Results 61 to 70 of about 3,841 (191)

Potential Diagnosis and Prognosis Value of Plasma MicroRNA-19a in Esophageal Cancer [PDF]

, 2015
背景：食管癌是发生于食管上皮组织的恶性肿瘤，具有高死亡率、高复发率和高转移率的特点。然而目前针对食管癌敏感的肿瘤标志物不多，且诊断效率较低，远远不能满足临床需求。MicroRNA是一类非编码RNA，可以稳定存在于人体血浆中并且易于检测。据报道，microRNA在诸多疾病状态下会出现表达异常，如食管癌、结直肠癌、肝癌等，这一发现极大地增加了血浆microRNA作为食管癌标志物的可能。在前期实验中，我们观察到microRNA-19a（miR-19a）在食管癌血浆标本中高表达，本文将重点探讨miR ...
白永颖
core  

CYFRA21-1 levels could be a biomarker for bladder cancer: a meta-analysis

Genetics and Molecular Research, 2015
The proteolytic region of cytokeratin-19, referred to as CYFRA21-1, is a soluble molecule present in the serum and other body fluids, and is considered a tumor marker in several neoplastic diseases. To examine whether urinary or serum samples containing CYFRA21-1 can be used as biomarkers for bladder cancer, we conducted a comprehensive meta-analysis ...
L I, Kuang, W J, Song, H M, Qing, S, Yan, F L, Song   +4 more
openaire   +2 more sources

Integrating Clinical Features, Laboratory Biomarkers and Computed Tomography for the Discrimination of Non‐Small Cell Lung Cancer and Benign Pulmonary Diseases: A Clinical Prediction Model

Journal of Clinical Laboratory Analysis, Volume 40, Issue 4, February 2026.
This study developed and validated a clinical prediction model to differentiate non‐small cell lung cancer (NSCLC) from benign pulmonary diseases using clinical features, laboratory biomarkers, and CT features. The model achieved an AUC‐ROC of 0.95 in the training set and 0.82 in the validation set, demonstrating reliable diagnostic performance and ...
Jie Zhang, Shui Liu, Mingjian Bai, Fucun Ma, Guowei Liang, Bing Wang   +5 more
wiley   +1 more source

The Diagnostic and Prognostic Value of the Combination of Tumor M2-Pyruvate Kinase, Carcinoembryonic Antigen, and Cytokeratin 19 Fragment in Non-Small Cell Lung Cancer

Technology in Cancer Research & Treatment
Objective: Finding biomarkers related to non-small cell lung cancer (NSCLC) is helpful for the diagnosis and precise treatment of lung cancer. The relationship between serum tumor M2-pyruvate kinase (TuM2-PK), carcinoembryonic antigen (CEA), and ...
Li Li MD, Yihan Xu MS, Yuchao Wang PhD, Qian Zhang MD, Yan Wang MD, Chunhua Xu MD   +5 more
doaj   +1 more source

腹腔镜结直肠癌根治术患者血清CYFRA21-1、CA724水平变化与复发转移的关系

Zhongguo shiyan zhenduanxue, 2021
目的探讨腹腔镜结直肠癌根治术患者血清细胞角蛋白19片段抗原(CYFRA21-1)、糖类抗原724(CA724)水平变化与复发转移的关系。方法选取2017年1月至2019年1月重庆市巴南区人民医院腹腔镜结直肠癌根治术患者120例,同期选取体检健康人员120例,所有人员均采用放射免疫法检测血清CYFRA21-1、CA724水平,分析血清CYFRA21-1、CA724水平变化与结直肠癌根治术后复发转移的关系。结果结直肠癌根治术患者血清CYFRA21-1、CA724水平明显高于健康人员 ...
汤红, 雷秀兵, 柴秀丽
doaj  

Clean Colorectum at Diagnostic Colonoscopy:Subsequent Detection of Extracolonic Malignancies by Plasma Protein Biomarkers? [PDF]

, 2018
Introduction: Most of the subjects undergoing diagnostic colonoscopy do not have neoplastic bowel lesions. Potentially, some of the symptoms may therefore be caused by extracolonic malignancy, and subjects with persisting symptoms may need subsequent ...
Christensen, Ib J, Davis, Gerard, Gawel, Susan, Heijboer, Anne Meike, Hillig, Thore, Jørgensen, Lars N, Klærke, Michael, Laurberg, Søren, Madsen, Mogens R, Martens, Frans, Nielsen, Hans J, Nielsen, Knud T, Vilandt, Jesper, Wilhelmsen, Michael, Yang, Xiaoping   +14 more
core   +1 more source

Serum cyfra21-1 as a biomarker in patients with nonsmall cell lung cancer

Journal of Cancer Research and Therapeutics, 2014
The purpose of this retrospective study was to evaluate the clinical value of serum cytokeratin-19-fragment (cyfra21-1) as a biomarker in nonsmall cell lung cancer (NSCLC).Sixty-six patients with NSCLC and 48 cases with benign lung disease were retrospectively analyzed in the department of thoracic surgery in our hospital.
Hongjie, Zhao, Xuejun, Shi, Jinbo, Liu, Zhengang, Chen, Guangshun, Wang   +4 more
openaire   +2 more sources

Non‐Destructively Quantifying the Whole‐Course Growth and Drug‐Response of PDOs by an Automatic Microfluidic System Utilizing Chemiluminescence Detection

Advanced Science, Volume 13, Issue 2, 9 January 2026.
The detection of secreted biomarkers enables molecular variations monitoring of organoid status. In this study, the non‐destructive quantification for the whole‐course growth and drug‐response of PDOs is first realized using a multifunctional microfluidic chip‐based system(ASMO) that integrates culturing, drug incubation, and biomarker detection ...
Yu Zhang, Daoyun Wang, Zhicheng Huang, Nan Zhang, Zhina Wang, Xin Wu, Anlan Zhang, Runzhi Yang, Tong Li, Zhibo Zheng, Yuxiao Lin, Naixin Liang, Zewen Wei   +12 more
wiley   +1 more source

Significance of Serum Tumor Markers in Esophageal and Gastric Cancers: A Systematic Literature Review

Annals of Gastroenterological Surgery, Volume 10, Issue 1, Page 54-66, January 2026.
The utility of serum tumor markers in esophageal squamous cell carcinoma and gastric cancer were evaluated by systematic review and meta‐analysis. In addition, the position of each marker, strategies for improving their accuracy in the future, and new markers are also described.
Yasunori Matsumoto, Takeshi Toyozumi, Hideaki Shimada   +2 more
wiley   +1 more source

Serum CYFRA21–1 and SCC-Ag levels in women during pregnancy and their diagnostic value for cervical cancer

Cancer Treatment and Research Communications
Objectives: The incidence of cervical cancer increases every year during pregnancy. Cervical cytology in pregnant women has a unique morphology and liquid-based cytology methods are prone to cause false positives. The aim of this study was to investigate
Qianlan Zhang, Zhiheng Wang, Huijing Tang, Bin Zhang, Chaoyan Yue, Jin Gao, Chunmei Ying   +6 more
doaj   +1 more source