Results 31 to 40 of about 15,168 (224)

Proportion of Osteoporotic Women Remaining at Risk for Fracture Despite Adherence to Oral Bisphosphonates [PDF]

, 2016
Background Adherence to oral bisphosphonates is often low, but even adherent patients may remain at elevated fracture risk. The goal of this study was to estimate the proportion of bisphosphonate-adherent women remaining at high risk of fracture ...
Allen, Katie, de Papp, Anne, Eckert, George, Hui, Siu L., Imel, Erik A., Johnston, C. Conrad, Li, Zhuokai, Liu, Ziyue, Martin, Joel, Modi, Ankita   +9 more
core   +1 more source

Exploring Immediate Photon Effects From 635 nm Light on Mitochondrial Bioenergetics

Journal of Biophotonics, EarlyView.
The investigation of in vitro impacts of 635 nm laser irradiation in mitochondrial bioenergetics demonstrated that red light induces transient and localized effects, highlighting the complexities of cellular and mitochondrial photostimulation mechanisms. ABSTRACT Visible light primarily targets mitochondria at the cellular level, but photon interaction
Natasha F. Mezzacappo, Natalia M. Inada, Edilene S. Siqueira‐Santos, José Dirceu Vollet‐Filho, Roger F. Castilho, Michael L. Denton, Vanderlei S. Bagnato   +6 more
wiley   +1 more source

North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition position paper on the therapeutic drug monitoring in pediatric inflammatory bowel disease

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Inflammatory bowel diseases (IBD) require effective therapies to prevent morbidity and maintain quality of life. The introduction of biologic agents, beginning with monoclonal antibodies targeting tumor necrosis factor (TNF) alpha, has launched a new era of advancements that have markedly improved short‐ and long‐term outcomes of Crohn's ...
Lina M. Felipez, Sabina Ali, Edwin F. de Zoeten, Anne M. Griffiths, Sandra C. Kim, Ashish S. Patel, Joel R. Rosh, Jeremy Adler   +7 more
wiley   +1 more source

Sebaceous hyperplasia: a pilot study to correlate this skin disease with circulating androgen levels [PDF]

, 2011
BACKGROUND: The sebaceous glands are susceptible to the effects of androgens. A benign proliferation of these hormones, i.e. hyperplasia, occurs with age.
Alchorne, Maurício Mota de Avelar, Enokihara, Mauro, Tagliolatto, Sandra   +2 more
core   +2 more sources

Criteria for Commencing and Continuing Subsidised Janus Kinase Inhibitor Therapy in Australian Alopecia Areata Patients—Results From an Australian Expert Consensus Exercise

Australasian Journal of Dermatology, EarlyView.
ABSTRACT Background/Objectives Janus kinase inhibitors (JAKis) have been approved by the Therapeutic Goods Administration for severe alopecia areata (AA) in Australia. However, access is limited as JAKis are not currently subsidised on the Pharmaceutical Benefits Scheme for this indication. This study aimed to establish expert consensus on criteria for
Meryl Thomas, Madeline Hankins, Emadodin Darchini‐Maragheh, Laita Bokhari, Samantha Eisman, Leona Yip, Katherine York, Jane Li, Pooja Sharma, Daranporn Triwongwaranat, Vijaya Chitreddy, Ragini Ghiya, Daniella Kushnir‐Grinbaum, John Frewen, Shin Shen Yong, Deepani Rathnayake, William Cranwell, Dmitri Wall, Vanathy Varathan, Kiarash Khosrotehrani, David Orchard, Anthony Moussa, Meghana Paranjape, Rodney Sinclair   +23 more
wiley   +1 more source

The Host Immune Response to Tissue-Engineered Organs: Current Problems and Future Directions [PDF]

, 2016
As the global health burden of chronic disease increases, end-stage organ failure has become a costly and intractable problem. De novo organ creation is one of the long-term goals of the medical community.
Birchall, MA, De Coppi, P, Fishman, JM, Wiles, K   +3 more
core   +1 more source

Breast and Nipple Dermatoses During Lactation

Australasian Journal of Dermatology, EarlyView.
ABSTRACT Lactation and breastfeeding can present both psychological and physical challenges for breastfeeding mothers. In addition, many nursing mothers will also suffer from breast and nipple dermatoses during this period, compounding these difficulties. Common causes of breast and nipple dermatitis during lactation include eczema, psoriasis, mastitis,
Hamish Moore, Annabel Stevenson
wiley   +1 more source

Cyclosporin A-binding protein (cyclophilin) of Neurospora crassa [PDF]

, 1988
Cyclophilin (cyclosporin A-binding protein) has a dual localization in the mitochondria and in the cytosol of Neurospora crassa. The two forms are encoded by a single gene which is transcribed into mRNAs having different lengths and 5' termini ...
Hartl, Franz-Ulrich, Köhler, Helmut, Neupert, Walter, Nicholson, Donald W., Pfanner, Nikolaus, Tropschug, Maximilian, Wachter, Elmar   +6 more
core  

Inhibition of ROS1 activity with lorlatinib reversibly suppresses fertility in male mice

Andrology, EarlyView.
Abstract Background Inhibition of sperm maturation in the epididymis is a promising post‐testicular strategy for short‐acting male contraceptives. It has been shown that ROS1, a receptor tyrosine kinase expressed in the epididymis, is essential for epididymal differentiation, sperm maturation, and male fertility in mice.
Yuki Oyama, Kentaro Shimada, Haruhiko Miyata, Rie Iida‐Norita, Chihiro Emori, Maki Kamoshita, Seiya Oura, Ryohei Katayama, Martin M. Matzuk, Masahito Ikawa   +9 more
wiley   +1 more source

Anti-Trypanosoma cruzi effects of cyclosporin A derivatives: possible role of a P-glycoprotein and parasite cyclophilins [PDF]

, 2017
Cyclophilins are target molecules for cyclosporin A (CsA), an immunosuppressive antimicrobial drug. We have previously reported the in vitro anti-Trypanosoma cruzi activity of H-7-94 and F-7-62 non-immunosuppressive CsA analogues.
BÚA, J., DUBIN, M., FICHERA, L.E., FUCHS, A.G., MORETTI, G., POTENZA, M., RUIZ, A.M., SCABONE, C.M., WENGER, R.O.   +8 more
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