burmester, Centre for Reviews and Dissemination, Chaudhari, Chen, Chingcuanco, Chiu, Christiansen, Christophers, Cooper, Corbett, da Silva, Dakin, de Jager, De Jager, de Jager, Department of Health, Dias, Dias, Dias, Dias, DiMarco, Dixon, Dolan, Driessen, Eissing, Elder, Elewski, Esposito, European Medicines Agency, European Medicines Agency, European Medicines Agency, European Medicines Agency, European Medicines Agency, European Medicines Agency, European Medicines Agency, European Medicines Agency, European Medicines Agency, EuroQol Research Foundation, Faerber, Fallah Arani, Famenini, Farhi, Feldman, Flytström, Fonia, Garber, Geiger, Gisondi, Gniadecki, Gniadecki, Gordon, Gordon, Gottlieb, Gottlieb, Greater Medicines Management Group, Griffiths, Guenther, Heydendael, Heydendael, Higgins, Higgins, Ho, Holme, Howe, Ibfelt, Ibrahim, Igarashi, Italian Multicenter Study Group on Cyclosporin in Psoriasis, Janagond, Jankovic, Janssen Biotech, Inc, Janssen Research & Development, LLC, Janssen Research & Development, LLC, Janssen Research & Development, LLC, Janssen-Cilag International, Joint Formulary Committee, Khan, Kim, Kim, Kimball, Klufas, Koo, Kragballe, Krueger, Krueger, Kurd, Laburte, Landells, Landells, Landells, Langley, Langley, Langley, Langley, Lara-Corrales, Lebwohl, Lebwohl, Lefebvre, Lefebvre, Leman, Leonardi, Leonardi, Levy, Lewis-Jones, Lu, Lynde, López-Ferrer, Mahé, Meffert, Melis, Menter, Menter, Menter, MIMS, Moher, National Horizon Scanning Centre, National Institute for Health and Care Excellence, National Institute for Health and Care Excellence, National Institute for Health and Care Excellence, National Institute for Health and Care Excellence, National Institute for Health and Care Excellence, National Institute for Health and Care Excellence, National Institute for Health and Care Excellence, National Institute for Health and Care Excellence, National Institute for Health and Care Excellence, National Institute for Health and Care Excellence, National Institute for Health and Care Excellence, National Institute for Health and Care Excellence, NIHR Horizon Scanning Centre, NIHR Horizon Scanning Centre, Norman, Novartis Pharmaceuticals, Novartis Pharmaceuticals, Office for National Statistics, Oostveen, Paller, Paller, Paller, Paller, Paller, Paller, Paller, Paller, Paller, Papp, Papp, Papp, Papp, Papp, Papp, Papp, Papp, Papp, Parisi, Park, Paul, Pereira, Pfizer, Pfizer, Phillipp, Puig, Ranjan, Reich, Reich, Rencz, Revicki, Richardson, Rodgers, Romero-Maté, Royal College of Paediatrics and Child Health, Ruano, Ruzicka, Ryan, Salek, Sanclemente, Saurat, Schabert, Seminara, Seyger, Shah, Siegfried, Siegfried, Signorovitch, Smith, Soliman, Strand, Strohal, Strohal, Sutton, Takashima, Tanew, Tarp, Torii, Tsai, Umezawa, Upton, US Food and Drug Administration, van de Kerkhof, van Reenen, Varni, Varni, Varni, Vencovsky, Vickers, Warren, Warren, Woods, Woolacott, Wu, Wyeth, Yang, Young, Zachariae, Zhu   +239 more
core   +3 more sources

Mitochondrial targets in ischaemic heart disease and heart failure, and their potential for a more efficient clinical translation. A scientific statement of the ESC Working Group on Cellular Biology of the Heart and the ESC Working Group on Myocardial Function

European Journal of Heart Failure, EarlyView.
Improving clinical translation of mitoprotective therapies. 31P MRI, phosphorus‐31 magnetic resonance imaging; hiPSC‐CM, human‐induced pluripotent stem cell‐derived cardiomyocyte; IHD, ischaemic heart disease. Abstract Acute myocardial infarction (MI) remains a major cause of death and disability worldwide.
Melanie Paillard, Mahmoud Abdellatif, Ioanna Andreadou, Christian Bär, Luc Bertrand, Bianca J.J.M. Brundel, Gemma Chiva‐Blanch, Sean M. Davidson, Dana Dawson, Fabio Di Lisa, Paul Evans, Zoltan Giricz, Derek J. Hausenloy, Petra Kleinbongard, Frank Lezoualc'h, Elisa Liehn, Christoph Maack, Ange Maguy, Elizabeth Murphy, Cinzia Perrino, Maurizio Pesce, Peter P. Rainer, Katrin Streckfuss‐Bömeke, Matthias Thielmann, Rong Tian, Carlo G. Tocchetti, Jolanda Van Der Velden, Sophie Van Linthout, Serena Zacchigna, Thomas Krieg   +29 more
wiley   +1 more source