Results 81 to 90 of about 10,726 (197)
Análisis genético y funcional de polimorfismos de CYP2C8 en muestras de población colombiana: implicaciones en la respuesta a paclitaxel en cáncer de pulmón [PDF]
, 2014 El paclitaxel (Taxol®) es un potente inhibidor de la replicación de células eucariotas, su actividad farmacológica está determinada por su habilidad para unirse a los microtúbulos, detener el ciclo celular e inducir apoptosis.
Morantes Medina, Sandra Johanna
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Pediatric Blood &Cancer, Volume 73, Issue 9, September 2026.ABSTRACT Introduction The use of herbal medical preparation (HMP) is rising among pediatric oncology patients, often to manage treatment‐related symptoms. Their effectiveness remains uncertain, and the risk of herb–drug interactions is underestimated.
Orianne Mahot +6 more
wiley +1 more source
Simultaneous detection of CYP2C8*2, CYP2C8*3, CYP2C8*4 and CYP2C8*5 alleles by a nested PCR method
, 2009 Cytochrome P450 (CYP) 2C8 plays a signi?cant role in metabolizing many clinically important drugs such as paclitaxel, amiodarone and amodiaquine. A simultaneous detection of CYP2C8*2, CYP2C8*3, CYP2C8*4 and CYP2C8*5alleles by a PCR method will be ...
Tuan Norhafizah binti Tuan Zakaria
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Prevalence of the Genetic Mutation CYP2C8*5 in Selected Ethnic Groups in Southern Ghana
, 2016 Aim: The study determined prevalence of clinically relevant CYP2C8*5 polymorphism in 80 unrelated individuals, from selected ethnic groups in Southern Ghana.
Christopher Larbie +2 more
core +1 more source
British Journal of Clinical Pharmacology, Volume 92, Issue 9, Page 3115-3123, September 2026.Abstract Aim Sirolimus is currently used off‐label for paediatric patients with vascular anomalies. However, the optimal dosage regimen for paediatric patients remains controversial. This study aimed to determine the optimal dosing regimen of sirolimus in these patients using a population pharmacokinetic (PK) model.
Seongmee Jeong +13 more
wiley +1 more source
The Roles of EETs in Neurological Disorders
CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.Epoxyeicosatrienoic acids (EETs), derived from arachidonic acid (ARA) via cytochrome P450 (CYP450) enzymes, are produced in nearly all human tissues and exert a wide range of beneficial effects. This review summarizes the roles and potential mechanisms of EETs in neurological disorders, with a focus on cerebrovascular diseases, epilepsy, Parkinson's ...
Rong Tang +6 more
wiley +1 more source
, 2009 Inhibitory Effects of Dibenzocyclooctadiene Lingans from Fructus Schisandrae on CYP2C8-Mediated Paclitaxel Metabolism in Human Liver Microsomes Yan-Yan Zhang, Ling Yang Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical ...
张延延, 杨凌
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Pharmacogenomics and Personalized Medicine, 2020 Lidia Habtemikael,1 Mulugeta Russom,2 Iyassu Bahta,2 Selam Mihreteab,3 Araia Berhane,4 Andreas Mårtensson,1 Jose Pedro Gil1,5,6 1Department of Women’s and Children’s Health, International Maternal and Child Health (IMCH), Uppsala ...
Habtemikael L +6 more
doaj
Clinical Pharmacology &Therapeutics, Volume 120, Issue 3, Page 614-638, September 2026.Antibody–drug conjugates (ADCs) combine the specificity of an antibody with the potency of a cytotoxic drug. Thirteen ADCs, utilizing seven unique cytotoxic payloads and targeting 11 distinct antigens, are currently approved by the US Food and Drug Administration as of June 2025, representing a rapidly growing and highly promising class of anticancer ...
Sijie Lu +6 more
wiley +1 more source
Human CYP2C8: structure, substrate specificity, inhibitor selectivity, inducers and polymorphisms
, 2009 Human CYP2C8 is a key member of the CYP2C family and metabolizes more than 60 clinical drugs. A number of active site residues in CYP2C8 have been identified based on homology modeling and site-directed mutagenesis studies.
Xinsheng Lai (307879) +5 more
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