Results 111 to 120 of about 9,202 (195)

Targeting mitochondrial 18 kDa translocator protein (TSPO) regulates macrophage cholesterol efflux and lipid phenotype [PDF]

, 2014
The aim of the present study was to establish mitochondrial cholesterol trafficking 18 kDa translocator protein (TSPO) as a potential therapeutic target, capable of increasing macrophage cholesterol efflux to (apo)lipoprotein acceptors.
Anne-Marie Allen, Annette Graham, Batarseh, Bird, Borthwick, Borthwick, Brown, Dmitrova-Shumkovska, Engel, Falchi, Farke, Feramisco, Fernandez-Hernando, Gallus, Gerrity, Gut, Hebbachi, Janice M. W. Taylor, Kannel, Khan, Lecanu, Madamanchi, Mercer, Ning, Ning, Ogata, Oram, Pandak, Puddu, Pyper, Rae, Ren, Rigamonti, Rone, Rosenson-Schloss, Rupprecht, Schnoor, Schultz, Taylor, Vanhee, Venkateswaran, Wang, Xu, Yelieev, Zeng, Zeng, Zoltan   +46 more
core   +1 more source

Effect of increasing the expression of cholesterol transporters (StAR, MLN64, and SCP-2) on bile acid synthesis

Journal of Lipid Research, 2004
There are two major pathways of bile acid synthesis: the “neutral” pathway, initiated by highly regulated microsomal cholesterol 7α-hydroxylase (CYP7A1), and an “alternative” pathway, initiated by mitochondrial sterol 27-hydroxylase (CYP27A1).
Shunlin Ren, Phillip Hylemon, Dalila Marques, Elizabeth Hall, Kaye Redford, Gregorio Gil, William M. Pandak   +6 more
doaj   +1 more source

ApoA-I mimetic administration, but not increased apoA-I-containing HDL, inhibits tumour growth in a mouse model of inherited breast cancer [PDF]

, 2017
Low levels of high-density lipoprotein cholesterol (HDLc) have been associated with breast cancer risk, but several epidemiologic studies have reported contradictory results with regard to the relationship between apolipoprotein (apo) A-I and breast ...
Blanco-Vaca, Francisco, Cedó, Lídia, Escolà-Gil, Joan Carles, García-León, Annabel, Lerma, Enrique, López-Vilaró, Laura, Martínez-Cignoni, Melanie Raquel, Santos, David   +7 more
core   +1 more source

Abstract 199: Host CYP27A1 expression is essential for ovarian cancer progression

Cancer Research, 2018
Abstract Ovarian cancer continues to have a high mortality and recurrence rate. Hence, there is an urgent need to develop new therapeutic or lifestyle strategies. In this regard, epidemiological studies have implicated elevated cholesterol as a negative prognostic factor.
Sisi He, Amy E. Baek, Liqian Ma, Joanna Burdette, Erik R. Nelson   +4 more
openaire   +1 more source

Maternal VDR variants rather than 25-hydroxyvitamin D concentration during early pregnancy are associated with type 1 diabetes in the offspring [PDF]

, 2016
This study was supported by the Finnish Academy (grant 127219), the European Foundation for the Study of Diabetes, the Novo Nordisk Foundation, the Diabetes Research Foundation, the EVO funding of the South Ostrobothnia Central Hospital from the ...
AG Uitterlinden, AW Norman, B Frederiksen, B-W Ogunkolade, BN Frederiksen, Christel Lamberg-Allardt, Christopher Mathews, D Saccone, E Hyppönen, E Ramos-Lopez, E Ramos-Lopez, EL Barry, Graham A. Hitman, Heljä-Marja Surcel, HK Brekke, HT Siljander, IM Sørensen, J Ahn, J Ahn, J Esparza-Gordillo, J Raab, Jaakko Tuomilehto, JD Cooper, JJ McGrath, JR Pilsner, L Marjamäki, LC Stene, LC Stene, Leena Kinnunen, M Shahbazi, M Simpson, Maija E. Miettinen, ME Miettinen, Melissa C. Smart, MF Holick, NJ Knaap van der, R Bailey, S Nejentsev, SJ James, SM Orton, The EURODIAB Substudy 2 Study Group, TJ Wang, Valma Harjutsalo, X Guillot, Y Benjamini   +44 more
core   +1 more source

Selective inhibition of CYP27A1 and of chenodeoxycholic acid synthesis in cholestatic hamster liver

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2002
The aim of this study was to explore the regulation of serum cholic acid (CA)/chenodeoxycholic acid (CDCA) ratio in cholestatic hamster induced by ligation of the common bile duct for 48 h. The serum concentration of total bile acids and CA/CDCA ratio were significantly elevated, and the serum proportion of unconjugated bile acids to total bile acids ...
Matsuzaki, Yasushi, Bouscarel, Bernard, Ikegami, Tadashi, Honda, Akira, Doy, Mikio, Ceryak, Susan, Fukushima, Sugano, Yoshida, Shigemasa, Shoda, Junichi, Tanaka, Naomi   +9 more
openaire   +2 more sources

A novel mutation in the sterol 27-hydroxylase gene of a woman with autosomal recessive cerebrotendinous xanthomatosis

Orphanet Journal of Rare Diseases, 2010
Article abstract Mutations of the gene encoding the mitochondrial enzyme sterol 27-hydroxylase (CYP27A1 gene) cause defects in the cholesterol pathway to bile acids that lead to the storage of cholestanol and cholesterol in tendons, lenses and the ...
Garuti Rita, Vogel Hans-Peter, Lingesleben Alexandra, Schneider Hauke, Calandra Sebastiano   +4 more
doaj   +1 more source

Late-onset Cerebrotendinous Xanthomatosis with a Novel Mutation in the CYP27A1 Gene.

Internal medicine (Tokyo, Japan), 2018
Cerebrotendinous xanthomatosis (CTX) is a rare, autosomal recessive, inborn disruption in bile acid synthesis characterized by severe systemic xanthomas, cataracts and neurological injuries occurring before adolescence without elevation of the serum cholesterol or triglyceride levels.
Sasamura, Akari, Akazawa, Satoru, Haraguchi, Ai, Horie, Ichiro, Ando, Takao, Abiru, Norio, Takei, Hajime, Nittono, Hiroshi, Une, Mizuho, Kurosawa, Takao, Murai, Tsuyoshi, Naruse, Hiromu, Nakayama, Tomohiro, Kotani, Kazuhiko, Remaley, Alan T., Kawakami, Atsushi   +15 more
openaire   +2 more sources

Expression of key enzymes in bile acid biosynthesis during development: CYP7B1-mediated activities show tissue-specific differences

Journal of Lipid Research, 2002
The developmental variation of cytochrome P450 (CYP)7A1, CYP7B1, CYP27A1, and 3β-hydroxy-Δ5-C27-steroid dehydrogenase, key enzymes in bile acid biosynthesis, were investigated in pigs of different ages.
Maria Norlin
doaj   +1 more source

Vitamin D and calcium metabolism in horses in New Zealand : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Veterinary Science at Institute of Veterinary, Animal and Biomedical Sciences (IVABS), Massey University, Manawatū, New Zealand [PDF]

, 2016
The physiology of vitamin D in horses has not been studied in great depth. Few studies on vitamin D metabolites (25OHD2, 25OHD3, and 1,25(OH)2D) and their relationship to other serum analytes exist. In addition, some studies suggest that equine vitamin D
Azarpeykan, Sara
core