Results 91 to 100 of about 10,726 (197)

Are cytochrome P450 CYP2C8 and CYP2C9 polymorphisms associated with ibuprofen response in very preterm infants?

PLoS ONE, 2010
BackgroundPatent ductus arteriosus (PDA) in extremely preterm infants remains a challenging condition with conflicting treatment strategies. Ibuprofen is currently used to treat PDA with ductal closure failure rate up to 40%.
Xavier Durrmeyer, Shushanik Hovhannisyan, Yves Médard, Evelyne Jacqz-Aigrain, Fabrice Decobert, Jérome Barre, Corinne Alberti, Yannick Aujard, Claude Danan, Olivier Baud   +9 more
doaj   +1 more source

Relevance of non-synonymous CYP2C8 polymorphisms to 13-cis retinoic acid and paclitaxel hydroxylation

CYP2C8 has a major role in the metabolism of the anticancer agents 13-cis retinoic acid (13cisRA) and paclitaxel. There is evidence that polymorphisms in the CYP2C8 gene contribute to observed interindividual differences in paclitaxel metabolism. However,
Veal GJ, Rowbotham SE, Boddy AV, Daly AK, Redfern CPF   +4 more
core   +5 more sources

In Silico Dock of TKIs with CYP3A4 and CYP2C8 and Pharmacophore Generation [PDF]

BIO Web of Conferences
Tyrosine kinase inhibitors (TKIs) serve as targeted anticancer drugs that inhibit the abnormal activity of tyrosine kinase (TK) in cancer treatment. However, when used with other medications, they often result in side effects, such as renal impairment ...
Ma Zhenya
doaj   +1 more source

Substrate / inhibitor influence on CYP2C8 with implications for related isoforms

, 2005
Compounds were hydroxylated in incubations containing CYP1A2, CYP2B6, or CYP2C19 SupersomesTM, with a large turnover number observed for CYP2B6-dependent flavonone metabolism (>20% loss of parent).
Devereux, R Mark
core  

Gemfibrotsiilin aiheuttama CYP2C8-entsyymi-inaktivaatio ihmisissä : aika- ja annossuhteiden selvittäminen [PDF]

, 2011
Drug-drug interactions may cause serious, even fatal clinical consequences. Therefore, it is important to examine the interaction potential of new chemical entities early in drug development.
Honkalammi, Johanna
core  

CYP2C8 polymorphisms in Caucasians and their relationship with paclitaxel 6α-hydroxylase activity in human liver microsomes

Published cDNA sequences suggest the existence of non-synonymous single nucleotide polymorphisms in the cytochrome P450 CYP2C8. To determine whether these polymorphisms could be confirmed in a Caucasian population and to investigate whether additional ...
Gilissen R, Williams FM, Bahadur N, Houdt JV, Mutch E, Bohets H, Crespi CL, Hendrickx J, Mannens G, Dunn SA, Steimel-Crespi D, Daly AK, Armstrong M, Leathart JBS   +13 more
core   +5 more sources

Malaria : efficacy of amodiaquine-sulfadoxine-pyrimethamine, nutritional status and alellic variaton of CYP2C8 gen. [PDF]

, 2012
Problema: La respuesta terapéutica antimalárica depende de múltiples determinantes asociados con el plasmodio (especie, mutaciones, cantidad, etc.) y al hospedero (nutrición, genes, metabolismo, etc.), pero los últimos son poco conocidos.
Carmona Fonseca, Jaime, Guzmán Pérez, Valentina, Maestre Buitrago, Amanda   +2 more
core  

Improving the accuracy of prediction models for small datasets of Cytochrome P450 inhibition with deep learning

Journal of Cheminformatics
The cytochrome P450 (CYP) superfamily metabolises a wide range of compounds; however, drug-induced CYP inhibition can lead to adverse interactions. Identifying potential CYP inhibitors is crucial for safe drug administration.
Elpri Eka Permadi, Reiko Watanabe, Kenji Mizuguchi   +2 more
doaj   +1 more source

Efficacy of piroxicam for postoperative pain after lower third molar surgery associated with CYP2C8*3 and CYP2C9

Journal of Pain Research, 2017
Adriana Maria Calvo, Paulo Zupelari-Gonçalves, Thiago José Dionísio, Daniel Thomas Brozoski, Flávio Augusto Faria, Carlos Ferreira Santos Department of Biological Sciences, Bauru School of Dentistry ...
Calvo AM, Zupelari-Gonçalves P, Dionísio TJ, Brozoski DT, Faria FA, Santos CF   +5 more
doaj  

Role of CYP2C8 in the metabolism of montelukast and imatinib : Studies in vitro, in silico and in humans [PDF]

, 2014
The drug-metabolising enzyme cytochrome P450 (CYP) 2C8 is involved in the elimination of several important drugs. The asthma drug montelukast inhibits CYP2C8 potently in vitro, but does not affect the pharmacokinetics of CYP2C8 substrates in vivo.
Filppula, Anne
core